EFNA4 Effecting On EphA2 Regulates Cell Adhesion And Metastasis In Breast Cancer

实验背景：肿瘤细胞对临近组织和器官的侵袭与远端转移，一直是肿瘤研究的热点。酪氨酸受体蛋白及其配体家族Ephs和Ephrins之间的作用被证实能够调控多种肿瘤细胞的形态，细胞骨架，进而影响细胞的迁移与转移。前期通过荧光定量RT-PCR，我们发现相对于正常组织来源的细胞系，EFNA4在乳腺癌和肝癌细胞系中表达较低。同时在建立的高低侵袭ZR-75-30乳腺癌细胞系中，EFNA4具有表达差异，而EFNA4在肿瘤中的作用鲜有报道。 实验方法与结果：在体外实验中，通过在乳腺癌细胞系中过量表达或通过shRNA敲低EFNA4，发现EFNA4能够抑制细胞的粘附、迁移与侵袭，对细胞增殖没有影响；在体内实验中...Backgroud: Cancer cells have abilities to invade neighboring tissues and metastasize distantly, which is the critical point for malignant tumors progression that threatens life and therefore the hotspot focus of oncology field. The effect of the lagerst family of RTKs: Ephs and the ligands Ephrins have been proved to regulated cytoskeleton, migration and metastasis in a variety of tumor cells. In ...学位：理学博士院系专业：生命科学学院_细胞生物学学号：2162011015396

Response of ColoredDissolved Organic Matter to the Typhoon and ENSO eventsin theTaiwanStrait

在全球变化的大背景下，台风暴雨、厄尔尼诺-南方涛动（ElNino-SouthernOscillation，ENSO）等气候异常事件频发，对边缘海溶解有机物（DOM）的生物地球化学循环产生重要影响，但目前有关边缘海DOM的研究大多侧重于常态天气条件，缺乏极端事件对边缘海DOM源、汇格局的影响及其机制的深入研究。台湾海峡地处西太平洋亚热带海域，台风暴雨事件频发，水团运动、生物生产力与ENSO事件也有明确的关联，因此是研究上述科学问题的理想场所。本论文以九龙江口-台湾海峡交界区和台湾海峡南部海域为研究区域，以DOM的吸收光谱和荧光光谱为分析表征手段，分别探讨了九龙江口-台湾海峡交界区有色溶解有机物（...Unusual or extreme climate events like typhoon, El Nino Southern Oscillation (ENSO) events happen frequentlyin the context of global change. Such events undoubtedly have important impacts on the biogeochemical cycle of dissolved organic matter (DOM) in the marginal seas. However,most studies in this field focused on the normal climate conditions, leaving a great blank onhow the extreme events will...学位：理学硕士院系专业：海洋与地球学院_海洋化学学号：2232014115131

Cloning and Functional Study on a new secrete isoform of EphrinA4(EA4D)

Eph受体是酪氨酸激酶受体家族中最大的一组，Eph及其配体ephrin构成一个非常庞大的信号转导分子系统，调节包括细胞与细胞间相互作用，细胞迁移等多种细胞活动。这个家族已经鉴定主要功能作用，是其在神经系统发育过程中在脑的布线（brainwiring）和神经轴突的生长导向(axonalguidance)方面的作用。因此，它们也是神经导向分子（Neuralguidancemolecules）的一个重要家族。现有研究表明，神经导向分子也在生血管新生和肿瘤发展过程中发挥重要的作用。虽然Eph受体/ephrin配体家族的一些成员被报道与某些肿瘤的生长和存活有关，其高调的表达通常与血管新生和肿瘤血管相关；...The Eph receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. Ephs and their ligands, ephrins, constitute a very large molecular system of signal transduction, which regulates a variety of biological activities, including cell- cell interaction and cell migration. The primarily function identified for this family is its role in brain wiring and axonal guidance for th...学位：理学硕士院系专业：生命科学学院生物学系_生物化学与分子生物学学号：2162007115197

On Exploiting Qualifications of Industrial Tourism and its Developing Venture

对工业旅游的开发条件进行全面、深入的分析是保证工业旅游成功开发的前提和基础,同时,工业旅游开发的成功还离不开对项目风险的认知与评估。从主体条件、客体条件、媒介条件三个方面对工业旅游的开发条件作了较全面的探讨,进而分析了在当前市场条件下,因工业旅游自身局限性可能产生的开发风险。To analyze industrial tourism,exploiting qualifications comprehensively and profoundly is the foundation of successful industrial tourism.At the same time, the successful development is also strongly connected with the acknowledgement and evaluation of the item's venture. This paper makes a comprehensive study of exploiting qualifications from three aspects,including subject, object and medium qualification, and points out the industrial tourism developing venture caused by its limitations under the present market environment

