Advance in research of water-proof liquid band-aid

创可贴是人们生活中最常用的外科用药。传统的创可贴即是一长形胶布,中间附以浸过药物的纱布,从而起保护伤口,暂时止血的作用。传统创可贴适合创伤较为表浅,伤口整齐干净、出血不多而又不需要缝合的小伤口使用。本文所要讲述的液体创可贴可用于大部分的外伤伤口,能够及时止血及防止病原微生物的感染。本文主要讲述了近些年刚刚出现的防水型液体创可贴,包括其主要的作用,材料组成及相关临床研究。Band-aid is the most commonly used surgical medication. The traditional band-aid is a longshaped adhesive,and the intermediate layer accompanied by soaking medicine gauze,thereby used for the wound and temporary hemostasis. The traditional band-aid is suitable for shallow trauma,small wound,clean and tidy wound,less bleeding and the wound that needs no suture. In this article we introduced a liquid band-aid that can be used for most of the traumatic wound,can timely stop bleeding and prevent microbial infection. We mainly described the waterproof liquid band-aid appeared in recent years,including its main effects,material composition and related clinical research

基于多组分评价的雷公藤提取物固体分散体的制备及体外表征

目的制备雷公藤提取物(ETW)固体分散体(ETW-SD),提高其体外溶出度。方法通过溶剂-熔融法,以聚乙二醇6000(PEG 6000)、泊洛沙姆188(F68)为载体制备ETW-SD。以雷公藤甲素、雷公藤内酯酮、雷公藤次碱、雷公藤红素以及雷公藤内酯甲为评价指标,通过体外溶出度、电子扫描电镜(SEM)、差示热量扫描(DSC)和X-射线衍射(XRD)对ETW-SD进行表征。结果 ETW-SD的最优处方为ETW-PEG 6000-F68(1∶2∶1)。与原料药相比,在60 min内雷公藤内酯酮、雷公藤甲素的溶出度分别提高了3.32倍,雷公藤次碱提高了2倍,而雷公藤红素和雷公藤内酯甲的溶出度均达到83%以上。福州总医院院立课题(2016L02);;福建省科技计划重大项目(2012I1001

Advances in preparation of mesoporous silica nanoparticles and its use as different functional drug

近年来,有越来越多的文献报道关于介孔二氧化硅纳米粒（mesoporous silica nanoparticles,MSN）作药物载体的研究。本文结合近几年国内外的相关文献,介绍了由Mobli公司合成的M41S系列,圣巴巴拉大学合成的SBA系列,以及中空介孔二氧化硅纳米粒这3种最常见的MSN的特点及制备方法,并举例介绍了MSN作为药物速释载体的相关研究,同时从p H敏感型、热敏型、光响应型三方面介绍了MSN作为药物控释载体的研究。从相关研究结果可以看出,将MSN作为药物的载体,鉴于其独特的介孔孔径、可调节的纳米孔道结构、易于功能化修饰的表面等特点,可以实现对药物的速释、缓释及控释释放。由此可见,选择将MSN作为药物的载体具有广阔的应用前景。In the past a few years, mesoporous silica nanoparticles (MSN) have attracted more and more attention for their application in drug delivery. The recent relative literature was used for reference to introduce the characteristics and preparation of M41S series MSN (synthesized by Mobil Corporation), the SBA series MSN (synthesized by Santa Barbara University), and hollow mesoporous silica nanoparticles. Examples were presented to introduce the use of MSN as immediate drug delivery carrier. The use of MSN as controlled drug delivery carrier (CDDC) was illustrated via pH-responsive CDDC, temperature-sensitive CDDC, and light-triggered CDDC. MSN showed great properties in immediate/sustained/controlled drug delivery system, in view of their unique mesoporous pore diameter, adjustable nano-channel, and surface easily to be modified. The selection of MSN as drug carrier has a broad application prospect. ? 2017, Chinese Journal of New Drugs Co. Ltd. All right reserved.福建省科技计划重点项目（2013Y0074

Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system

研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6 ± 1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2: 1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.福建省科技计划重点资助项目（2013Y0074

