Effect of edaravone on cerebral edema and lipid peroxidation in rats of cerebral hemorrhage

目的探讨依达拉奉对大鼠脑出血后脑水肿及脑组织氧化损害的影响。方法选取健康雄性清洁的SD大鼠150只,随机分为假手术组、对照组、治疗组,每组50只,分别于术后0.5、1、2、3、4 d 5个时间点对每组中不同10只进行观察。采用立体定向自体血注入法制作大鼠脑出血模型,检测3组并比较各时间点血肿周围脑组织含水量变化、丙二醛(MDA)含量变化及超氧化物歧化酶活力情况。结果假手术组和治疗组术后1~4 d各时间点血肿周围脑组织含水量均显著低于对照组(P<0.05);对照组在术后2d脑水肿达到最高值;假手术组、治疗组术后0.5~4 d各时间点血肿周围脑组织MDA含量均显著低于对照组(P<0.05);假手术组、治疗组术后0.5~4 d各时间点血肿周围脑组织SOD活力均显著高于对照组(P<0.05)。结论依达拉奉能明显改善脑出血大鼠血肿周围脑组织水肿,减轻脑出血大鼠脑组织氧化损害。Objective To discusse the effect of edaravone for brain tissue oxidative damage after cerebral hemorrhage through observing the hemorrhage rats back edema and the change of lipid peroxidation. Methods 150 healthy and clean male SD rats,were randomly divided to sham operation group,control group,treatment group,50 cases in each group,each group choose five time points,post operative 0. 5 day,1 day,2 days,3 days,4 days,observed different 10 rats at each time point. The intracerebral hemorrhage model was made by using the method of stereotactic autologous blood injection. The changes of water content,the content of MDA and the activity of superoxide dismutase were monitored in three groups at different time points. Results Surrounding the hematoma in the brain tissue around the hematoma after intracerebral hemorrhage in sham operation group,treatment group of postoperative day 1-4 days each time hematoma surrounding brain tissue water content was significantly lower than that in control group( P <0. 05); Control group after 2 days of cerebral edema and reached the highest value; Sham operation group and treatment group of postoperative half of the day to 4 days each time the content of MDA were significantly lower than in control group( P < 0. 05); Sham operation group and treatment group postoperative half of the day to 4 days each time the brain tissue SOD activity was significantly higher than control group( P < 0. 05). Conclusion The effect is obvious that edaravone for cerebral hemorrhage rats brain tissue around hematoma edema,reduce cerebral hemorrhage rat tissue oxidative damage.福建省医学创新课题项目(2015-1-85

Regulation of glucocorticoids on plasma tumor necrosis factor-α and interleukin-1β in brain trauma

目的研究糖皮质激素(glucocorticoid,GC)对脑外伤患者血浆肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)及白细胞介素1β(interleukin-1β,IL-1β)的调控作用,指导临床合理用药。方法随机选取2013年4月~2016年8月入住厦门大学附属第一医院神经外科的脑外伤患者120例,依随机表对照法随机分为激素组60例和非激素组60例,另外选择60例健康的体检者作为对照组。激素组给予常规剂量的地塞米松治疗1周。对照组不做任何处理。采用酶联免疫吸附法(ELISA)测定2组患者在治疗后第1、2、7、14天时血浆中TNF-α和IL-1β的含量。结果在第1、2天激素组的血浆中TNF-α和IL-1β的含量明显高于对照组(P<0.05),与非激素组差异无统计学意义。而在第7、14天明显低于非激素组(P<0.05),与对照组无明显差异。结论糖皮质激素对脑外伤患者TNF-α和IL-1β的调控具有明显的滞后性,损伤早期不能及时降低TNF-α和IL-1β的含量,在恢复期又使其降低,削弱了其对神经的保护作用,这可能会加剧患者的病情。Objective To study the regulation of glucocorticoid( GC) on plasma tumor necrosis factor-α( TNF-α) and interleukin-1β( IL-1β) in patients with brain trauma and guid rational drug use. Methods 120 patients with brain trauma were randomly selected from April 2013 to August 2016 in our hospital,according to a random table were divided into hormone group and non-hormonal group,60 cases of each group,another 60 healthy volunteers as control group. The hormone group received dexamethasone for one week,the control group with no treatment. The plasma TNF-α and IL-1βlevels on 1st,2nd,7thand 14 thdays were compared between two groups. Results On the 1stand 2ndday,plasma TNF-α and IL-1β levels in hormone group were significantly higher than control group( P < 0. 05),while there was no significant difference compared with non-hormone group. On 7thand14 thdays,the TNF-α and IL-1β levels in hormone group were significantly lower than non-hormone group( P < 0. 05),while there was no significant difference compared with control group. Conclusion The regulation of GC on TNF-α and IL-1β was hysteretic in traumatic brain injury patients,and can not reduce TNF-α and IL-1β content timely,but reduce their levels during the recovery period instead,reduce their protective effects of nerve,which could exacerbate the patient's condition.福建省医学创新课题(2015-1-85

微纳定位装置及其音圈电机

本实用新型提供了一种微纳定位装置及音圈电机。该音圈电机包括：底板，包括上底板与下底板；定子组件，包括轭部机构及四组Halbach阵列永磁体，轭部机构包括上部磁轭、中部磁轭及下部磁轭，上部磁轭、中部磁轭与下部磁轭共同围成上下两个气隙；每组Halbach阵列永磁体均包括至少两个径向充磁永磁体及至少两个轴向充磁永磁体，至少两个径向充磁永磁体与至少两个轴向充磁永磁体间隔设置，且径向充磁永磁体与轴向充磁永磁体沿轴向方向的宽度不相等；动子组件，安装于定子组件的两个气隙中；及支撑组件。基于双边Halbach阵列永磁体的聚磁效应与并联磁路，实现音圈电机的高精度与大推力的统一，使得音圈电机能够输出较大的推力，进而保证推力波动幅度仅为±0.21％

桂东北钨锡矿废弃地重金属污染类型及砷形态研究

作者简介：吴桂容（1970-），女，在职博士生，副教授，E-mail:[email protected]桂东北水岩坝曾是全国有名的钨锡矿集散地,矿产的停采带来大面积的废弃地,废弃地的治理成为当地面临的重要问题。为了确定废弃地重金属污染的类型,采取针对性的治理方法,对尾矿库区废弃地进行布点取样调查。结果发现,尾矿库区废弃地重金属砷严重超标,存在非常严重的生态风险,砷形态主要集中在生物有效性强的易溶态和铝结合态。尾矿库区废弃地成为一个潜在的重金属污染源,重金属砷污染治理显得尤为紧迫和必要。广西环境工程与保护评价重点实验室研究基金(桂科能0704K029

大连极紫外相干光源

先进光源的发展在前沿科学研究中发挥的作用越来越重要。近十年来,飞速发展的自由电子激光技术为科学家们提供了探索未知世界、发现新科学规律和实现技术变革的重要工具。建成的大连极紫外(EUV)相干光源的运行波段为50~150nm,单脉冲能量大于100μJ,且可提供10-12 s和10-13 s量级的超快激光脉冲,是我国第一台自由电子激光用户装置,并且是国际上唯一运行在极紫外波段的自由电子激光用户装置,在世界范围内为用户提供具有高峰值亮度和超短脉冲的极紫外激光。大连EUV相干光源是由国家自然科学基金委资助、由中国科学院大连化学物理研究所和上海应用物理研究所共同承担的重大科学仪器研制项目,目标是打造一个以先进极紫外光源为核心、主要用于能源基础科学研究的光子科学平台