The research of multi-class problem based gene expression profile data

针对基因表达谱微阵列的数据多分类问题,给出一种在多病类情况下的基于信噪比和相关性的特征基因选择方法.该方法一次性考虑基因区分所有病类的能力,尽量避免基因的冗余性;其次利用支持向量机,构建了基因表达谱微阵列数据的多分类器;最后通过实验表明了本方法的有效性.Aiming at the multi-class problem of gene expression profile data,this paper proposes a gene selection method based on S2N and correlation for multiple diseases.This method takes the classification abilities of genes to separate all the diseases into consideration at a time and tries to avoid redundancy in selected genes.Secondly,we construct multi-classifier of gene expression profile data using SVM.Finally,we do experiment by this method,the result of which shows great effectiveness of the method.国家自然科学基金资助项目(60704042

The Method of Fax Receiver's Name Recognition Based on SVM

在字符特征提取基础上,文章提出了应用支持向量机对传真收件人进行识别的方案,解决了传真收件人格式、表示方法多样性而导致的自动分发困难的问题。文中对四种常用的核函数分别进行了实验,选取了对传真收件人具有较高识别率的核函数,它有利于实现传真文件的自动分发。Based on characters feature extraction,the scheme of fax receiver's recognition is advanced in this paper by the use of SVM,which solves some problems such as the format of fax receiver and the difficulty of intelligent distribution caused by the diversity of expressing methods.Four common kernel functions are experimented respectively in this paper,and the kernel function that has better recognizing accuracy to fax receiver is selected,which can make for the realization of the intelligent distribution of fax

A forecast of bulk-holding stock based on random forest

首先通过对基金重仓股的财务指标和市场指标的分析,建立一套科学合理的基金重仓股指标体系;其次利用随机森林建立基金重仓股的预测模型;最后通过实验验证了方法的有效性和优越性.本研究将为投资者提供一个投资决策的优良工具.Firstly we construct a system of scientific stock index by means of analysis of financing index and market index.Secondly we construct forecast model based on random forest.In the end,numerical results show that the method used is effective and advantageous.So this research provides an excellent decision-making tool for investors.国家自然科学基金资助项目(60704042

吡非尼酮药物缓释载体PTMAc-PEG-PTMAc水凝胶制备与体外实验

【目的】以PTMAc-PEG-PTMAc三嵌段（PPP）水凝胶为吡非尼酮（PFD）药物缓释载体，评价其药物缓释性能。观察PFD载药水凝胶对人眼Tenon′s囊成纤维细胞（HTF）增殖抑制作用。【方法】制备PPP水凝胶；研究其溶胀率及其影响因素；光学显微镜观察水凝胶（载药与空载）中人眼Tenon′s囊成纤维细胞（HTF）的形态学改变；直接接触法进行PPP载药水凝胶进行体外释药实验。通过测定浓度、计算累积药物释放量，绘制出两种水凝胶体外药物释放曲线。CCK-8法检测不同浓度不同时间点水凝胶材料对细胞活力的影响及载药水凝胶体外抑制HTF增殖。【结果】PPP水凝胶成胶稳定。扫描电镜显示水凝胶呈现三维立体网孔状结构。水凝胶具有溶胀特性。溶胀率随水凝胶材料浓度增加而减少。在体外释药试验显示在前4d有明显的药物突释，此后缓慢释药直至第14天达到平衡。增加载药浓度，减少凝胶体积将明显增加药物累积缓释量；显微镜观察PPP水凝胶有抑制HTF细胞黏附作用；PPP水凝胶与HTF相互作用24、48、72、96h观察细胞活力分别为85.7%、93.0%、82.0%、81.6%，水凝胶不同方位HTF细胞形态不尽相同；水凝胶对细胞有抑制细胞黏附作用。两组不同载药浓度（1mg/mL和2mg/mL）载药水凝胶在24、48、72、96h这4个时间点细胞增殖抑制率分别为25.8%、21.8%、55.4%、25.6%；44.6%、35.9%、55.5%、31.4%。而1mg/mLPFD溶液在24、48、72、96h这4个时间点细胞增殖抑制率分别为28.9%、29.7%，7.8%、7.7%。【结论】PPP水凝胶具备良好药物缓释性能，载吡非尼酮水凝胶能明显抑制HTF增殖且较含等量药物溶液长效

The protective effects of compound sarcopyramis nepalensis wall on acute hepatic injury in mice

