Neuropreotective effects and mechanism of regulating glutamate transporters in the mice model of Parkinson's disease

帕金森病（Parkinson’sdisease，PD）是一种中老年常见的神经系统变性疾病，兴奋性毒性作用是PD发病的关键机制，谷氨酸转运体通过摄取谷氨酸减轻兴奋性毒性效应。研究表明，通过上调谷氨酸转运体的表达，可以减弱兴奋性毒性对神经系统的损伤，从而保护多巴胺神经元，改善PD模型小鼠的运动行为障碍。因此，本课题主要研究谷氨酸转运体在PD发病中的调控策略，探讨通过提高谷氨酸转运体来治疗PD的可能性，分为两部分简述如下。 一、雷帕霉素在PD模型小鼠中上调谷氨酸转运体和IL-6的表达MPTP小鼠模型是一种公认的PD小鼠模型，雷帕霉素可以小鼠保护多巴胺神经元免受MPTP的损伤，我们的研究证明雷帕霉素...Abstract Parkinson's disease (PD) is a common neurodegenerative disease, which is mainly appeared in the middle aged and elderly people, and glutamate excitotoxicity contributes significantly to the pathogenesis of PD. Glutamate transporter attenuates glutamate excitotoxicity via glutamate uptake. Studies have shown that upregulation of glutamate transporters could weaken excitotoxic damage to th...学位：博士后院系专业：生命科学学院_生物学学号：201517005

The Applicability of Internal Rating-Based Approaches in china Commercial Bank Credit Risk Management

本论文旨在探讨巴塞尔新资本协议所提出的全面管理银行风险的计量标准、技术方法和制度要求以及它倡导的商业银行用于加强银行风险管理水平的内部评级法（IRB）在我国的可行性，为提高我国商业银行的风险管理水平提供一条参考路线。 本文介绍了巴塞尔新资本协议的主要内容以及新协议的内部评级法，探讨了将内部评级方法应用到以下七个方面的具体途径：制定贷款审批权限结构、贷后管理、贷款组合报告与分析、设定风险限额、确定贷款损失准备金、风险定价、资本分配与绩效评估。文章借鉴了新资本协议所包含的银行风险管理理念，以新资本协议提出的风险管理标准和方法为参照，以我国的商业银行为样本，以应用内部评级法来提高我国商业银行的风险...This article discusses the comprehensive guide for bank credit risk management provided by Basel Capital AccordⅡ,which includes the standard of measurement, the method of technology and the require of system, and the feasibility of Internal Rating-Based(IRB) Approaches in Chinese banks. The main aim of this thesis is to explore a way of improving the credit risk management for Chinese commercial b...学位：工商管理硕士院系专业：管理学院工商管理教育中心（MBA中心）_工商管理硕士(MBA)学号：S20041507

Research progress on the objectification, quantitation and standardization of tongue manifestation in traditional Chinese medicine

舌诊是中医诊断学的重要组成部分,舌象在中医临床治疗中具有重要的诊断意义与辨证价值。传统中医舌象易受主客观因素影响,难以客观化、定量化、标准化,严; 重制约舌象临床应用及发展。随着医学、计算机等现代技术的迅猛发展,中医舌象客观量化研究取得了长足进步,并被应用于基础及临床研究。文章对近几年中医舌; 象采集分析系统、舌象定量化研究、现代仪器应用与舌象基础研究进行概述,为舌象应用于临床治疗提供客观、科学的思路与方法。Tongue diagnosis is an important part of traditional Chinese medicine; (TCM), and the tongue manifestation is also important in the diagnosis; and syndrome differentiation in TCM clinical treatment. However, due to; the lack of objective, quantitative and standardized valuation, with it; being susceptible to subjective and objective factors, the application; and development of traditional tongue diagnosis is limited for a long; period. Recently, with the rapid development of medical and other modern; technology, the objectification, quantitation and standardization of TCM; tongue manifestation have been received great progress, including the; progress in basic and clinical researches. Recent researches on the; tongue image acquisition and analysis system, the quantitation of tongue; manifestation, the application of modern instruments and the basic; research in tongue manifestation were reviewed to provide certain; objective and scientific ideas and methods for TCM tongue manifestation.教育部新世纪优秀人才支持计划; 中国博士后科学基金面上项

