Experimental Effects Study of Total Flavonoids of Ajuga on Interleukin-1 and Tumor Necrosis Factor-α in Mesangial Proliferative Glomerulonephritis Rats

目的:探讨筋骨草总黄酮对系膜增生性肾小球肾炎(MSPgn)大鼠的干预作用机制。方法:采用改良慢性血清病MSPgn大鼠模型,于造模第5W末检测尿蛋白,将尿蛋白阳性者随机分为模型组、雷公藤多甙(TWP)组、不同剂量筋骨草总黄酮(TfA)组,另设正常对照组。于造模第6W起开始给药,6W后,测定各组大鼠的24 H尿蛋白定量、血生化和肾组织病理变化,放射免疫分析法观察TfA对MSPgn模型大鼠血清中白细胞介素-1(Il-1)、肿瘤坏死因子-α(Tnf-α)的影响。结果:TfA可显著降低尿蛋白,明显减小系膜区面积占毛细血管丛面积的百分比、减轻肾脏损害(P0.05)。模型对照组大鼠血清中Il-1(ng.Ml-1)、Tnf-α(ng.Ml-1)的表达明显高于正常对照组(Il-1 0.829±0.251 VS0.238±0.081,P0.05)。结论:筋骨草总黄酮对MSPgn大鼠有较好的治疗作用,降低Il-1和Tnf-α的水平,可能是其治疗作用机制之一。Objective:To investigate the effects of total flavonoids of Ajuga(TFA) in mesangial proliferative glomerulonephritis(MsPGN) rats and its mechanism.Methods:MsPGN rat was induced by the improved chronic serum sickness model after five weeks.The rats with positive urinary protein rats were randomly divided into model group,triptergium wilfordii polyglycosidium(TWP) group and TFA group with different dosage,normal rats wasere considered as the control group.MsPGN rats were treated with drugs since the sixth week;six weeks after succussfully modelingeeding six weeks later,all rats were detected 24 h urinary protein,and blood biochemistry,pathomorphological change in renal tissue,serum Interleukin-1(IL-1) and tumor necrosis factor-α(TNF-α) wasere measured by radioimmunoassay.Results:Compared with model group,TFA can significantly reduce the urinary protein,decrease BUN,Scr,TG,Tch,mitigate the morphological damage,and significantly increase TP(P0.05).The serum levels of IL-1 and TNF-α(ng·mL-1) in model control wasere significantly higher than that in normal control group;.With the intervention trherapy of high-dosage TFA,middle-dosage TFA and TWP,the expressions of serum IL-1 and TNF-α wasere significantly decreased compared with model control group(.The expressions of IL-1 and TNF-α in high-dosage TFA,and middle-dosage TFA groups wasere slightly higher than those in TWP group,with no significant differences(P>0.05).Conclusion:Total flavonoids of Ajuga has a therapeutic effect on MsPGN rats;Rreducing the expressions of serum IL-1 and TNF-α,which may be one of the mechanisms of MsPGN treatment.福建省卫生厅中医药科研重点课题资助项目(wzzsb0906); 陈可冀中西医结合发展基金·福建省中西医结合老年性疾病重点实验室开放课题资助项目(CKJ2008088); 福建中医药大学校管课题资助项目(X2009069

Experimental effects study of total flavonoids of Ajuga on nuclear transcriptional factor of kappa B in mesangial proliferative glomerulonephritis rats

