Design and Implementation of City FireFighting Mobile Communication and Command System Based on 3S

随着改革开放的不断深入和经济建设的飞速发展，诱发火灾因素急剧增多，各类火灾和其他灾害事故频繁发生，一旦救援不及，将会给人民的生命财产带来巨大的损失。目前，各个城市的公安消防指挥中心一般都通过车载电台、对讲机实现了消防指挥中心、消防车、灾害现场之间的语音通信，但消防车开往灾害现场时，特别是垮辖区救援时，不能快速找到灾害发生地点；先期到达现场的消防员，不能准确汇报出真实的灾害发生位置；救援时，由于消防员对消防水源所在位置不熟，无法快速出水救援；救援过程中，消防员只能通过语音手段汇报灾害现场情况，领导无法更准确地了解灾害情况，不便领导判断救援态势，给救援决策带来困难。因此，为了更有效地保护国家和人民...With the deepening of reform and opening up and rapid development of economic construction, induced a sharp increase in fires factors, various types of fires and other disasters occur frequently, once the rescue is less, will give cause tremendous losses of life and property of the people. Currently, all the city's public security fire command center generally through the car radio, walkie-talkie ...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201123047

Load Balancing Algorithm for Path Planning Based on Shared Memory

为满足前端对路径规划高并发服务需求,本文设计后台采用集群路径规划服务器来实现并行处理,以达到对前置Fast CGI服务器请求进行分流的目的。由此,本文提出基于共享内存的路径规划负载均衡算法,可根据不同路径规划服务器的性能差异,设置相应的加权系数,并按照加权调度算法,将任务交由合适的路径规划服务器来处理,以均衡所有路径规划服务器之间的负载能力,减少服务延迟,从而提高了路径规划服务的稳定性、扩展性、高可用性和执行的效率。To meet the front end on the path planning for high concurrency service needs,this paper designs background using cluster path planning server to realize parallel processing,in order to achieve the diversion for the prepositive Fast CGI server requests.Thus,this paper presents the load balancing algorithm for path planning based on shared memory,which can set the corresponding weighting coefficient based on the differences in the performance of different path planning server,and according to the weighted scheduling algorithm,the task to be processed by the appropriate path planning server.The result shows that this way can not only balance between all path planning server load capabilities,but reduce the server delay,so as to improve the stability of path planning service,expansion,high usability and execution efficiency

Impactfactors and optimization method on the separation of active components in licorice by micellar thin layer chromatography

第一作者Tel: 15012701322; E－mail: [email protected][中文文摘]目的:为甘草的胶束薄层色谱指纹图谱寻找最优胶束流动相。方法:首先采用单因子法,寻找影响甘草胶束薄层色谱的影响因素,在此基础上,采用控制加权可变步长单纯形优化法进行甘草胶束薄层色谱指纹图谱的流动相优化。结果:对甘草的胶束薄层色谱分离条件(表面活性剂的种类和含量、醇和酸改性剂的影响等)进行了实验,表明纯胶束薄层色谱的柱效较低,加入醇和酸类改性剂后柱效有明显提高。通过对改性胶束的进一步优化(控制加权可变步长单纯形优化法),得到优化的甘草改性胶束展开剂组成为:0.23 mol.L-1的SDS+16%(v/v)正丁醇+11%(v/v)甲酸。本研究对胶束薄层色谱的一些分离机理亦进行了探讨。结论:胶束薄层色谱的表面活性剂和各添加剂间存在交互作用,需采用合适的优化方法,才能达到分离中药材复杂活性成分群的目的。[英文文摘]Objective: To seek the best mobile phase of micellar thin-layer chromatography(MTLC)of licorice fingerprint.Method: Single impact factor of mobile phase in licorice MTLC fingerprint was tested individually and controlled weighted centroid simplex method was used finally to optimize the mobile phase of licorice MTLC fingerprint.Results: The selectivity of micellar TLC was studied for the separation of active components in licorice under various operation variables including concentrations of surfactant and co-surfactant,surfactant type,addition of acid modifier,et al.The results show that the low chromatography efficiency of micellar TLC could be improved by the addition of alcohol and acid modifier.Using controlled weighted centroid simplex ethod,optimization micellar TLC developing system of licorice was achieved which consists of 0. 23 mol·L－1 SDS,16%( v /v) n －butanol and 11% ( v /v) methyl acid.In addition,the separation mechanism of micellar TLC was also discussed.Conclusion:he appropriate optimization method should be tried to get the reliable mobile phase for the alternate impact of several parameters in MTLC国家自然科学基金资助项目(No.20235020

