Y型聚乙二醇干扰素琢-2b注射液治疗HCV基因2/3型慢性丙型肝炎患者疗效和安全性的多中心随机对照试验研究

目的以标准剂量的聚乙二醇干扰素(Peg IFN)α-2a联合利巴韦林作为阳性对照,评价新型试验药物Y型Peg IFNα-2b注射液联合利巴韦林治疗2型/3型慢性丙型肝炎(CHC)患者的疗效和安全性。方法采用多中心、随机开放、阳性药对照的Ⅲ期临床试验,筛选符合要求的2型/3型CHC患者,按照2:1的比例随机分配到Y型Peg IFNα-2b组和Peg IFNα-2a组,同时口服利巴韦林,疗程24 w,停药随访24 w。采用Abbott Real Time HCV Genotype II检测HCV基因型,采用Cobas Taq Man实时定量PCR法检测血清HCV RNA水平。详细记录不良事件。主要疗效指标为持续病毒学应答(SVR),并进行非劣效检验。结果本试验实际入组2型/3型CHC患者255例,实际治疗241例。全分析集(FAS)数据显示,158例试验组和83例对照组患者SVR分别为85.4%(95%CI 79.94%~90.94%)和79.5%(95%CI 70.84%~88.20%,P=0.2402);对符合方案分析集(PPS)人群分析显示,试验组和对照组患者SVR分别为87.9%(95%CI 82.45%~93.27%)和85.9%(95%CI 77.82%~94.01%,P=0.7060),率差的95%可置信区间均符合非劣效标准;对PPS人群分析显示,85.8%受试者获得了早期病毒学应答(RVR),RVR的阳性预测值为90.1%;试验组和对照组不良事件发生率相似,分别为95.6%和95.2%,严重不良事件发生率分别为3.8%和3.6%。结论应用Peg IFNα联合利巴韦林治疗2型/3型CHC患者,新型试验药物Y型Peg IFNα-2b具有与对照药物Peg IFNα-2a相似的疗效和安全性。国家科技部“十二五”重大专项(编号:2012ZX10002-003)；“重大新药创制”十二五科技重大专项(编号:2012ZX09303019)

自然环境中含颗粒物质流动的研究

自然环境中普遍存在着含颗粒物质的流动,如:暖云中的水滴,大气中的悬浮颗粒物(火山灰,风沙,花粉,微生物),水体中的泥沙,重金属等污染物,山地坡体上的泥石流等等。它们从排放

Numerical study of flocculation settling of cohesive sediment

盐度等因素对泥沙絮凝沉降的影响是本文的研究目的.考虑了泥沙颗粒在水中的多体相互作用, 以及颗粒间的XDLVO势.分析了盐度、泥沙浓度、Hamaker常数、水合作用对泥沙絮凝沉降的影响.获得的泥沙絮凝沉降速度的拟合公式与计算和试验相符, 对于工程实际有重要参考意

Multi-scale Calculation of Settling Speed of Coarse Particles by Accelerated Stokesian Dynamics without Adjustable Parameter

The calculation of settling speed of coarse particles is firstly addressed, with accelerated Stokesian dynamics without adjustable parameters, in which far field force acting on the particle instead of particle velocity is chosen as dependent variables to consider inter-particle hydrodynamic interactions. The sedimentation of a simple cubic array of spherical particles is simulated and compared to the results available to verify and validate the numerical code and computational scheme. The improvedmethod keeps the same computational cost of the order O(N log N) as usual accelerated Stokesian dynamics does. Then, more realistic random suspension sedimentation is investigated with the help ofMont Carlo method. The computational results agree well with experimental fitting. Finally, the sedimentation of finer cohesive particle, which is often observed in estuary environment, is presented as a further application in coastal engineering

黏性泥沙絮凝沉降的数值研究

The effects of salinity and other factors on flocculation settling are investigated in this paper. The many-body hydrodynamic interactions and XDLVO potential between sediment particles are taken into consideration. The effects of salinity, sediment concentration, Hamaker constant and hydration on settling speed are analyzed. The obtained fitting formula for flocculation settling speed accords with computational and experimental results and is of referential importance

一种水质急性毒性的检测方法及其装置

本发明属于环境污染检测技术领域，具体来说涉及一种水质急性毒性的检测方法及其装置。利用亚硝化细菌受到有毒物质抑制后，氧化铵离子的速率减小的程度来进行毒性分析。将细菌和选择性电极串联于流动分析系统中，首先将样品通入系统与细菌作用，而后转换介质，通入含铵离子的缓冲溶液，细菌氧化铵离子的速率可由铵离子选择性电极测得的电位信号变化计算得到。本发明采用介质转换方法，消除了基体效应，并避免了样品对电极的污损。采用铵离子选择性电极测定氨氧化速率，避免了利用氧电极测定溶解氧时其它好氧细菌的干扰

An algorithm for coarse particle sedimentation simulation by Stokesian dynamics

Coarse Particle sedimentation is studied by using an algorithm with no adjustable parameters based on stokesian dynamics. Only inter-particle interactions of hydrodynamic force and gravity are considered. The sedimentation of a simple cubic array of spheres is used to verify the computational results. The scaling and parallelism with OpenMP of the method are presented. Random suspension sedimentation is investigated with Mont Carlo simulation. The computational results are shown in good agreement with experimental fitting at the lower computational cost of O(N In N)

A water quality acute toxicity detection method and device thereof

本发明属于环境污染检测技术领域，具体来说涉及一种水质急性毒性的检测方法及其装置。利用亚硝化细菌受到有毒物质抑制后，氧化铵离子的速率减小的程度来进行毒性分析。将细菌和选择性电极串联于流动分析系统中，首先将样品通入系统与细菌作用，而后转换介质，通入含铵离子的缓冲溶液，细菌氧化铵离子的速率可由铵离子选择性电极测得的电位信号变化计算得到。本发明采用介质转换方法，消除了基体效应，并避免了样品对电极的污损。采用铵离子选择性电极测定氨氧化速率，避免了利用氧电极测定溶解氧时其它好氧细菌的干扰