The Type of Enterprise’s Action toward Government and the Strategic Choice of Tourism Enterprise

企业作为组织，不仅在市场中生存，更是在政府所规范的制度环境中生存。旅游业关联性强、独立性弱的特点决定了，旅游企业必须依赖与政府的协调、与市场的共生，才能获得更好的外部发展环境。较之制造业，公共服务供给对旅游企业的影响不仅立竿见影，而且全面、深刻、长远。 中国转型期的政治经济体制决定了，政府不仅通过政策和法规影响企业，还在微观层面干预企业经营。对此，企业是如何应对的？是无条件迎合，还是策略性应对，抑或是在困境中寻求突破？嵌入该制度框架中的旅游企业又该如何作为？本文试图从理论层面回答上述问题。根据中西方企业所处体制环境的差异，本文将企业的政府行动区分为建立政治关联和追求公共服务两类。在界定并比较...Enterprises as organization, not only survive in market, but also survive in the institutional context disciplined by government. The characteristics of strongly connecting and weak independence in tourism industry contribute to the tourism enterprise’s survival logic, that it have to depend on coordinating with government and coexist with market. Without that, tourism enterprises could not get be...学位：管理学博士院系专业：管理学院旅游系_旅游管理学号：B20043900

Investigation into the Reaction Mechanism of Molecular Cluster Batteries by XAFS, NMR, and Magnetic Analysis

名古屋大学Nagoya University博士(理学)名古屋大学博士学位論文 学位の種類:博士(理学) (課程) 学位授与年月日:平成23年9月27日 副論文・参考論文はPDFに含まれていません。doctoral thesi

The Study on Prophase Evaluation of Zhejiang Telecom Investment Projects

电信行业的投资项目往往具有投资金额大、滚动性投放、回收期长的特点，随着电信行业完成重组，行业内的竞争日益激烈，电信项目的投资风险越来越大，一旦出现投资失误，将造成巨大的损失。 本文通过分析浙江电信以往投资项目前期效益评估体系存在的问题，特别是在收入再分配和成本归集方面还没有明确定义的问题，通过对项目收入和运营成本测算方法的研究，以及对收入再分配比例的研究，总结出了一套合理、可操作性较强的评估方法，能提高电信项目投资前期效益评估的科学性和准确性，以指导投资决策。 本文有如下三个主要贡献点： 1、收入和成本测算更加精确合理。针对不同的电信投资项目，选择采用用户数与ARPU值乘积、业务量与产品...Investment projects in the telecommunications industry tend to have a large amount of investment fund which arranges a rolling investment, and has a long payback period. With the completion of restructuring of the telecommunications industry, and the increasing competition within the industry, the telecommunications projects investment risk is increasing. Thus once appearing of the investment mist...学位：工商管理硕士院系专业：管理学院高级经理教育中心（EMBA项目）_高级管理人员工商管理硕士(EMBA)学号：X200615607

一种新型边界元奇异积分计算方法

本文提出一种有效的边界单元法计算技术,用于复合材料的各向异性板.利用正交各向异性材料在静水压力下的解析解计算奇异积分。并结合一种专门的数值积分技术。使本文的方法有效地提高了边界单元法求解复合材料各向异性板的计算精度

Analysis of the new translation of Kubo Tenzui

This paper focuses on the Romance of the Three Kingdoms and the Outlaws of the marsh translated by Kubo Tenzui. The Romance of the Three Kingdoms comprises the main part, and the Outlaws of the marsh supplements it. Compared with the translations of Edo era, it focuses on analyzing its translation features and inheritance. The first chapter briefly describes the history of their acceptance in Japan. It clarifies that Kubo\u27s translation is the first new translation since Meiji period (1868-1912). The second chapter describes kuobao\u27s life and details his translation works. Chapter three and chapter four respectively analyze the translation features of Kubo\u27s version. The main feature is to be as faithful to the original as possible. Finally, the fifth chapter comprehensively analyzes the reasons for its rapid disappearance in the times from the internal and external aspects