胎儿肝脏21种化学元素含量的动态变化规律及其营养生理学意义

为探索胎儿肝脏化学元素的含量及其动态变化规律和营养生理学意义 ,通过分析 4～ 10月龄胎儿肝脏 2 1个化学元素的含量并与成人比较 ,将 2 1种元素的月平均值与胎儿月龄进行相关分析、分类。结果表明 ,胎儿生长发育过程中肝脏化学元素的含量呈不均匀的非稳定状态且随月龄而变化 ,其变化趋势可区分为与月龄增长呈显著正相关、显著负相关和相关不显著 3类。呈显著正相关元素的含量在胚胎 -胎儿 -新生儿、婴幼儿期由低向高变化 ,表明母体这些元素除供胎儿整体发育所需外 ,仍可使胎儿肝脏中的这类元素含量有所增加 ;呈显著负相关的元素由高向低变化 ,使单位组织质量中元素的含量很快减少 ,增加了组织对这类元素缺乏的敏感性 ;而相关不显著的元素可能不存在营养生理问

Highly Enantioselective Transfer Hydrogenation of Aromatic Ketones

手性芳香醇在制药工业上有重要的应用,因而利用芳香酮的对映选择性氢化制备相应的手性醇已引起人们极大关注.近10年来,用手性金属配合物为催化剂,利用种种有机物作氢源,实现芳香酮的不对称氢转移氢化取得了很大进展.但这些反应过程的催化活性仍然较低,底物酮与催化剂Enantioselective reduction of prochiral ketones with 2-propanol or formic acid catalyzed by chiral metal complexes has been developed as a synthetic method complementary to asymmetric hydrogenation in the past decade. However, these processes are necessary to be improved for practical use in organic synthesis because of low catalytic activity and insufficient enantioselectivity. In this paper, we wish to report an excellent catalytic system generated in situ from iridium complex IrCl(Ph3P)3 and chiral tetradentate di-aminodiphosphine ligand for asymmetric transfer hydrogenation of various aromatic ketones. For isobuty-rophenone transfer hydrogenation, the corresponding optically active alcohol was obtained in 93% yield and with up to 99% e. e. after 5 h at 28℃. Propiophenone was a better substrate with respect to catalytic activity and enantioselectivity in the presence of base as a co-catalyst. The conversion of propiophenone reached 95. 8% and the turnover number as high as 3 193 h-1. These results will provide a useful index for further designing practical chiral catalytic systems.国家自然科学基金(批准号:20073034,20171037);; 福建省科技厅重大科技项目基金(批准号:2002F016);; 厦门市科技局重大科技项目基金(批准号:3502Z20021044

Highly enantioselective transfer hydrogenation of aromatic ketones

Enantioselective reduction of prochiral ketones with 2-propanol or formic acid catalyzed by chiral metal complexes has been developed as a synthetic method complementary to asymmetric hydrogenation in the past decade. However, these processes are necessary to be improved for practical use in organic synthesis because of low catalytic activity and insufficient enantioselectivity. In this paper, we wish to report an excellent catalytic system generated in situ from iridium complex IrCl (Ph3P)(3) and chiral tetradentate diaminodiphosphine ligand for asymmetric transfer hydrogenation of various aromatic ketones. For isobutyrophenone transfer hydrogenation, the corresponding optically active alcohol was obtained in 93% yield and with up to 99 % e. e. after 5 h at 28 degreesC. Propiophenone was a better substrate with respect to catalytic activity and enantioselectivity in the presence of base as a co-catalyst. The conversion of propiophenone reached 95. 8 % and the turnover number as high as 3 193 h(-1). These results will provide a useful index for further designing practical chiral catalytic systems

硬骨鱼类的细胞核移植——鲫鱼细胞核和鲤鱼细胞质配合的杂种鱼

本文用细胞核移植方法,获得了不同属淡水硬骨鱼类之间的核质杂种鱼,即鲫鱼细胞核和鲤鱼细胞质配合的杂种鱼.从观察到的形态特征来看,不论在口须、咽喉齿、侧线鳞片数目、脊椎骨数目等方面,基本上相似于供体细胞核鱼(鲫鱼)的性状.这种杂种鱼已能饲养到性成熟阶段