前立腺全摘後のPSA再発に対する救済放射線療法の検討

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Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia

Background/Aim: Hyperthermia (HT), combined with chemotherapy, has been used to treat various types of cancer. This study aimed to investigate the HT-sensitivity of malignant and non-malignant cells, and then evaluate the combination effect of docetaxel (DTX) and a newly synthesized chromone derivative (compound A) with HT. Materials and Methods: The number of viable cells was determined using the MTT method. Cell cycle distribution was analyzed using a cell sorter, and DNA fragmentation pattern was detected using agarose gel electrophoresis. Results: Among 12 cultured cells, oral squamous cell carcinoma (OSCC), especially Ca9-22 cells, and myelogenous leukemia cells showed higher sensitivity to HT than lung carcinoma and glioblastoma cell lines, while normal oral cells were the most resistant. Cytotoxicity of DTX on Ca9-22 cells was maximum at 41-42°C and 45~60 min exposure to HT. DXT, compound A, and HT induced G2/M arrest of Ca-22 cells. Mild HT enhanced the DTX- and compound A-induced subG1 arrest, in a synergistic fashion. Conclusion: The combination G2/M blockers and mild-HT can potentially be used for the treatment of OSCC.This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license(https://creativecommons.org/licenses/by-nc-nd/4.0)

The Impact of Regulatory and Tax Changes on Alcoholic Beverages on the Structure of Demand for Alcoholic Beverages: Focusing on the 2003 Tax Rate Changes for Beer-Based Beverages

departmental bulletin pape

Observation results by the TAMA300 detector on gravitational wave bursts from stellar-core collapses

We present data-analysis schemes and results of observations with the TAMA300 gravitational-wave detector, targeting burst signals from stellar-core collapse events. In analyses for burst gravitational waves, the detection and fake-reduction schemes are different from well-investigated ones for a chirp-wave analysis, because precise waveform templates are not available. We used an excess-power filter for the extraction of gravitational-wave candidates, and developed two methods for the reduction of fake events caused by non-stationary noises of the detector. These analysis schemes were applied to real data from the TAMA300 interferometric gravitational wave detector. As a result, fake events were reduced by a factor of about 1000 in the best cases. The resultant event candidates were interpreted from an astronomical viewpoint. We set an upper limit of 2.2x10^3 events/sec on the burst gravitational-wave event rate in our Galaxy with a confidence level of 90%. This work sets a milestone and prospects on the search for burst gravitational waves, by establishing an analysis scheme for the observation data from an interferometric gravitational wave detector

Development of a method for sulfur isotope ratio determination of Antarctic ice core samples

第2回極域科学シンポジウム　氷床コアセッション 11月16日（水） 国立極地研究所 2階大会議室前フロ

Oxygen and Hydrogen stable isotope records from the Dome Fuji ice core over the past 720,000 years

第4回極域科学シンポジウム横断セッション：[IC] 極域アイスコア・地形地質・モデリングから迫る古環境変動とそのメカニズム11月13日（水） 国立極地研究所 ３階 ラウン

Variability of terrestrial materials during the past 700,000 years in the Dome Fuji ice core, Antarctica

第4回極域科学シンポジウム横断セッション：[IC] 極域アイスコア・地形地質・モデリングから迫る古環境変動とそのメカニズム11月13日（水） 国立極地研究所 ３階 ラウン