基于图像仿真处理的光学元件检测

基于图像拼接与处理来实现非球面光学元件的初步检测,CCd摄像头首先将采集到的视频信号数据经dM642芯片转换成yuV格式,接着将y信号(灰度信号)经JTAg口运用rTdX(rEAl-TIME dATE EXCHAngE)技术传输到主机端,主机端利用MATlAb处理接收到的图像灰度数据,采用HArrIS角点算法提取出图像角点,运用归一互相关法对角点进行匹配并拼接图像,最后运用SObEl算法和CAnny算法对拼接后的图像进行轮廓提取处理,能有效观测到大尺寸光学元件表面裂纹、划痕等缺陷分布,可以验证这是一种有效的非球面光学元件进行精密加工前的检测方法

基于调控脑肠轴探索解毒化瘀汤改善阿尔茨海默病小鼠认知功能的机制

目的研究解毒化瘀汤(黄连解毒汤加味方)对阿尔茨海默病(AD)模型小鼠学习、记忆障碍的影响及调控机制。方法侧脑室定位注射寡聚化Aβ42制备AD小鼠模型,灌胃给予黄连解毒汤、低剂量或高剂量解毒化瘀汤3周,多奈哌齐灌胃作为阳性对照。3周后,水迷宫、T迷宫、Y迷宫等检测小鼠学习、记忆功能;超高效液相色谱质谱联用(UPLC-Q-TOF/MS)分析比较黄连解毒汤原方和解毒化瘀汤的化学成分组成;飞行时间质谱联用技术(GC-TOF/MS)检测不同组别小鼠海马代谢物质的变化;16S rDNA检测不同组别小鼠肠道菌群多样性变化;Western印迹和免疫组化等手段检测信号通路表达变化。结果相较黄连解毒汤组,高剂量解毒化瘀汤显著改善了AD模型小鼠的学习、记忆障碍。UPLC-Q-TOF/MS结果显示,与黄连解毒汤相比,在解毒化瘀汤中,谷氨酸和天冬氨酸等氨基酸含量更丰富。分子生物学结果提示,解毒化瘀汤上调了AD模型小鼠海马NMDA受体亚基(NR1,NR2A和NR2B)的表达。基于GC-TOF/MS的代谢组学检测结果表明,相较黄连解毒汤,解毒化瘀汤显著提高了AD模型小鼠海马的腺苷水平。结合分子生物学,解毒化瘀汤同时也上调了腺苷下游的ATPase/AMPK信号通路。16S rDNA肠道菌群检测结果表明,解毒化瘀汤调控了AD模型小鼠肠道Firmicutes,Bacteroidetes,Proteobacteria等菌属的多样性。通过对代谢组学和肠道菌群进行的相关性分析,最终鉴定出Dorea是响应解毒化瘀汤上调AD模型小鼠海马腺苷水平的肠道菌属。结论相较黄连解毒汤原方,解毒化瘀汤显著改善AD模型小鼠的学习、记忆障碍,通过调控NMDA/ATPase/AMPK信号通路上调AD模型小鼠海马腺苷和肠道Dorea菌属水平,重塑大脑和肠道的沟通。上述研究提示,解毒化瘀汤可能是治疗AD的新型有效药物。国家自然科学基金(81704130)广州市科技计划项目(201904010238)福建省自然科学基金(2017J05139)广东省自然科学基金(2017A030310643)广州医科大学科研启动经费(B185006002047

Design and Implementation of Intelligent Home Control System Based on Android and Arduino

