Research on Combinational Logic Circuits Design and Simulation Base on DNA Strand Displacement Reaction

高性能科学计算的需求不断增加，而传统电子计算机的元器件制作工艺已近极限，科学界正在寻找全新的计算模型，来突破现有计算体系的限制。生物计算以其并行性高、能耗低、信息存储量大等特点广受关注。DNA分子的双螺旋结构，以及Watson-Crick碱基互补配对原则，让其在电路设计中更加具有可操作性，基于DNA的分子计算模型的研究方兴未艾。其中，Winfree及其研究团队提出一种简单的seesaw模块，用以构建大规模逻辑电路。但由于化学反应的不完全性和动态性等特点，以DNA分子作为材料的电路还面临很多的问题。 本文首先对seesaw门模块进行了详细介绍，并进行仿真分析，发现随着seesaw门输出的增加，...Though the demand of high-performance scientific computing is increasing, traditional craft for computer components production has almost closed to the limitation. The scientific community now is looking for a new computing model, to break through the limitations of the existing computing system. The biological computing draws prevalent attention with its advanced characteristics like high paralle...学位：工学硕士院系专业：信息科学与技术学院_计算机系统结构学号：2302010115305

An Improved Region Growing Algorithm and Its Application in Coronary Artery Angiographic

冠状动脉造影过程中,由于人体骨骼、肌肉、器官等组织对X射线吸收程度不同,得到的冠状动脉造影图像亮度不均匀,传统的区域生长算法无法准确分割不均匀亮度的图像,而且种子点的选取需要人工交互,效率低下.针对这些问题,提出了一种改进区域生长算法,该算法自动生成一组种子点,种子点生长时,使用生长区域的局部平均值作为生长准则中的参数,最后使用医学影像计算与计算机辅助介入(MEdICAl IMAgE COMPuTIng And COMPuTEr ASSISTEd InTErVEnTIOn,MICCAI)准则对分割后的图像进行评价.实验表明,使用该算法对冠状动脉造影图像进行分割,能得到较好的结果,且不需要人工交互,提高了图像分割的效率和准确性.The intensity of coronary artery angiograms is non-uniform since different organizations,such as the bones,muscles,and organs,have different absorption of X-ray during angiography.The classical region growing algorithm has poor effect on these non-uniform intensity images,and it is also inefficient since the seeds must select manually.An improved region growing algorithm is presented by this paper,which not only produce seeds automatically,but also use a local parameter in growing criteria.Then we used Miccai criteria to evaluate the result of our algorithm.The efficacy of the approach is demonstrated with experiments.国家自然科学基金项目(61102137;60971085); 福建省自然科学基金项目(2011J01366;2010J01350

Modeling and Simulation for the Coronary Circulation of Ischemic Heart Disease

冠状动脉粥样硬化性心脏病发病率和死亡率都很高,对其进行建模与仿真有重要的医学意义.在左心循环系统的血流动力学仿真建模的基础上,结合冠状动脉粥样硬化的病理学特点及临床数据,建立描述心血管冠状循环与系统循环之间血液动力学关系的模拟电路模型,并运用MATlAb/SIMulInk对模型进行仿真,模拟冠状动脉粥样硬化性心脏病病理状态下的冠脉循环血流情况.模型通过修改参数,能模拟不同个体生理情况特征,仿真不同程度的冠状动脉狭窄的血流情况.仿真波形与动物实验结果相吻合,通过对血流储备分数(ffrMyO)的计算,也进一步验证仿真结果的正确性.It is acknowledged that the coronary atherosclerotic heart disease is the most widespread kind of heart disease.The researches on the field of modeling and simulation for the coronary circulation of CHD have great medicinal significance.Based on previous work on some simulation experiments of arterial system on left heart-arterial interaction coincide with the pathological characteristics and clinical parameters of CHD,a dynamic simulation model was built for the system of coronary circulation on CHD by using Matlab/Simulink,characterized the hemodynamic relations between the coronary circulation and systemic circulation.This model has been digitally simulated for coronary flow of different physiology and different degree of coronary artery stenosis of CHD by changing the parameter,the results were consistent with clinical observations of animal experimentation.The correctness of the results are further verified from the calculation of the conclusion of FFRmyo.国家自然科学基金项目(61102137;61071151;60971085);福建省自然科学基金项目(2011J01366;2010J01350

西南日本外帯の地殻構造 : 2002年四国―瀬戸内海横断地殻構造探査の成果 : 特集「地殻応力測定法の現状と解決するべき問題点」Part 2

In 2002, an integrated seismic survey across the overall Outer zone of Southwest Japan was conducted in Shikoku and Seto Inland Sea. The seismic line, which was more than 130km long, transected all geologic constituents of the superficial Outer zone of Southwest Japan. The survey successfully provided the first crustal transection of the Outer zone of Southwest Japan. The transection gives the following important information on the crustal structure. 14 The upper crust of the Outer zone is characterized by N-dipping accretionary complexes, which have a S-younging sequence, as expected by the surface geology. 2. The Median Tectonic Line (MTL), the northern boundary of the Outer zone, dips northward at about 40 degrees, and reaches the lower crust whose lower boundary exhibits an upward convex shape. 3. The lower crust of the Outer zone is only 30km wide from the lower termination of the MTL. Most of the Outer zone has no lower crust. 4. The Philippine Sea plate (PHS) changes its subducting angle from 10 to 25 degrees around the southern border of the lower crust