目的观察复方风柜斗草对四氯化碳(CCl4)引起的小鼠急性肝损伤的保护作用。方法将小鼠随机分为空白组、模型组、复方风柜斗草低剂量组(2.2 g/kg)、中剂量组(4.4 g/kg)、高剂量组(8.8 g/kg)和联苯双酯阳性对照组(0.2g/kg)。空白组与模型组给予1%羧甲基纤维素钠(CMC-nA)水溶液,其他组给予相应的药物,1次/d,连续灌胃给药10 d后,除正常组外,腹腔注射CCl4致小鼠急性肝损伤。检测肝组织中的超氧化物歧化酶(SOd)及血清中丙氨酸氨基转移酶(AlT)、天冬氨酸氨基转移酶(AST)的活性,同时检测血清中总胆红素(T-bIl)、直接胆红素(d-bIl)及肝组织中丙二醛(MdA)的水平,并计算肝脏指数。结果预先给予复方风柜斗草能显著降低急性肝损伤小鼠体内T-bIl、d-bIl、AlT、AST和MdA的水平,并升高肝组织中SOd活力。结论复方风柜斗草对CCl4致小鼠急性肝损伤具有保护作用,其机制可能与其所具有的抗脂质过氧化和清除体内过多氧自由基的作用有关。Objective To observe the protective effects of compound sarcopyramis nepalensis wall against tetrachloride( CCl4)-induced acute hepatic injury in mice.Methods The mice were randomly divided into normal group,model group,low dose compound sarcopyramis nepalensis wall group( 2.2 g / kg),medium dose group( 4.4 g / kg),high dose group( 8.8 g / kg),and positive control( biphenyldicarboxylate) groups( 0.2 g / kg).The mice were ig pretreated with compound sarcopyramis nepalensis wall and biphenyldicarboxylate once daily for consecutive 10 d,respectively.The mice in the normal and model groups were given 0.1% CMCNa,the water-solution instead.Then,acute liver injury in mice was induced by ip injection of CCl4.The activities of serum ALT and AST,hepatic SOD,and the level of serum T-BIL and D-BIL,hepatic MDA were also determined,the hepatic indices were calculated.Results The activities of ALT and AST,the level of T-BIL,D-BIL and MDA were significantly decreased by compound sarcopyramis nepalensis wall pretreatment,while activity of SOD in hepatic tissues was markedly increased.Conclusion Compound sarcopyramis nepalensis wall has protective effects against CCl4-induced acute hepatic injury in mice,and the mechanisms might be associated with its anti-oxidative and scavenging free radical activity

The Influence of Interlocking Labyrinth Seal Cavity Dimension on Leakage

Taking the labyrinth seal of the transmission gearbox for a certain type of high-power locomotives as researching object, twodimensional structured grid model of the interlocking labyrinth channel was set up by means of software GAMBI. The software Fluent was used in calculating labyrinth seal flow field and leakage flow rate, which were effected by the depth to width ratio and the tooth thickness to clearance ratio. The results showed that: the leakage decreased first and then increased with the increase of the depth to width ratio, the optimum depth to width ratio was about 0.9. Larger the width of cavity, the depth to width ratio effected leakage more obviously; the leakage increased first and then decreased slowly with the increase of the tooth thickness to clearance ratio

一种用于1,4-环己烷二甲酸二甲酯加氢生产1,4-环己烷二甲醇的催化剂及其制备方法

一种用于1，4-环己烷二甲酸二甲酯加氢生产1，4-环己烷二甲醇的催化剂，由主活性组分和助剂组成。主活性组分是氧化铜。助剂是由第一助剂组分和第二助剂组分两种类型助剂组分组合而成，第一助剂组分是氧化锌，第二助剂组分是氧化铝。也可以再加入含有锰、碱土金属化合物。本发明的催化剂可以用于1，4-环己烷二甲酸二甲酯加氢，生产1，4-环己烷二甲醇，催化剂中助剂组分的加入改善了催化剂的性能。并且使用原料原素少，制备工艺简单，成本低。带填

白化孟加拉虎的人工育幼

对1窝4只白化孟加拉虎从1日龄到70日龄的人工育幼全过程进行了详细记述,对代乳犬和幼虎的饲养,幼虎的脐部护理,视觉器官发育、听觉器官发育、牙齿发育、行为观察、体重增长情况、体长和尾长增长情况、室温判定等进行了全面记述和分析讨论。结果显示:幼虎4～6日龄脐带脱落,8～10日龄眼睛睁开,12～16日龄具有防御意识,50日龄能够看15～20 m,65日龄30颗牙齿基本长出。随着日龄增加,幼虎体重、体长、尾长均呈现线性增长,且在1月龄内增长速度受初生重影响很大