81 research outputs found
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ããã³èŸèãªã©ã«åœ±é¿ãäžããããšãå ±åãããŠããã(Clark and Hurst., 1970)ãããã®äžæ¯ã§ã¯ãæ¶ååšç³»ã«åœ±é¿ãäžããé«çšéã§ã¯è现èã«åœ±é¿ãäžãããšã®å ±åããã(Conning et al., 1969)ãããã®ããã«ããžã¯ã¯ããã®æ¯æ§åœ±é¿ã«ã€ããŠã¯å€ãã®ç 究ããªãããŠããããçºçã»çæ®æ¯æ§ã«é¢ããŠã¯ãå°æ°ã®å ±åãèŠãããã®ã¿ã§ãã(Kehara et al., 1968; Selypes et al., 1980; Ahmed et al., 1988)ããŸãããžã¯ã¯ããã¯ãèç€ãééããèåãžç§»è¡ãããã®ã®ããã®èåã«å¯Ÿããæ¯æ§ã¯ãæ¯äœã«å¯Ÿããæ¯æ§åœ±é¿ãšæ¯èŒãããšåŒ±ããã®ã§ãããšå ±åãããŠãã(Bus et al., 1975)ããååŠç©è³ªã®èåæ¯æ§ã®ææšã®äžã€ã«åè管ã«å¯Ÿãã圱é¿ã調ã¹ãæ¹æ³ããšãããŠããããèååè管ã®ç¹ç°çãªæ§è³ªãšããŠããã®æ¡åŒµç¶æã¯ããã¹ã¿ã°ã©ã³ãã£ã³E_2ã®äœçšã«ãã£ãŠç¶æãããŠãã(Coceani and Olley, 1973; Sharpe and Lasson, 1975; Heyman et al., 1976; Clyman et al., 1978; Monma et al., 1980)ããã®åè管ã®æ¡åŒµç¶æäœçšã¯ãããã¹ã¿ã°ã©ã³ãã£ã³ã®çåæãé»å®³ããéã¹ããã€ãæ§ã®æççè¬ã§ããã€ã³ãã¡ã¿ã·ã³çãæäžããããšã«ãã£ãŠãã©ããã®èååè管ãåçž®ããããšã確ãããããŠãã(Kantrowitz et al., 1975; Hong and Lewis, 1976)ããŸããã€ã³ãã¡ã¿ã·ã³ãçŽæ¥èåãžããããã¯æ¯äœãžæäž(èç€ãçµç±)ãããšããããž(Kirkpatrick et al., 1977; Levin et al., 1978; Clyman, 1980)ããã³ãŠãµã®(Shrape and Lasson, 1975)ã§ãåè管ã®åçž®ããããšãå ±åãããŠããããæšå¹Žããžã¯ã¯ããã¯åŠåš æ«æã®æ¯äœã«æäžãããšãã®åã®åè管ãåçž®ããããšãå ±åãããããããžã¯ã¯ããã®åè管ã«å¯Ÿããåçž®æ©åºã¯ãã€ã³ãã¡ã¿ã·ã³ãšã¯ç°ãªããããã¹ã¿ã°ã©ã³ãã£ã³E_2ãä»ãããã®ã§ã¯ãªãã匷ãè¡ç®¡åçž®ç©è³ªãšããŠç¥ãããŠãããšã³ãã»ãªã³ãé¢äžããŠããããšã瀺åãããŠãã(Takagi et al., 1999)ããã®ãžã¯ã¯ããã«ãããšã³ãã»ãªã³ãžã®åœ±é¿ãããžã¯ã¯ããã®çŽæ¥çãªãã®ãããããã¯éæ¥çãªäœçšã§ãããã¯æãããšãããŠããªãããããã§ãæ¬ç 究ã¯ããžã¯ã¯ãããã©ã®ããã«ãšã³ãã»ãªã³ã«äœçšããåè管ãåçž®ããããäœçšæ©åºã®è§£æãç®çãšããŠè¡ã£ããã第1ç« ã§ã¯ããžã¯ã¯ããã®èååè管ã«å¯Ÿããäœçšãæ€èšããããã«ãåŠåš 21æ¥ã®ã©ããã«ãžã¯ã¯ããã7mg/kgã®çšéã§ç®äžæäžãããã®åŸã®èååè管å
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Ansamycins Produced by Streptomyces sp. LZ35
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µæåç©äžå犻åŸå°7䞪å®èéçŽ ç±»ååç©,åå«éŽå®äžºgEldAnAMyCIn(1),17-O-dEMETHylgEldAnAMyCIn(2),HErbIMyCIn b(3),rEblASTATIn(4),17-O-dEMETHylrEblASTA-TIn(5),AuTOlyTIMyCIn(6),HygrOCIn A dErIVATIVE(7)ãç»è®ºååç©1~7å䞺éŠæ¬¡ä»è¯¥èæ ªäžå犻åŸå°,äžéŠæ¬¡ä»äžæ ªéŸéèäžå犻å°2ç§ç±»åçå®èéçŽ ãOBJECTIVE To study the chemical constituents of Streptomyces sp.LZ35.METHODS The constituents were isolated and purified by Sephadex LH-20 column,silicagel column and recrystallization,and their structures were identified by NMR and ESI-MS techniques.RESULTS Seven compounds were isolated and identified as geldanamycin(1),17-O-demethylgeldanamycin(2),herbimycin B(3),reblastatin(4),17-O-demethylreblastatin(5),autolytimycin(6),hygrocin A derivative(7),respectively.CONCLUSION Compounds 1-7 were obtained from the strain for the first time.Two types of ansamycins were isolated for the first time from Streptomyces sp.åœå®¶æ°åºé幎ç§åŠåºé(30325044);æè²éšç§åŠææ¯ç 究éç¹(é倧)项ç®(306010);å±±äžå€§åŠèªäž»åæ°åºé(2010TB016;2010TS072
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