Discussion on the on-line automatic detection technology for the full-color LED module

目前LED显示屏存在色差或者亮度差异源于单个模组在生产环节过程中控制不到位导致。本文提出了一种LED全彩屏模组的在线自动检测系统,包含显示屏自动定位控制,现场检测分析亮度均匀性,色度分布,质量判定分档等关键技术。该系统有助实现显示屏标准化检测,提高显示屏亮度一致性,提高生产效率及产量。The existence of the color or the brightness difference in the LED display panel is because of that the control of a single module is not in place occurring during the process of production. This paper presents an on-line and automatic detection system for the full color LED display module, including the automatic positioning control of the LED display, the detection and analysis of the brightness uniformity and the color distribution, and the quality evaluation and the quality grading among them. This system can realize the standardized detection of the LED display, improve its brightness uniformity, and increase the production effi ciency and the yield.福建省产学重大科技项目(编号:2013H6024

Advance in research of water-proof liquid band-aid

创可贴是人们生活中最常用的外科用药。传统的创可贴即是一长形胶布,中间附以浸过药物的纱布,从而起保护伤口,暂时止血的作用。传统创可贴适合创伤较为表浅,伤口整齐干净、出血不多而又不需要缝合的小伤口使用。本文所要讲述的液体创可贴可用于大部分的外伤伤口,能够及时止血及防止病原微生物的感染。本文主要讲述了近些年刚刚出现的防水型液体创可贴,包括其主要的作用,材料组成及相关临床研究。Band-aid is the most commonly used surgical medication. The traditional band-aid is a longshaped adhesive,and the intermediate layer accompanied by soaking medicine gauze,thereby used for the wound and temporary hemostasis. The traditional band-aid is suitable for shallow trauma,small wound,clean and tidy wound,less bleeding and the wound that needs no suture. In this article we introduced a liquid band-aid that can be used for most of the traumatic wound,can timely stop bleeding and prevent microbial infection. We mainly described the waterproof liquid band-aid appeared in recent years,including its main effects,material composition and related clinical research

Degradation of 2-methylisoborneol in water by hydroxyl radical

二-甲基异莰醇(2-MIB)是一种由蓝绿藻以及放线菌等微生物产生,具有桥环结构的饱和叔醇,在水中具有令人厌恶的土霉味,常规水处理工艺难以对其氧化; 降解.利用大气压强电离放电生成羟基自由基(·OH),对2-MIB进行氧化降解,确定了其氧化剂剂量效应、时间效应关系,并利用GC-MS对2-MIB; 氧化降解过程中间产物的分析,推断其氧化降解机制.结果表明:对初始浓度为150,300ng/L的2-MIB,分别投加总氧化剂TRO1.8,2.3m; g/L,接触反应6s去除率分别为96%和97.6%,处理后残余浓度低于10ng/L; (低于人类嗅阈值).在2-MIB水样中加入·OH淬灭剂叔丁醇(TBA)后,2-MIB的去除效果明显降低,证明氧化降解2-MIB的主要为·OH.另; 外通过对氧化降解过程中间产物分析表明,·OH能破坏2-MIB的桥环结构,并最终矿化生成CO_2和H_2O.2-methylisoborneol (2-MIB) produced by cyanobacteria and actinomycetes; is a saturated bicyclic-tertiary alcohol, which can cause earthy/musty; taste and odor in surface water. Moreover, 2-MIB is usually difficult to; be decomposed and removed by conventional water treatment process. In; this paper, hydroxyl radical (·OH) generated by a strong ionization; discharge process at atmosphere pressure was used to degrade 2-MIB in; water, of which the removal efficiency including dose effects and; contact reaction time were investigated. The intermediate products; formed in ·OH treatment process were analyzed by GC-MS, and the; oxidative degradation mechanism of 2-MIB by ·OH was discussed. Results; show that the removal rate for 2-MIB with initial concentration of 150; and 300ng/L could reach 96% and 97.6% within 6.0s, while the total; reactive oxidant (TRO) dose were 1.8 and 2.3mg/L, respectively. After; ·OH treatment, the concentration of 2-MIB in water was lower than 10ng/L; (lower than the human olfactory threshold). The degradation effects of; 2-MIB were obviously reduced by the ·OH scavengers tertiary butyl; alcohol (TBA), indicating that ·OH should be the main oxidant for 2-MIB; oxidative degradation. By analyzing the intermediates produced in the; oxidative degradation process, it was found that the bridge ring; structures of 2-MIB could be destroyed by ·OH and finally mineralized to; CO_2 and H_2O.国家科技支撑计划项目; 国家重大科研仪器研制项目; 科技部创新人才推进计划重点领域创新团队; 辽宁省重点实验室基础研究项

Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system

研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6 ± 1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2: 1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.福建省科技计划重点资助项目（2013Y0074

Advances in preparation of mesoporous silica nanoparticles and its use as different functional drug