Impactfactors and optimization method on the separation of active components in licorice by micellar thin layer chromatography

第一作者Tel: 15012701322; E－mail: [email protected][中文文摘]目的:为甘草的胶束薄层色谱指纹图谱寻找最优胶束流动相。方法:首先采用单因子法,寻找影响甘草胶束薄层色谱的影响因素,在此基础上,采用控制加权可变步长单纯形优化法进行甘草胶束薄层色谱指纹图谱的流动相优化。结果:对甘草的胶束薄层色谱分离条件(表面活性剂的种类和含量、醇和酸改性剂的影响等)进行了实验,表明纯胶束薄层色谱的柱效较低,加入醇和酸类改性剂后柱效有明显提高。通过对改性胶束的进一步优化(控制加权可变步长单纯形优化法),得到优化的甘草改性胶束展开剂组成为:0.23 mol.L-1的SDS+16%(v/v)正丁醇+11%(v/v)甲酸。本研究对胶束薄层色谱的一些分离机理亦进行了探讨。结论:胶束薄层色谱的表面活性剂和各添加剂间存在交互作用,需采用合适的优化方法,才能达到分离中药材复杂活性成分群的目的。[英文文摘]Objective: To seek the best mobile phase of micellar thin-layer chromatography(MTLC)of licorice fingerprint.Method: Single impact factor of mobile phase in licorice MTLC fingerprint was tested individually and controlled weighted centroid simplex method was used finally to optimize the mobile phase of licorice MTLC fingerprint.Results: The selectivity of micellar TLC was studied for the separation of active components in licorice under various operation variables including concentrations of surfactant and co-surfactant,surfactant type,addition of acid modifier,et al.The results show that the low chromatography efficiency of micellar TLC could be improved by the addition of alcohol and acid modifier.Using controlled weighted centroid simplex ethod,optimization micellar TLC developing system of licorice was achieved which consists of 0. 23 mol·L－1 SDS,16%( v /v) n －butanol and 11% ( v /v) methyl acid.In addition,the separation mechanism of micellar TLC was also discussed.Conclusion:he appropriate optimization method should be tried to get the reliable mobile phase for the alternate impact of several parameters in MTLC国家自然科学基金资助项目(No.20235020

缺位与错位:“失灵的手”该伸向何方?

主持人:结合背景材料,请谈谈此次疫苗事件暴露了我国药品监管中存在着哪些问题?造成以上问题的根本原因是什么?朱为群:虽然外界对此次疫苗事件背后的具体监管情况缺乏信息,但有一点是肯定的,那就是监管机构是存在的,但是没有发挥作用。疫苗监管缺失的根本原因在于相关监管责任者缺乏对生命的起码敬畏,以及由此导致的监管机制的缺失和监管方式

监管与重罚:如何挽回被失信的民心?

主持人:从处罚结果来看,此次长春长生生物疫苗案件,吉林药监局收回其狂犬病疫苗药品GMP证书,停止该企业狂犬病疫苗生产及销售,暂停该企业所有产品批签发,并处以罚没款总计344.29万元。而对比美国一个疫苗产品出问题,企业会被罚得倾家荡产,同时受到监禁处罚。我国的处罚制度是否偏轻?将会带来什么后果

疫苗之痛:缺失的监管,谁该担责?

