Interatomic many-body potential model in metal

在本文中,我们构造了金属Ta元素的Finnis-Sinclair型的嵌入原子势。并采用蒙特卡罗方法求解给出了此元素的多体势函数的参数。结果显示,本文拟合的参数能够较好的反映这种元素的结构特征和物理性质。福建省自然科学基金(批准号:Z0513004)资助的课

厦门国际马拉松赛发展研究

采用文献资料等研究方法,以我国获国际田联路跑标识赛称号的马拉松赛事为研究对象,通过对厦门市举办马拉松赛事的有利条件、发展现状、赛事成绩及奖励、赛事安全、赛事赞助5个方面进行系统分析,发现:厦门国际马拉松赛在引领国内马拉松发展趋向的同时,在赛事组织等方面也存在一些可改善的空间

太子参灵芝口含片的制备工艺研究

目的提取太子参多糖,灵芝中多糖及灵芝三萜成分,制成口含片并对其工艺进行评价。方法压制太子参灵芝口含片,并通过TLC薄层色谱法确定口含片中有效成分,通过测定片重差异,硬度测定仪测定含...福建省科技计划社会发展引导性(重点)项目(编号:2014Y0074

Single-crystalline and multiple-twinned gold nanoparticles: an atomistic perspective on structural and thermal stabilities

National Natural Science Foundation of China [51271156, 11204252]; Natural Science Foundation of Fujian Province of China [2013J06002]; Fundamental Research Funds for the Central Universities of China [2012121010]Morphologies of gold nanoparticles play an important role in determining their chemical and physical (catalytic, electronic, optical, etc.) properties. Therefore, a fundamental understanding of the morphological stability is of crucial importance to their applications. In this article, we employed atomistic simulations to systematically investigate the structural and thermal stabilities of gold particles with eight representative nanoshapes, including single-crystalline and multiple-twinned structures. Our investigation has revealed that the truncated octahedron and the octahedron possessed the best structural stability, while the tetrahedron and the icosahedron did the worst. Further analyses have discovered different thermal stabilities and diverse melting behaviors in these particles. Especially, an inhomogeneous melting of the icosahedron was disclosed, and the relevant mechanism was elucidated. This study provides significant insight not only into the experimental preparation of gold nanoparticles but also into the design of gold nanostructures with both high catalytic activity and excellent stability

Trisomy 21-induced Dysregulation of Microglial Homeostasis in Alzheimer’s Brains is Mediated by USP25

阿尔茨海默病（Alzheimer’s disease, AD）是一种最为常见的与记忆、认知能力退化相关的渐进性神经退行性疾病。唐氏综合征（Down’s syndrome, DS）是早发型阿尔茨海默病的一个重要风险因素，作为最常见的智力障碍遗传疾病，厦门大学医学院神经科学研究所王鑫教授团队揭示了治疗阿尔茨海默病和唐氏综合征新的治疗靶点，并且在小鼠模型上利用USP25小分子抑制剂成功地改善了阿尔茨海默病小鼠的认知功能，缓解了神经退行性病变的病理进程。该研究工作由王鑫教授指导完成，厦门大学医学院助理教授郑秋阳和博士生李桂林完成主要实验工作，王世华、朱琳、高月、邓青芳、张洪峰、张丽珊、吴美玲、狄安洁参与了部分研究工作。厦门大学医学院许华曦、赵颖俊和孙灏教授在研究过程中给予大力帮助和支持，清华大学董晨教授提供了Usp25基因敲除小鼠，厦门大学附属妇女儿童医院周裕林教授和郑良楷博士帮助收集了脑组织样品。Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer’s disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in combined murine DS-AD models. Overexpression of USP25, a deubiquitinating enzyme encoded by chromosome 21, results in microglial activation and induces synaptic and cognitive deficits, whereas genetic ablation of Usp25 reduces neuroinflammation and rescues synaptic and cognitive function in 5×FAD mice. Mechanistically, USP25 deficiency attenuates microglia-mediated proinflammatory cytokine overproduction and synapse elimination. Inhibition of USP25 reestablishes homeostatic microglial signatures and restores synaptic and cognitive function in 5×FAD mice. In summary, we demonstrate an unprecedented role for trisomy 21 and pathogenic effects associated with microgliosis as a result of the increased USP25 dosage, implicating USP25 as a therapeutic target for neuroinflammation in DS and AD.This work was supported by the National Natural Science Foundation of China (31871077, 81822014, and 81571176 to X.W.; 81701130 to Q.Z.), the National Key R&D Program of China (2016YFC1305900 to X.W.), the Natural Science Foundation of Fujian Province of China (2017J06021 to X.W.), the Fundamental Research Funds for the Chinese Central Universities (20720150061 to X.W.), and the BrightFocus Foundation (A2018214F to Yingjun Zhao). 该研究工作得到国家重点研发计划项目、国家自然科学基金、福建省自然科学基金、厦门大学校长基金的资助和支持

银鲫复合四倍体基因纽组成的鉴定

在银鲫的雌核发育(红鲤精子刺激)后代中检测到异源四倍体个体。本研究中,通过基因组原位杂交和45S rDNA的染色体荧光定位成功地鉴定了银鲫复合四倍体基因组中来自于银鲫和鲤鱼的染色体组。从银鲫基因组DNA中分离得到的45S rDNA的序列片段和银鲫及鲤鱼的基因组DNA分别用生物素(Biotin)或者地高辛(Digoxingenin)标记后,与银鲫和鲤鱼的有

动物眼睛的起源与进化研究进展

动物眼睛的起源与进化过程是人类在探索自然奥秘过程中遇到的一个非常有趣且引人注目的研究热点，目前这方面的研究已取得了丰硕的成果。从眼睛出现的过程、眼睛进化所需的时间、眼睛的单起源论、眼睛的类型与进化、光感受器与眼睛进化的关系、光感受器和视蛋白的类型与进化这6个方面简要概述了动物眼睛起源与进化的主要研究进展

金鱼Prox1基因的特征分析及表达定位

脊椎动物的Prox 1基因;与果蝇的转录因子prospero同源。该基因在晶体和眼睛中的表达模式表明;Prox1基因可能对眼睛的发育和功能的形成有重要作用。纯合的Prox1基因缺失的小鼠视网膜中的水平细胞发育不全;而且晶体纤维细胞不能正常延伸。为了探讨Prox 1基因在金鱼晶体发生过程中的表达模式;我们从金鱼眼睛SMART库中克隆了Prox1 cDNA;全长共2832b

Application of Monte Carlo Methods in Interatomic Many-body Potential Model

蒙特卡罗方法是求解非线性方程组的一种有效的方法.我们采用F inn is-S incla ir型的嵌入原子势,并运用蒙特卡罗方法拟合了金属T a的平衡晶格常数、结合能、弹性常数、空位形成能,给出了此元素的多体势函数的参数.In this paper,we construct the interatomic many-body potential for the tantalum metal in the framework of the Finnis-Sinclair model,and determine the functions by fitting to the equilibrium lattice constant,sublimation energy,elastic constants,and vacancy-formation energy of the pure tantalum metal using Monte Carlo methods.福建省自然科学基金(Z0513004