近年来,有越来越多的文献报道关于介孔二氧化硅纳米粒（mesoporous silica nanoparticles,MSN）作药物载体的研究。本文结合近几年国内外的相关文献,介绍了由Mobli公司合成的M41S系列,圣巴巴拉大学合成的SBA系列,以及中空介孔二氧化硅纳米粒这3种最常见的MSN的特点及制备方法,并举例介绍了MSN作为药物速释载体的相关研究,同时从p H敏感型、热敏型、光响应型三方面介绍了MSN作为药物控释载体的研究。从相关研究结果可以看出,将MSN作为药物的载体,鉴于其独特的介孔孔径、可调节的纳米孔道结构、易于功能化修饰的表面等特点,可以实现对药物的速释、缓释及控释释放。由此可见,选择将MSN作为药物的载体具有广阔的应用前景。In the past a few years, mesoporous silica nanoparticles (MSN) have attracted more and more attention for their application in drug delivery. The recent relative literature was used for reference to introduce the characteristics and preparation of M41S series MSN (synthesized by Mobil Corporation), the SBA series MSN (synthesized by Santa Barbara University), and hollow mesoporous silica nanoparticles. Examples were presented to introduce the use of MSN as immediate drug delivery carrier. The use of MSN as controlled drug delivery carrier (CDDC) was illustrated via pH-responsive CDDC, temperature-sensitive CDDC, and light-triggered CDDC. MSN showed great properties in immediate/sustained/controlled drug delivery system, in view of their unique mesoporous pore diameter, adjustable nano-channel, and surface easily to be modified. The selection of MSN as drug carrier has a broad application prospect. ? 2017, Chinese Journal of New Drugs Co. Ltd. All right reserved.福建省科技计划重点项目（2013Y0074

金属矿千米深井高应力特性岩爆发生规律与防治措施研究

针对大红山铁矿进入千米深井开采后,在巷道、竖井和大断面硐室的基建开挖过 程中发生的多次不同程度的岩爆动力地压现象等严重的地压灾害问题,首先对千米深部 采区的高地应力特性进行了研究,得到了其深部高地应力处于超过亚临界深度的状态,但 还没有达到临界深度的总体评价结果;其次采用模糊综合评价法获得了不同岩性在不同 埋深的岩爆倾向性,得到了深部采区岩体总体上具有中等岩爆倾向性,在最深-40 m 水 平的局部,大理岩、片岩和磁铁矿的岩爆倾向性趋于强烈的结论;其次全面统计了基建过 程中发生的岩爆案例,获得了岩爆发生与埋深、地应力、岩性等的关系与规律,得到了岩爆 数量随埋深的增加呈指数关系增加的规律;最后提出了易爆岩层巷道与硐室的岩爆动力 地压灾害的防护措施.国家自然科学基金项目（51674218）国家重点研发计划项目（016YFC0600702）

中药多组分缓释制剂体外释放评价体系的研究进展

目的：为找到更适合中药多组分的评价方法提供思路。方法：以＂中药多组分＂＂体外释放＂＂同步释药＂＂多指标＂＂Synchronized＂＂Release in vitro＂＂TCM multicomponent＂＂Multi-index＂等为关键词,组合查询2004年1月-2016年6月在PubMed、Elsevier、Springer Link、中国知网、万方、维普等数据库中的相关文献,对中药已知成分作为评价指标、中药指纹图谱在药物体外释放中的应用,以及中药化合物组、吸波面积法、质量权重系数法等方法在中药多组分缓释制剂体外释放中的应用进行综述。结果与结论：共检索到相关文献210篇,其中有效文献42篇。对于成分复杂的中药制剂,溶出度的测定选择其中某种已知的指标成分进行;选择中药组分制剂中的一种或几种药效成分的释放度作为评价指标,可反映中药组分制剂中特定成分的释放特征;以指纹图谱相关峰为指标,可更全面地评价中药多组分缓释制剂的体外释放行为;选择中药多组分制剂中的几种有效成分并结合中药制剂的指纹图谱进行评价中药多组分制剂的释药行为,既可反映多个成分的含量变化,又可反映中药复方整体的含量变化;基于中药化合物组的整体谱特征,采用卡尔曼滤波法,计算获得溶出介质中化合物的含量,能很好地反映中药多组分的释药行为;吸波面积法能考察中药所有成分的释放情况,对复方药物溶出度及体内药动学的研究有指导意义;质量权重法可为中药组分的整体性研究提供参考,但必须明确各成分在整体组分中所占的质量权重系数才能整合反映整体性质。福建省自然科学基金资助项目（No.2015J01491

环保高效聚酰胺阻燃剂的研究进展

综述了环保高效聚酰胺阻燃剂,如磷系、氮系、膨胀型和无机填料型四类阻燃剂对聚酰胺阻燃性能的影响,并进一步分析了环保高效阻燃聚酰胺的发展前景

一种适用于真空辅助成形工艺的万用模具

本发明公开了一种适用于真空辅助成形工艺的万用模具，包括模具成形模块和扫描测控模块；所述模具成形模块包括：多个伸缩单元，规则排布形成成型区域；柔性模具面板，位于成型区域，底面与所有伸缩单元的输出端连接；所述扫描测控模块包括：控制单元，根据接收的模型数据控制多个伸缩单元的输出端位置以使柔性模具面板形成所需的模具表面；扫描单元，布置在所述柔性模具面板的上方用于收集模具面成形数据并反馈给控制单元；本发明具有成形速度快，成形精度高，并且可以多次反复使用的优点，解决了用于真空辅助成形工艺的传统玻璃钢模具成形工艺复杂，制作周期长，不可重构，浪费材料等问题

基于深度学习的MRI脑卒中病灶分割方法综述

脑卒中病灶自动分割方法成为近几年的研究热点。为了全面研究用于MRI脑卒中病灶分割的深度学习方法的现状，针对脑卒中治疗的临床问题，进一步阐述了基于深度学习的病灶分割的研究背景及其挑战性，并介绍脑卒中病灶分割的常用公共数据集（ISLES和ATLAS）。然后，重点阐述了基于深度学习的脑卒中病灶分割方法的创新与进展，从网络结构、训练策略、损失函数这3个角度对研究进展进行了归纳，并且对比了各种方法的优缺点。最后，讨论了该研究存在的困难和挑战以及未来的发展趋势