A Probe into The Teaching Reform of The Course of Supply Chain Management

本文主要研究了随机需求下两阶段供应链的库存风险分担问题,首先给出随机需求背景下的供应链库存分散决策模型,并以此为基准通过引入订货协调率和追加订货价格两个参数提出了随机需求风险下的库存风险分担模型,最后通过算例来说明库存风险分担模型在供应链库存协调中是有效的。This article studied the inventory coordination of two-stage supply chain under stochastic demands.First,the decentralized decision model under random demands is proposed,then discusses the profit models of sharing inventory risk under adjustable quantity-rate and additional order price trategies in which the supplier partakes part of inventory risk.Finally,a numerical example illustrates that the inventory risk partaking strategy is valid in inventory coordination in supply chain.2013年度“中央高校基本科研业务费专项资金资助”(项目编号:2013221028)研究成

A Study on the Current Situation and Countermeasure of M Manufacturing Enterprise's Warehouse Management

本文主要对M制造企业仓储管理进行实际调查,通过从仓库布局、货物堆放、作业流程、员工专业能力等方面对该制造企业仓储管理的现状进行分析,并结合仓储管理相关的前沿理论和实践成功经验对其存在的问题提出相应的对策,以期提高该企业仓储管理水平。This article investigated M manufacturing enterprise's warehouse management.First, the current situation of the manufacturing enterprise's warehouse management is analyzed from the warehouse layout, goods stacked, operation procedure, employee professional ability, etc.Then corresponding countermeasures for the problems are put forward combined with warehouse management related theory and practice, in order to improve the level of the enterprise logistics warehouse management

Inhibitory effect of NRP-1mAb on the growth of gastric cancer cell BGC-823

目的观察自主研发的抗NRP-1b1/b2IgG单克隆抗体（NRP-1mAb）对胃癌BGC-823细胞生长的影响,并初步探讨可能的作用机制。方法实验室制备NRP-1mAb,采用SDS-PAGE检测纯度。采用0、25、100、200、400μg/ml NRP-1mAb培养胃癌BGC-823细胞,光学显微镜下观察细胞形态学变化;采用MTT法、集落形成实验、流式细胞术观察胃癌细胞BGC-823的增殖、集落形成和凋亡的情况;Western blotting法检测NRP-1mAb作用后Akt、p38、ERK、JNK信号蛋白磷酸化情况。结果SDS-PAGE检测显示,NRP-1mAb的纯度在95%以上。光学显微镜观察显示,NRP-1mAb作用后,BGC-823细胞形态呈凋亡改变。MTT实验显示,NRP-1mAb抑制BGC-823细胞的增殖作用呈浓度和时间依赖性（P〈0.01）。集落形成实验显示,不同浓度NRP-1mAb均能显著抑制BGC-823细胞的集落形成,其抑制率呈浓度依赖性（P〈0.01）。流式细胞术检测显示,不同浓度NRP-1mAb均明显促进BGC-823细胞凋亡,且大部分集中在早期凋亡。Western blotting检测显示,BGC-823细胞的Akt磷酸化受到抑制,ERK、p38、JNK的磷酸化水平无明显变化。结论NRP-1mAb能抑制胃癌细胞BGC-823的生长、促进凋亡,可能与抑制Akt磷酸化有关。Objective To observe the effect of NRP-1b1/b2 IgG monoclonal antibody（ NRP-1） on the growth of gastric cancer cell BGC-823,and to explore the possible mechanism of the antibody. Methods NRP-1mAb was prepared in laboratory,and the purity of antibody was detected by SDS-PAGE. Gastric cancer BGC-823 cells were cultured by 0,25,100,200,400 μg/ml NRP-1 mAb. The morphological changes of BGC-823 cells were observed by microscope. The proliferation,colony formation and apoptosis of gastric cancer BGC-823 cells were observed by MTT assay,colony forming assay and flow cytometry. The phosphorylation of related signal proteins was detected by Western blotting analysis. Results SDS-PAGE test showed that the purity of NRP-1mAb was above95%. Microscopy showed apoptotic changes of BGC-823 cells treated by NRP-1mAb. MTT assay showed that NRP-1mAb could inhibit the proliferation of BGC-823 cells in a time and dose dependent manner（ P〈0. 01）. Colony forming assay showed that different doses of NRP-1mAb could inhibit the colony formation of BGC-823 cells in a dose dependent manner（ P〈0. 01）. Flow cytometry showed that different doses of NRP-1mAb could promote the apoptosis of BGC-823 cells mainly at early apoptosis stage. It was found that the level of Akt phosphorylation was decreased after treated by NRP-1mAb,and there was no significant phosphorylation of ERK,p38 and JNK protein. Conclusion NRP-1mAb can inhibit the growth of gastric cancer cell BGC-823 and promote apoptosis,which may be related to the inhibition of Akt phosphorylation.厦门市科技计划创新资助项目（3502z20134026,3502z20144034

A Web-Based Environmental Decision Support System

本文基于浏览器/服务器模式开发了基于Web的环境决策支持系统(WEDSS),该系统由前台客户端、中间层及后台数据库等三层构成,其所有操作逻辑和事务逻辑由各层服务器完成。客户端只完成展示逻辑的功能,可大大提高系统的安全性、稳定性、可维护性和可扩展性,降低网络负载,提高与用户的交互能力,客户终端只要安装Web浏览器就能同时使用和参与环境系统的分析。该系统为城市规划者和政府管理人员更好地进行环境决策,解决当今人类居住、商务及工业发展三者之间的需求关系提供了一个有效途径,但由于环境问题和潜在解决方案流程在WEDSS系统中量化表述的难度,环境决策支持系统在推广方面还存在一定困难。The authors describe the development of Environmental Decision Support System based on Spatial Decision Support System(SDSS),which will help planner s and administrators to make right decision.The authors design and implement We b-Based Environmental Decision Support System by using browser-server technology,which will balance competing demands for residential,commercial and industria l development.Especially,it will also contribute to constructing economic acti vities of a harmonious society.But,the authors also point out that there are s ome difficulties for us to popularize WEDSS.国家社会科学研究基金项目《网上交易中信用体系问题研究》(项目编号:05BJY088)的部分研究成