タマホマチ リョクナイショウ ジッタイ チョウサ ゼンコク 7チク リョクナイショウ エキガク チョウサ ノ イッカン トシテ

原発開放隅角緑内障,低眼圧緑内障等は無自覚で進行するため,病院統計ではその実態の把握が困雑であり,住民検診の必要がある。今回われわれは,全国規模で行なわれた緑内障住民検診の一環として,玉穂町住民40歳以上を対象に検診を行なった。その結果,一次検診では対象者1639人のうち1249人が受診して,受診率は76.2%であった。一次検診で,問診,屈折,矯正視力,眼圧,細隙灯,隅角,眼底撮影等の検査を実施し,この調査のための全国統一基準により,ニ次検診対象者147人を選択した。二次検診は,受診者は133人で,受診率は90.5%であった。二次検診では,眼圧,隅角,視神経乳頭の精査のほか,全員に視野検査を実施した。その結果,統一の診断基準により,85人(155眼)が高眼圧症を含め,緑内障およびその疑いと診断された。病型別では,低眼圧緑内障,原発開放隅角緑内障,原発閉塞隅角緑内障の順で,特に,低眼庄緑内障の緑内障全体に占める割合は,66.7%と従来の報告と比べ高率であった。玉穂町の緑内障頻度は2.72%で,病型別では,低眼圧緑内障1.80%,原発開放隅角緑内障0.48%,原発閉塞隅角緑内障0.36%,水晶体嚢性緑内障0.08%,高眼圧症0.84%であった。また,高齢になるほど緑内障の頻度は高くなることが示された。今回の調査では3人(6眼)を除きほとんどすべてが新規発見眼であり,多数の潜在患者の存在が推定される。本稿では,玉穂町における緑内障疫学調査の結果を示し,問題点に対して考察を加えた。journal articl

膵癌の術中照射 : 信州大学医学部附属病院における4年間の治療成績

Article信州医学雑誌 41(3): 205-210(1993)journal articl

THERMOLUMINESCENT RESPONSES OF Li3B7O12:Cu TO PROTON BEAM

A thermoluminescent (TL) phosphor Li3B7O12:Cu was irradiated by a proton beam at NIRS-HIMAC in Japan. Irradiation was performed at different water-equivalent depths using range shifters made of polymethyl methacrylate. The thermoluminescent responses of Li3B7O12:Cu were analysed, focusing on the TL efficiency and glow curve. The irradiated samples were heated from room temperature to 200°C at 0.16°C s−1. The high-temperature area of the glow curve under proton irradiation changed in comparison with that under 60Co gamma-ray irradiation. The relative TL efficiency of the main peak slightly varied between 0.8 and 1.1. The relationship between the relative TL efficiency of the main peak and the high-temperature area ratio (HTR) value, the relative TL ratio of the main peak to the high-temperature area, showed approximate linearity for proton dosimetry. Using correction based on the HTR method, the TL phosphor Li3B7O12:Cu can become a useful dosimetric tool for therapeutic proton beams

应用中草药提高华南虎免疫力的研究

本研究借鉴中草药提高人体免疫力的研究成果,通过分子生物学技术,测定中草药补肾治疗前后华南虎血清细胞因子IL-2、IL-2R、IL-6、IFNγ; 血清免疫球蛋白指标IgG、IgA、IgM及超氧化歧化酶SOD、谷胱甘肽过氧化物酶GSH-Px等生化指标,探讨中草药补肾治疗提高老龄华南虎免疫功能及抗氧化功能的机理,制定提高华南虎免疫力的中草药配方,为制定华南虎保护策略和遗传管理计划提供参考

Evaluation of base materials of TL slab Dosimeter for heavy-ion radiotherapy

In order to measure a three-dimensional dose distribution in X-ray radiotherapy, we developed TL slab dosimeter with new TL phosphor Li3B7O12(Cu), which has Zeff = 7.42 and a density of 1.01 g/cm3 and synthetic resin as binder. We can measure a 3D dose distribution easily and reliably using this detector. This detector showed a promising tool for QA/QC in advanced X-ray radiotherapies such as IMRT etc. In heavy-ion radiotherapies which shape precipitous dose distributions, it is also necessary to measure 3D dose distribution easily. To use TL slab dosimeter in heavy-ion dosimetry, it is essential to measure its LET dependence sufficiently. And it is necessary to evaluate the dosimetric water equivalence of this dosimeter for heavy ions. Previous studies showed that the relative TL efficiency of this TL phosphor decreased to about 20% at the Bragg-peak of carbon 290 MeV/u beams and the stopping-power ratio of this dosimeter to water for carbon ions was 0.87. These results were not good for application in heavy-ion radiotherapy. It was often reported that there is a relationship between the glow curve shape of general TLDs (such as LiF and BeO) and LET. Using this relationship of glow curve and LET, the relative TL efficiency can be corrected and we could apply TLDs to dose measurement in heavy-ion radiotherapies. In this study, in order to develop better TL slab dosimeter for heavy-ion radiotherapy using TL phosphors with the above characteristics, we evaluated the dosimetric water equivalence of several base materials for TL slab dosimeter. We chose several kinds of ceramics with heating resistance as the base material. We focused attention on stopping power, scattering power and nuclear cross section of these materials for heavy ions. We calculated these interactions using the Bethe formula, the Gottschalk formula and the Sihver formula. On the basis this evaluation we will develop the TL slab dosimeter for heavy-ion radiotherapy.Key words: TLD, TL slab dosimeter, heavy-ion radiotherapyHITSRS201