SIGNIFICANCE of SHRUBBERY DISTRIBUTION IN THE COASTAL ZONE FOR THE VEGETATION REGIONALIZATION ON HEAT STATUS IN FUJIAN PROVINCE

据对福建全海岸带选取8个地区含36处样地、480M2面积的灌丛群落调查数据，以地区间灌木种多频度相似性指数作地区聚类和排序分析，得到闽东南部和闽东北部两个地区组合，且它们依温度变化成有规律的分布格局，划分结果同福建省气候区划、福建省植被区划均基本吻合。另据以上地区灌丛群落的灌木地理成分及其种优势度分析，也都取得和地区聚类、排序相对应的结果，这均表明福建海岸带灌丛群落的分布在植被区划上具热量指示意义。This paper deals with the distribution chracteristics of shrub community From the coastal zone in Fujian Province.According to the agglomerative analysis between the similarity indexes of shrub species in 8 surveyed areas consisting of 36 plots,480 mZ From the coastal zone in Fujian, these shrub communities may be divided into two distribution groups,i.e.southeast Fujian group and northeast Fujian group.In addition,these dividing results are simi-lar to the division of Floristic geographycal elements of the shrub communities, and the divisionof climate and vegetation in Fujian Province

Intratumoral Delivery of a PD-1-blocking scFv encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade

恶性肿瘤已严重威胁人类健康和生命，现有的治疗手段远远未能满足临床需求。厦门大学研究团队联合浙江养生堂生物科技有限公司、养生堂有限公司进行协同攻关，研制出新一代肿瘤免疫治疗药物——“注射用重组人PD-1抗体单纯疱疹病毒”。研究发现，重组表达PD-1单链抗体的溶瘤病毒具有“双药合一”抗肿瘤的突出优势，提高肿瘤治愈率。相关成果于2020年3月3日以研究论文形式在线发表于Cancer Immunology Research（《癌症免疫学研究》）期刊，为指导新型溶瘤病毒的升级改造和突破肿瘤免疫耐受提供了新的思路，为重组表达PD-1单链抗体的溶瘤病毒药物运用于肿瘤临床治疗奠定了坚实的理论基础。 厦门大学公共卫生学院夏宁邵教授和黄承浩助理教授为该论文的共同通讯作者，博士生林超龙和任文峰为该论文的共同第一作者。【Abstract】Oncolytic virotherapy can lead to systemic antitumor immunity, but the therapeutic potential of oncolytic viruses (OVs) in humans is limited due to their insufficient ability to overcome the immunosuppressive tumor microenvironment (TME). Here, we showed that locoregional oncolytic virotherapy upregulated the expression of PD-L1 in the TME, which was mediated by virus-induced type I and type II interferons (IFNs). To explore PD-1/PD-L1 signaling as a direct target in tumor tissue, we developed a novel immunotherapeutic herpes simplex virus (HSV), OVH-aMPD-1, that expressed a single-chain variable fragment (scFv) against PD-1 (aMPD-1 scFv). The virus was designed to locally deliver aMPD-1 scFv in the TME to achieve enhanced antitumor effects. This virus effectively modified the TME by releasing damage associated molecular patterns (DAMPs), promoting antigen cross-presentation by dendritic cells, and enhancing the infiltration of activated T cells; these alterations resulted antitumor T cell activity which led to reduced tumor burdens in a liver cancer model. Compared with OVH, OVH-aMPD-1 promoted the infiltration of myeloid-derived suppressor cells (MDSCs),resulting in significantly higher percentages of CD155+ G-MDSCs and M-MDSCs in tumors. In combination with TIGIT blockade, this virus enhanced tumor-specific immune responses in mice with implanted subcutaneous tumors or invasive tumors. These findings highlighted that intratumoral immunomodulation with an OV expressing aMPD-1 scFv could be an effective standalone strategy to treat cancers or drive maximal efficacy of a combination therapy with other immune checkpoint inhibitors.This work was supported by grant 2018ZX10301404-001-002 from the National Science and Technology Major Project and grant 81571990 from the National Natural Science Foundation of China.该研究获得了国家自然科学基金、国家科技重大专项的资助

流化床中高水分煤的燃烧与排放试验研究

通过在一小型流化床中进行高水分煤的燃烧与排放的试验研究，表明水分含量和空气－燃料比对于高水分煤的燃烧与排放有较大影响。随着水分增加，流化床床温下降，ＮＯｘ、ＳＯｘ排放量也下降。空气－燃料比存在一最佳值，这时床温最高，而偏离此值，床温下降，随着空气量的增加，ＮＯｘ、ＳＯｘ排放量也增加。当空气－燃料比变化时，燃烧干煤与燃烧高水分煤有着类似的试验结果

水煤浆直流型低压雾化喷嘴

一种单孔直流型低压雾化喷嘴，由喷嘴、外套和输浆管组成，在喷嘴的周圈有用于注入空气射流的排孔。当煤浆射流由输浆管输入后，经高速气流多次雾化形成雾炬，达到利于燃烧的目的。特点是煤浆通道直径大不易堵塞，低压运行磨损小、用碳钢材料就可制造，降低了喷嘴成本，结构简单，雾化效果好，运行稳定、操作和维修方便，调节范围大，出力可由每小时几百公斤到每小时三吨

偏置射流火焰稳定方法及其装置

本发明公开了一种能够稳定和强化燃烧的方法和装置。它是利用空气燃料混合物以一定速度偏轴地喷入燃烧室，使在燃烧室内产生一较大高温回流区，点燃直接落入其中的燃料。燃烧装置是由燃烧室和位于燃烧室前端面的偏置喷口组成。喷口安置在前端面中心轴线以上的半部

偏置射流火焰稳定装置

本发明公开了一种低挥发份煤稳定和强化燃烧装置。该装置是由燃烧室和偏离轴线安装在燃烧室前端面的喷口、控制射流通道构成。喷口和控制射流通道均偏置于燃烧室水平中心线的下侧，且控制射流通道在喷口下方。由于喷口的偏置，以及通过喷口的主射流和控制射流的相互作用，在燃烧室内部形成高温回流区，使低挥发份煤粉和水煤浆均能稳定燃烧