Clinical observation on treatment of children amblyopia by Peibuganshen Huoxuetongluo method

目的观察培补肝肾活血通络法治疗儿童弱视的临床疗效。方法将符合纳入标准的儿童弱视患者74例134只眼,随机分为对照组（36例65只眼）和治疗组（38例69只眼）。对照组用1%阿托品眼膏点眼后验光配镜,同时采用遮盖方法及精细作业治疗;治疗组在戴镜、遮盖及精细作业的基础上,采用自拟培补肝肾活血通络方口服,以1个月为1个疗程,连续治疗3个疗程。比较两组视力和视力改善的起效时间,治疗后评价临床疗效。结果治疗组38例69只眼,基本痊愈23只眼,进步36只眼,无效10只眼,总有效率85.5%;对照组36例65只眼,基本痊愈13只眼,进步20只眼,无效32只眼,总有效率50.8%。治疗组疗效优于对照组（Mann-Whitney U检验,Z=-3.684,P〈0.001）。两组患者治疗后视力均明显改善（P〈0.05）;治疗后治疗组视力明显高于对照组（P〈0.05）。治疗组视力改善的起效时间短于对照组（P〈0.05）。结论培补肝肾活血通络法治疗儿童弱视的有效率明显高于常规基础治疗,且起效快,有临床应用价值。OBJECTIVE To observe the clinical effects of Peibuganshen Huoxuetongluo method on children amblyopia. METHODS Seventy-four children amblyopia cases（134 eyes） met the inclusion criteria were randomly divided into control group of 36 patients（65 eyes） and treatment group of 38 patients（69 eyes）. The patients in con-trol group were treated with 1% atropine and optometry glasses as well as cover up therapy and eyesight exercise; in addition to above mentioned methods, subjects in treatment group were given Peibuganshen Huoxuetongluo decoc-tion orally. Both groups were treated continuously for 3 courses of 3 months. The eyesight and effect onset time were compared between the two groups. After treatment, clinical curative effect was evaluated. RESULTS Among 38 cases（69 eyes） in treatment group, 23 eyes were recovered, 36 improved, 10 had no effects and the total effective rate was 85.5%; among 36 cases（65 eyes） in control group, 13 eyes were recovered, 20 improved, 32 had no effects and the total effective rate was 50.8%. The efficacy of treatment group was remarkably superior to the control group（Mann-Whitney U test, Z =-3.684, P〈0.001）. The eyesight of the treatment group after treatment was remarkably higher than that of the control group（P〈0.05）. The onset time of eyesight of the treatment group was shorter than that of the control group, and the differences had statistical significance（P〈0.05）. CONCLUSIONS Treating children amblyopia with Peibuganshen Huoxuetongluo method showed higher effective rate and shorter onset time in contrast to the routine basic therapy, thus it was of value in clinical application.四川省中医药管理局科研项目（2014-B-026