目的探讨筋骨草总黄酮(TfA)治疗系膜增生性肾小球肾炎(MSPgn)大鼠后核转录因子-κb(nf-κb)及下游转化生长因子-β1(Tgf-β1)的变化。方法采用改良慢性血清病MSPgn大鼠模型,于造模第5周末检测尿蛋白,将尿蛋白阳性者随机分为模型组、雷公藤多甙(TWP)组、不同剂量TfA组。于造模第6周开始给药,6周后,测定各组大鼠的24 H尿蛋白定量、血生化和肾组织病理变化,MAXVISIOnTM即用型快速免疫组化一步法检测大鼠肾组织中nf-κb P65的表达,双抗体夹心法检测血清中Tgf-β1的变化。结果 TfA可显著降低尿蛋白,明显减小系膜区面积占毛细血管丛面积的百分比(P0.05)。模型对照组大鼠肾组织nf-κb P65、血清Tgf-β1的表达明显高于正常对照组[nf-κb P65:28.93±4.45 VS.4.51±0.96,P0.05).The renal tissue NF-κB(Integral optical density, IOD) and serum TGF-β1(pg/ml) in model control was significantly higher than that in normal control group, NF-κB p65 28.93±4.45 vs.4.51±0.96, P<0.01; TGF-β1:(247.63±51.55)pg/ml vs.(127.52±27.84)pg/ml, P<0.01; With the intervention trerapy of high-dosage TFA, middle-dosage TFA and TWP, the expression of NF-κB in renal tissue and TGF-β1 in serum was significantly decreased compared with model control group, NF-κB p65: 10.35±2.81, 15.21±4.71,11.70±3.97, P<0.01; TGF-β1:(181.96±52.93)pg/ml,(204.33±38.30)pg/ml,(188.07±42.92)pg/ml, P<0.05.Conclusion Reducing the expression of NF-κB and successive TGF-β1 may be one of the mechanisms of total flavonoids of Ajuga treatment on MsPGN rats.福建省卫生厅中医药科研重点课题(wzzsb0906); 陈可冀中西医结合发展基金·福建省中西医结合老年性疾病重点实验室开放课题资助项目(CKJ2008088); 福建中医药大学校管课题(X2009069

Industrial wireless network scheduling method and device based on loop power supply

本申请公开了一种基于回路取电的工业无线网络调度方法，包括：确定节点当前工作状态，工作状态包括发送状态和接收状态；根据节点当前工作状态判断节点剩余电量是否满足能耗需求，如果否，节点在回路中继续充电；如果是，唤醒节点，当节点工作状态为接收状态时，在预设接收时隙接收数据包；当节点工作状态为发送状态时，在预设发送时隙发送数据包。本发明实施例利用回路取电的方式从根本上解决了节点电量不足的问题，延长了长周期工业无线网络生存时间，并且回路取电可靠性高，从而提高了无线网络中数据传输的可靠性

Transceiver number based wireless network configuring method

本申请公开了一种基于多收发器的无线网络配置方法，包括：将当前网络划分为多个区域；将一个或多个网络节点分别配置在划分的区域中，每个区域配置一个网络节点，每个网络节点包含多个收发器；验证当前网络配置的收发器是否可以实时传输所有数据流，如果否，增加一个或多个网络节点的收发器数量，本申请提高了数据的传输速率和网络的吞吐量

Mixed key task based industrial wireless network data scheduling method

本申请公开了一种基于混合关键任务的工业无线网络数据调度方法，包括：获取网络中的数据流信息；根据数据流信息在网络中确定与第一数据流的路径重叠的路径重叠数据流；在路径重叠数据流中选取与第一数据流的关键级别相同的级别相同数据流；判断如果第一数据流在融合节点等待级别相同数据流到达融合节点之后，第一数据流是否能调度，如果是，在融合节点将第一数据流和级别相同数据流融合，传输融合后的数据流；否则，直接传输先到达融合节点的第一数据流。本发明实施例降低了网络冗余，减少了工业无线网络中信道冲突和传输冲突的数量，同时减少了节点传输产生的能量开销，并且提高了关键级别高的数据流的可靠性和可调度性

Mixed criticality scheduling for industrial wireless sensor networks

Wireless sensor networks (WSNs) have been widely used in industrial systems. Their real-time performance and reliability are fundamental to industrial production. Many works have studied the two aspects, but only focus on single criticality WSNs. Mixed criticality requirements exist in many advanced applications in which different data flows have different levels of importance (or criticality). In this paper, first, we propose a scheduling algorithm, which guarantees the real-time performance and reliability requirements of data flows with different levels of criticality. The algorithm supports centralized optimization and adaptive adjustment. It is able to improve both the scheduling performance and flexibility. Then, we provide the schedulability test through rigorous theoretical analysis. We conduct extensive simulations, and the results demonstrate that the proposed scheduling algorithm and analysis significantly outperform existing ones