背景材料:2018年7月15日,国家药品监督管理局发布通告指出,长春长生生物冻干人用狂犬病疫苗生产存在记录造假等行为;同时,该公司生产的批号为201605014-01的\"吸附无细胞百白破联合疫苗\"经中国食品药品检定研究院检验,其疫苗有效性不符合规定。此外,武汉生物制品研究所有限责任公司生产的批号为201607050-2的百白破疫苗因分装设备短时间故障,导致待分装产品混悬液不

Enzyme from engineering strain and application in 1, 3-propanediol coupling-enzymatic catalysis

第一作者简介：彭益强（1973—），男，博士研究生。联系人：方柏 山，教授，博导，从事生物化工研究。E-mail [email protected]。[中文摘要]培养定向进化后的质粒保藏菌E.coli BL21(DE3)pLysS/PET-15b-dhaT’-24并进行质粒抽提,将抽提的质粒转化入感受态宿主细胞E.coli BL21(DE3)pLysS中得产1,3-丙二醇氧化还原酶的工程菌。工程菌经乳糖诱导后进行发酵培养获得酶活为182 U/mL的1,3-丙二醇氧化还原酶,最适反应pH值为10,pH值稳定范围为7.0～9.0,最适反应温度为55℃,温度稳定范围为30～45℃。利用工程菌产的1,3-丙二醇氧化还原酶进行转化3-羟基丙醛为1,3-丙二醇的反应,同时偶联甘油脱氢酶(由另一工程菌制备)转化甘油的反应进行辅酶NADH的再生,实现了1,3-丙二醇的双酶耦合的连续反应。由于来源于工程菌的双酶酶学性质相适应,反应连续进行34 h后,底物3-羟基丙醛的转化率达63.4%,产物1,3-丙二醇的产率达64.6%。 [英文摘要]Engineering strain was acquired by transforming directly evolved plasmid from the incubated conservation bacterium E. coli BL21（DE3）pLysS/PET-15b-dhaT’-24 to the host cell E. coli BL21（DE3）pLysS. The lactose induced engineering strain was fermented to acquire 1,3-propanediol oxidoreductase（PDOR）with 182 U/mL activity. The optimal reaction pH was 10 and the pH stabile range was 7.0—9.0. The optimal reaction temperature was 55 ℃ and stabile temperature range was 30 — 45 ℃ . 3-Hydroxypropionaldehyde （ 3-HPA ） was catalysed by the PDOR to produce 1,3-propanediol（1,3-PD）. The reaction was coupled with another reaction of glycerol dehydrogenase （GDH，acquired from another engineering strain）to realize NADH regeneration. Thus，1,3-PD coupling enzymatic catalysis was constructed. Due to the two enzymes from engineering strains showed suitable characteristics，the reaction was continued for 34 hours and 63.4% translation rate of 3-HPA，64.6% 1,3-PD production rate were acquired.国家863计划子课题(2006AA020103)，国家自然科学基金资助项目(20676048

HPV1618假病毒中和抗体检测方法的验证

通讯作者：李长贵 E-mail：[email protected] 作者简介：赵慧（1980-），女，助理研究员 主要从事病毒疫苗质量控制工作目的 应用假病毒中和法建立检测血清HPV16/18中和抗体滴度检测方法并进行验证。方法 分别采用不同批次假病毒以及不同代次细胞对不同滴度的HPV16/18阳性血清进行多次平行检测，考察这些因素对检验结果的影响；同时通过对抗HPV16/18双价阳性血清、抗HPV16单价阳性血清和抗HPV18单价阳性血清的检测进一步评估中和抗体检测法的准确性、特异性及重复性。结果 不同批次假病毒和不同代次细胞对检验结果的影响均在四倍范围内，此外该检测法的准确性、特异性、重复性均在可接受标准范围之内。结论建立的假病毒法可满足中和抗体效价检测的要求，可用于评价疫苗的免疫效果。国家高技术研究发展计划（2012AA02A402）；国际科技合作项目 (2010DFB30100

MSM光探测器的直流特性

在稳态条件下金属-半导体-金属(MSM)光探测器的光电流一维模型可以通过求解电流连续方程和传输方程来建立并求解。在这种条件下，器件内部的载流子分布情况和总体光电流可以得到解析解而不用数值方法求解。该文从电流连续方程和传输方程出发详细推导了这一过程，并将这一结果应用于具体的InGaAs MSM光探测器的直流等效电路模型上，取得了很好的效果