中药多组分缓释制剂体外释放评价体系的研究进展

目的：为找到更适合中药多组分的评价方法提供思路。方法：以＂中药多组分＂＂体外释放＂＂同步释药＂＂多指标＂＂Synchronized＂＂Release in vitro＂＂TCM multicomponent＂＂Multi-index＂等为关键词,组合查询2004年1月-2016年6月在PubMed、Elsevier、Springer Link、中国知网、万方、维普等数据库中的相关文献,对中药已知成分作为评价指标、中药指纹图谱在药物体外释放中的应用,以及中药化合物组、吸波面积法、质量权重系数法等方法在中药多组分缓释制剂体外释放中的应用进行综述。结果与结论：共检索到相关文献210篇,其中有效文献42篇。对于成分复杂的中药制剂,溶出度的测定选择其中某种已知的指标成分进行;选择中药组分制剂中的一种或几种药效成分的释放度作为评价指标,可反映中药组分制剂中特定成分的释放特征;以指纹图谱相关峰为指标,可更全面地评价中药多组分缓释制剂的体外释放行为;选择中药多组分制剂中的几种有效成分并结合中药制剂的指纹图谱进行评价中药多组分制剂的释药行为,既可反映多个成分的含量变化,又可反映中药复方整体的含量变化;基于中药化合物组的整体谱特征,采用卡尔曼滤波法,计算获得溶出介质中化合物的含量,能很好地反映中药多组分的释药行为;吸波面积法能考察中药所有成分的释放情况,对复方药物溶出度及体内药动学的研究有指导意义;质量权重法可为中药组分的整体性研究提供参考,但必须明确各成分在整体组分中所占的质量权重系数才能整合反映整体性质。福建省自然科学基金资助项目（No.2015J01491

Preliminary Study on Allelopathy of Pinus thunbergii

以大白菜作为受体;研究了黑松根、叶、枝条、树皮以及林下凋落物和表土浸提液对大白菜种子萌发及幼苗生长的化感作用。结果表明:各浸提液均可显著降低大白菜种子的发芽率、胚根长度及生物量;对平均发芽速率及胚轴长度则无显著影响;叶浸提液和凋落物浸提液在浓度为0.1 g/ml时可显著降低其发芽势;随浓度降低;影响则不显著;其余各浸提液则对发芽势无显著影响;在实验室条件下;叶浸提液对发芽率的影响最大;树皮浸提液对胚根生长抑制作用最强;而根浸提液在最终的生物量上抑制效果最为显著

Preparation and characterization of lyotropic liquid crystal and its application in drug delivery systems

脂质已经被广泛地用作多种药物传递系统中的主要组分,例如脂质体、固体脂质纳米粒、纳米结构脂质载体和溶致液晶。其中,溶致液晶具有高度的有序性和热力学稳定的内部纳米结构,从而具有作为持续释放药物模型的潜力。立方相和六角相的复杂结构已经被证实能够为活性药物原料（不同的相对分子质量和极性）提供由扩散控制的释放。此外,脂质的生物可降解性和生物相容性证明了其具有最小的毒性并且可应用于多种给药途径。因此,近几年对溶致液晶的研究已经吸引了很多研究者的关注。本文将对溶致液晶的结构特点、制备方法、表征进行综述。此外,溶致液晶作为药物传递系统的最新研究进展将被进一步讨论。Lipids have been widely used as main constituents in various drug delivery systems,such as liposomes,solid lipid nanoparticles,nanostructured lipid carriers and lyotropic liquid crystals.Among them,lyotropic liquid crystals have highly ordered,thermodynamically stable internal nanostructure,thereby offering the potential as a sustained drug release matrix.The intricate nanostructures of the cubic phase and hexagonal phase have been shown to provide diffusion controlled release of active pharmaceutical ingredients with a wide range of molecular weights and polarities.In addition,the biodegradable and biocompatible natures of lipids demonstrate the minimum toxicity and thus lipids are used for various routes of administration.Therefore,the research on lyotropic liquid crystalline has attracted a lot of attentions in recent years.This review will provide an overview of structural characteristics,preparation,exosyndrome,in particular the most current research progresses on lyotropic liquid crystal as drug delivery systems.军队医疗机构制剂标准提高科研专项课题（编号：14ZJZ17