Development of Radiolabeled tumor-specific targeting peptides for PET Imaging

多肽具有优良的药动学特性和生物学活性，因此在PET分子影像领域，多肽类分子影像探针展现出广阔的应用前景和优势。本课题利用AlF螯合法标记多肽，开发出一系列PET探针，并对相应探针进行体外及体内生物学评价。本课题具体研究内容可分为四部分。 第一部分，肝癌是最常见也是最致命的癌症之一，对于肝癌转移复发目前尚无行之有效的诊断、治疗方法。本研究通过固相法合成NOTA-G-TMTP1，并利用18F标记制得PET探针[18F]AlF-NOTA-G-TMTP1。[18F]AlF-NOTA-G-TMTP1标记产率为(25±6)%(n=5)，放化纯大于95%，放射性比活度大于11.1GBq/μmol，脂水分配...Due to their favorable pharmacokinetics and biological activities, small peptides labeled with positron emitting radionuclides have shown great potential in PET imaging. In this study, a series of 18F-labeled peptides were synthesized and radiolabeled with 18F using NOTA-AlF chelation method. The biological activities of these tracers were evaluated in vitro and in vivo. The thesis consists of fou...学位：博士后院系专业：生命科学学院_生物学学号：201317007

Fe-Crフラックスを用いたAlN単結晶の新しい溶液成長法の開発

Tohoku University博士（環境科学）要約のみthesi

鎌倉市百八やぐらの保存を目的とした亀裂計測

Causes and future risk of falling rocks were investigated at one yagura, a cave tomb, belonging to Hyakuhachi-Yagura Tombs, Kamakura City, because not a few falling rocks are observed there. In that yagura, the back wall and the ceiling are cut by a distinct fault, the strike of which is similar to that of the faults in Miura Peninsula, the surrounding area. Cracks, which are almost parallel or perpendicular to the fault, are also observed in and around the yagura. These cracks and bedding plane of the rock isolated blocks and finally became one of the main causes of the falling of rocks. So an attempt was made to measure the width of cracks with sensors. The width basically show periodicity correlated with temperature variation. However, at some cracks, the width unilaterally decreased without correlating with temperature variation. Such cracks should be elucidated carefully, considering the risk of crashing

Research on Epileptic EEG Signal Classification Based on Particle Swarm Optimization and RBF Neural Network

癫痫是一种危害人类健康的常见病和多发病之一，随时随地地发作给患者身心健康造成很大影响，在很多国家已经成为神经系统很受重视的高发疾病。脑电图是常用于辅助检测癫痫的一种重要手段，但是癫痫患者的脑电图不总是显示异常，所以依靠观察脑电图进行癫痫脑电识别依然存在问题，而且经过研究发现癫痫具有较强的随机性、非平稳性和非线性等特点，对癫痫疾病相关的研究带来较大的困扰。因此如何有效地提取脑电特征来表征癫痫脑电特征的信息，是进行癫痫诊断的首要问题。 针对癫痫脑电信号具有的随机性、非平稳性以及非线性等特点，本文提出了混合特征提取，将时域方法和非线性分析方法混合提取特征，然后采用粒子群优化算法进行优化选择，最后利...Epilepsy is one of the common diseases and frequently-occurring diseases which endangers the health of human beings and gets more attention in many countries. EEG is an important method used to detect the epileptic. However the EEG of epileptics don’t show abnormal all the time, it still exists problem to recognize the epileptic depending on the EEG only. Moreover, researchers have found that the ...学位：工学硕士院系专业：软件学院_计算机科学与技术学号：2432014115239

Investigation of inverted metamorphic multi-junction solar cell epitaxy and device

倒装多结太阳能电池相对于传统的Si基多结太阳能电池或传统的化合物三结太阳能电池具有更高的光电转换效率和更广泛的应用方式。本论文对外延关键技术及结构，如宽禁带隧穿结技术，PIN结构，应力缓冲层技术等在聚光倒装多结太阳能电池上的应用进行了研究。进一步对空间三结太阳能电池，空间四结太阳能电池，GaInP/GaInAs//Si键合三结太阳能电池及柔性倒装三结太阳能电池等进行了探索。取得主要成果如下： 1.采用AlGaAs/GaInP宽禁带隧穿结的电池短路电流为14.27A，相对于AlGaAs/GaAs窄禁带隧穿结的短路电流(13.72A)提升近4%，GaInP/GaAs双结倒装电池最终光电转换效率也...Inverted metamorphic multi-junction solar cell is potential for a high convention efficiency and extensive use relative to convensional Si base solar cell and III-V compound solar cell. In this dissertation, the effects of wide band tunnel junction, PIN structure, strain reducing layer on the concentrator solar cell were studied. On the other hand, triple-junction space solar cell, four-junction s...学位：博士后院系专业：物理科学与技术学院_凝聚态物理学号：201517006