作为时下最炙手可热的移动应用端操作系统,Android以其显著的开放性、便于开发的灵活性、能够与Google应用的无缝对接性及丰富的第三方软硬件; 资源等成为智能应用系统不可或缺的组成部分;Arduino单片机系统以其开源的电子原型平台、灵活便捷的设计和丰富的传感器资源等被广泛应用。其与Ja; va和C语言相类似的基于; Wiring/Processing的语言开发环境更是受到越来越多的电子爱好者和开发者的青睐。本文以移动手机安卓系统为无线控制终端,结合Ardui; no单片机系统,设计并实验仿真了一款基于Android与Arduino的智能家居控制系统,以控制; LED灯示例,通过网络http传输控制指令到Arduino单片机系统,Arduino根据所接收到的指令,控制不同的家居电器完成所要求的工作任务。; 仿真实验表明,文章所设计方法行之有效,可以灵活的运用到日常家居电器设备,提供了一种智能家居系统设计的新思路,具有易实现,应用广的特点。As one of the most sought-after mobile application terminal operating; system, Android has become an indispensable part of the intelligent; application system, because it has the features of definite openness,; flexibility for development, perfect connection with Google applications; and abundant third party software and hardware resources and so on.; Arduino MCU system is widely used in society because of its; characteristics of open source electronic prototype platform, flexible; and convenient design, rich sensor resources, etc. Moreover, its classes; Java and C language based on Wiring/Processing development environment; are becoming more and more popular among the electronics enthusiasts and; developers. Taking the mobile phone Android system as wireless control; terminal, and combining Arduino MCU system, an intelligent home control; system based on Android and Arduino is designed and implemented in this; paper. By controlling LED lamp samples, with the network HTTP; transmission control instructions sending to the Arduino MCU system, and; according to the received instructions, Arduino can control different; household electrical appliances to complete the required tasks.; Experiments show that the methods designed in this paper can be flexibly; applied to daily household appliances, such as, home appliance control,; security equipment, etc. This paper provides a new idea for the design; of intelligent home system, which is easy to implement and widely used.2015年度"福建省高校杰出青年科研人才培育计划"项目; 2015年福建省高等学校创新创业教育改革项目;; 2016年本科高校重大教育教学改革研究项目; 2016年省级互联网实验教学示范中心项目; 2016年福建省高等学校服务产业特色专业建设项

Metal Oxide Application on Thin Film Solar Cells

太阳能电池是解决能源衰竭和环境污染问题的有效途径之一。在太阳能电池薄膜化发展过程中,金属氧化物因为工艺简单、清洁环保及优良的能带结构成为极具潜力的光伏材料,广泛用于制作各种结构薄膜电池。本文从结构、制备工艺及光电转换效率等方面综述了TI O2、zn O及铜氧化物材料在薄膜太阳能电池的应用研究现状,讨论了各种材料光伏性能的影响因素,并分析了各自的发展趋势及应用前景。Solar cells provide a feasible way to relieve energy crisis and prevent the environment pollution.In the process of developing thin film solar cells,metal oxides are proved as one of the most promising photovoltaic materials due to the simple processing technology,clean,green and the desired band- gap,and they have been widely used on different kinds of thin film solar cells.The research on current application of Ti O2,Zn O and Cux O were introduced from structure,preparation and conversion efficiency of the cell,and the influence factors on photovoltaic property,the future developments and potential applications of each materials were discussed.国家自然科学基金(批准号:61203176); 福建省自然科学基金(批准号:2011J05154;2013J05098

