Research Progress of Polysaccharides of Portulaca oleracea

本文就近年来国内外有关马齿苋多糖的提取、化学结构、含量测定及药理作用等方面的研究现状进行了概述,并指出马齿苋多糖是一种极具开发潜力和开发价值的天然功能食品,在预防多种疾病的发生及延缓并发症的发展方面有着广阔的应用前景。This paper briefly introduced the extraction, constitution, determination and pharmacology of the polysaccharides of Portulace oleracea L. in the last decade. The polysaccharides of Portulace oleracea L. is a natural functional food with high development potentials and values and will be widely used to prevent various diseases.江西省教育厅科学技术研究项目(赣教技字[2007]285号

Screening of α-glucosidase Inhibitors in Active Constituents from Portulaca oleracea L.

[目的]观察马齿苋活性成分对兔小肠黏膜α-葡萄糖苷酶活性的影响,筛选α-葡萄糖苷酶抑制剂。[方法]提取分离马齿苋活性成分,在体外建立微量酶反应体系,PnPg作为底物,以阿卡波糖为参照,检测马齿苋活性成分对α-葡萄糖苷酶活性的影响。[结果]马齿苋总提取液、粗多糖和总生物碱对α-葡萄糖苷酶具有明显抑制作用,抑制效果接近于阿卡波糖,不饱和脂肪酸和总黄酮无抑制作用。[结论]马齿苋防治糖尿病的主要成分是生物碱和多糖,可能具有阿卡波糖样的降糖机制。[Objective] The research aimed to observe the effects of active constituents from Portulaca oleracea L.on α-glucosidase activity in intestine mucous to screen α-glucosidase inhibitors.[Method] The active constituents were extracted from Portulaca oleracea L..The trace enzyme reaction system was constructed in vitro.Taking the pNPG as substrate,and acarbose as control,the effects of the active constituents from Portulaca oleracea L.on α-glucosidase activity.[Result] Total extraction,alkaloids and polysaccharides from Portulaca oleracea L.could obviously inhibit α-glucosidase activity,but polyunsaturated fatty acid and flavonoids had no inhibition.[Conclusion] The main active constituents are alkaloids and polysaccharides from Portulaca oleracea L.for preventing diabetes,and the hypoglycemic mechanism is similar to acarbose.江西省教育厅科技项目(赣教技字〔2007〕285号);江西科技师范学院人才创新基金项目(2005