Study of the Micro Loan Management System Based on SOA

面向服务的体系架构（ServiceOriented－Architecture，SOA）是基于“服务导向”的思想而产生的一种设计方法学，其核心思想是最大限度地运用信息资源中的“服务”以提高信息系统的适应性和效率。面向服务的体系架构是构造金融服务体系的理想方式，它能够为金融企业构建一个灵活、可扩展的基础架构，以便更好地支持随需应变的业务服务。近年来，小额贷款公司在试点的基础上，得到了快速发展，正成为金融业务中重要的组成部分。但是，在小额贷款公司自身的经营、风险的控制、政府针对小额贷款公司的监管等问题也逐渐出现，建立小额信贷管理系统成为了当务之急。 基于上述背景，本课题从实际需求出发，提出了构建基...Service Oriented-Architecture（SOA）is a theory that produces a design methodology, base on service-oriented thinking, its core idea is to maximize the use of information resources in the "service" to improve the adaptability and efficiency of information systems. Service-oriented architecture is an ideal way for financial service system construction. It is able to finance the enterprise to build a ...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X200923024

Tangut Fragments Newly Discovered at the National Library of China

This article introduces eight blockprint fragments in the Tangut script from the National Library of China. The fragments are mistakenly given shelf numbers with “Uighur Script 15,” because they have mingled with the other Old Uighur documents. One of the fragments belongs to a Tangut version of the Mūlasarvāstivāda Bhikṣuṇī Vinaya, a unique text among thus far known Tangut Buddhist scriptures: its backside was reused for a Tibetan Buddhist prayer. The other seven fragments all come from Volume 42 of the Mahāvaipulya Buddhāvataṃsaka Sūtra of the same version as the Lingwu 灵武 edition, printed in Hangzhou during the Yuan period. Although the provenance of these fragments cannot be fully elucidated, they were most probably discovered at the Dunhuang caves and brought to Beijing together with other Old Uighur fragments

犬细小病毒病诊疗报告

犬细小病毒病诊疗报告刘志圣，曹云峰，张卡（哈尔滨良种犬繁育中心）犬细小病毒病是由犬细小病毒引起的以出血性肠炎和非化脓性心肌炎为特征的急性传染病．幼犬发病率及死亡率极高。本文介绍我中心本病流行情况及防治体会。本病１９７８年在美国中西部首次流行并在短期内..

Homology modeling and molecular docking of xylitol dehydrogenase from Aspergillus Oryzae

【目的】研究米曲霉木糖醇脱氢酶基因的结构与功能。【方法】克隆测序来源于米曲霉的木糖醇脱氢酶(XdH)基因,利用SWISS-MOdEl和MOdEllEr对XdH进行三级结构模建,通过PrOCHECk和PrOSA2003对得到的4个目标模型进行评价,从中得到一个最佳模型。在同源建模的基础上,通过分子对接软件MOlSOfTICM-PrO,对辅因子进行对接,预测了XdH与nAd+、zn2+作用的相关残基。寻找底物木糖醇与XdH结合的可能活性口袋,用MOlSOfT模拟XdH与木糖醇的对接,预测了酶与底物作用的关键氨基酸残基。【结果】结构分析显示,米曲霉XdH含有醇脱氢酶家族锌指纹结构和典型醇脱氢酶rOSSMAnn折叠的辅酶结合域,属于MEdIuM-CHAIn脱氢酶(Mdr)家族。通过对接研究,预测了XdH与nAd+之间形成氢键的氨基酸有ASP206、Arg211、SEr255、SEr301和Arg303,这些氨基酸位于结合域,与zn2+形成氢键的氨基酸有HIS72和glu73,位于催化域,与天然底物木糖醇形成氢键的氨基酸有IlE46、IlE349、lyS350和THr351,位于催化域。【结论】所得信息对XdH分子定向改造、拓展米曲霉工业应用范围有重要意义。[Objective]We investigated the structure model and function of xylitol dehydrogenase from Aspergillus oryzae.[Methods] Xylitol dehydrogenase(XDH) gene from Aspergillus oryzae was cloned and sequenced.We constructed four tertiary structure models of XDH by homology modeling with Swiss-MODEL and Modeller and obtained the best quality model by evaluation of PROCHECK and Prosa2003.The dockings of NAD+,Zn2+ and xylitol with XDH were performed by Molsoft program.[Results] Structure analysis suggested that XDH was a member of medium-chain dehydrogenase/reductase(MDR) family.This was supported by the presence of the zinc-containing alcohol dehydrogenase signature and a typical alcohol dehydrogenase Rossmann fold pattern composed by NAD+ binding domain present in MDR superfamily.The molecular docking indicated that amino acid residues Asp206,Arg211,Ser255,Ser301 and Arg303 in XDH binding domain had hydrogen bonding with NAD+,His72 and Glu73 in catalytic domain had hydrogen bonding with Zn2+,Ile46,Ile349,Lys350 and Thr351 in catalytic domain had hydrogen bonding with xylitol.[Conclusion] These key amino acid residues might play a vital role in the XDH catalytic reaction and can instruct the further directed modification of XDH.国家自然科学基金((20676048);教育部留学回国人员科研启动基金(2010);福建省自然科学基金(D0810015);福建省高等学校新世纪优秀人才支持计划(07FJRC03);华侨大学基本科研业务费专项基金(JB-2R1112)---