Biological mechanism underlying the formation of greasy fur

腻苔是一种临床常见的病理性舌苔,主湿浊、痰饮、食积等,在中医临床诊断与治疗中有重要的临床意义与辨证价值,研究腻苔形成的现代生物学机制有重要的理论; 和实践意义。文章从舌表面脱落细胞学、微生态学、相关蛋白与基因表达及物质代谢等方面对腻苔形成的生物学机制进行了综述,并对腻苔与肠道微生态的关系,腻; 苔与现代医学疾病的关系进行了阐述,以期从现代生物医学角度对腻苔形成的物质基础、发生机制、变化规律及与相关疾病的关系作相关阐明,为疾病的中医诊断与; 治疗提供借鉴和帮助。Greasy fur is a common pathological tongue coating and is mainly seen in; the clinical practice in traditional Chinese medicine (TCM), such as in; the dampness turbidity, the phlegm and fluid retention, the dyspepsia or; food accumulation, and so on. Greasy fur shows important clinical; significance and differentiation value in TCM diagnosis and treatment,; there is also great theoretical and practical significance in the; studying of the modern biomedical mechanism underlying the formation of; the greasy fur. Here we summarized the formation mechanism of the greasy; fur from the aspects of the shedding cytology of the tongue surface, the; microecology, the expression of the relative genes and proteins and the; metabolism. The relationship between the greasy fur and the intestinal; microecology, and between the greasy fur and the diseases were also; discussed in this paper. Through summarizing these related research; literatures, we want to elucidate the material basis, the occurrence; mechanism and the changing rules of the greasy fur from the perspective; of the modern biomedicine, and to elucidate its relationship with some; related modern medicine diseases, thus to provide references and; assistance for the disease diagnosis and treatment in TCM clinic.国家重点研发计划重点专项; 教育部新世纪优秀人才支持计划; 国家自然科学基金项

Study of the Interaction of Disubstituted Cucurbit[6]uril with 2-(Aminomethyl)pyridine

分别用核磁共振、紫外可见吸收和X射线单晶衍射方法研究对称四甲基六元瓜环与2-氨基甲基吡啶的相互作用及其结构特征.1HNMR谱图和紫外可见吸收光谱图清晰表明,2-氨基甲基吡啶与对称四甲基六元瓜环有明显的相互作用,客体2-氨基甲基吡啶的吡啶环部分进入了瓜环空腔,1HNMR谱图相关质子峰的积分强度以及客体吸光度随主体瓜环浓度变化明确表示它们之间形成了1∶1的包结配合物,此包结比并不随瓜环的浓度增加而改变.X射线单晶衍射法对包结配合物晶体的测定进一步证实了核磁共振、紫外可见吸收方法所得结论.Interaction and structure of a host-guest inclusion complex of symmetrical tetramethyl substi- tuted cucurbit[6]uril (TMeQ[6]) with 2-(aminomethyl)pyridine (amp) have been studied by using 1H NMR technique, UV-visible spectrophotometry and single crystal X-ray diffraction determination. The experimen- tal results from 1H NMR and UV-visible spectra revealed that the amp as a guest enters into the cavity of TMeQ[6] to form a host-guest inclusion complex of TMeQ[6] and amp with a constant ratio of 1∶1. The single crystal X-ray diffraction determination further confirmed the conclusions.国家自然科学基金(Nos.200261002,20362003);; 科技部国际科技合作重点计划(No.2003DF000030);; 贵州省省长资金;; 贵州省教育厅自然科学研究资助项目

无箍效应时不同桩核材料修复上颌中切牙的体外实验

【目的】比较无箍效应时不同桩核材料修复上颌中切牙的抗折强度和断裂模式, 揭示不同修复方 式的修复效果。【方法】选择牙体完整的离体上颌中切牙48 颗, 截冠后随机分成4 组, 分别进行铸造不锈钢桩 核、铸造不锈钢桩树脂核、铸造纯钛桩核、铸造纯钛桩树脂核恢复桩核部分, 最后均行铸造不锈钢全冠修复。所 有实验模型在万能测试机进行力学加载, 记录抗折强度和断裂模式。【结果】除损坏废弃者, 余42 颗牙完成实 验。铸造不锈钢桩核抗折强度( 292±156) N 显著高于铸造纯钛桩核( 159±57) N; 明显低于铸造不锈钢桩树脂核 ( 440±90) N;与纯钛桩树脂核( 294±98) N 没有统计学差别。铸造不锈钢桩核和不锈钢桩树脂核都倾向于牙根垂 直折裂和脱位, 铸造纯钛桩核和纯钛桩树脂核倾向于根颈斜折。【结论】在本实验条件下, 修复体抗折强度与桩 核材料均有关, 修复体的断裂模式与桩材料有关, 树脂核有缓冲作用