老年人备灾现状及应对策略的研究进展

阐述国内外老年人的备灾现状,老年人应对灾害能力下降,备灾能力较低,应对灾害相关知识和教育缺乏,慢性疾病影响其备灾状态,其获取备灾信息途径和方式单一。提出需建立社区备灾组织、提供..

6-氨基青霉烷酸在弱碱性阴离子树脂IRA67上的吸附研究

用静态法研究了6-氨基青霉烷酸在弱碱性阴离子交换树脂IRA67上的吸附行为。在溶液pH为8.0,6-APA起始浓度介于3.00mg/ml~20.00mg/ml条件下,测定了25℃时IRA67树脂的静态交换动力学曲线、吸附等温线,并求得了IRA67树脂的平衡速率常数及吸附等温线方程。分别用Langmuir型和Frendlich型方程对IRA67树脂吸附等温线进行线性回归拟合,结果表明,6-APA在IRA67树脂上的吸附更符合Langmuir型吸附

NIJL News No.66 WINTER 2025

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Efficient solutions for bioinformatics applications using GPUs

Over the past few years, DNA sequencing technology has been advancing at such a fast pace that computer hardware and software can hardly meet the ever-increasing demand for sequence analysis. A natural approach to boost analysis efficiency is parallelization, which divides the problem into smaller ones that are to be solved simultaneously on multiple execution units. Common architectures such as multi-core CPUs and clusters can increase the throughput to some extent, but the hardware setup and maintenance costs are prohibitive. Fortunately, the newly emerged general-purpose GPU programming paradigm gives us a low-cost alternative for parallelization. This thesis presents GPU-accelerated algorithms for several problems in bioinformatics, along with implementations to demonstrate their power in handling enormous totally different limitations and optimization techniques than the CPU. The first tool presented is SOAP3-dp, which is a DNA short-read aligner highly optimized for speed. Prior to SOAP3-DP, the fastest short-read aligner was its predecessor SOAP2, which was capable of aligning 1 million 100-bp reads in 5 minutes. SOAP3-dp beats this record by aligning the same volume in only 10 seconds. The key to unlocking this unprecedented speed is the revamped BWT engine underlying SOAP3-dp. All data structures and associated operations have been tailor made for the GPU to achieve optimized performance. Experiments show that SOAP3-dp not only excels in speed, but also outperforms other aligners in both alignment sensitivity and accuracy. The next tools are for constructing data structures, namely Burrows-Wheeler transform (BWT) and de Bruijn graphs (DBGs), to facilitate genome assembly of short reads, especially large metagenomics data. The BWT index for a set of short reads has recently found its use in string-graph assemblers [44], as it provides a succinct way of representing huge string graphs which would otherwise exceed the main memory limit. Constructing the BWT index for a million reads is by itself not an easy task, let alone optimize for the GPU. Another class of assemblers, the DBG-based assemblers, also faces the same problem. This thesis presents construction algorithms for both the BWT and DBGs in a succinct form. In our experiments, we constructed the succinct DBG for a metagenomics data set with over 200 gigabases in 3 hours, and the resulting DBG only consumed 31.2 GB of memory. We also constructed the BWT index for 10 million 100-bp reads in 40 minutes using 4 quad-core machines. Lastly, we introduce a SNP detection tool, iSNPcall, which detects SNPs from a set of reads. Given a set of user-supplied annotated SNPs, iSNPcall focuses only on alignments covering these SNPs, which greatly accelerates the detection of SNPs at the prescribed loci. The annotated SNPs also helps us distinguish sequencing errors from authentic SNPs alleles easily. This is in contrast to the traditional de novo method which aligns reads onto the reference genome and then filters inauthentic mismatches according to some probabilities. After comparing on several applications, iSNPcall was found to give a higher accuracy than the de novo method, especially for samples with low coverage.published_or_final_versionComputer ScienceDoctoralDoctor of Philosoph

一种燃料推进剂全自动混合配制机构

本发明公开了一种燃料推进剂全自动混合配制机构,包括外部机构、内部机构、以及下位机控制系统,该外部机构包括机构结构箱体,布设在箱体顶部的箱体密封盖,依次布设在箱体各个侧面的排气管道、排气净化处理模块、电箱、不锈钢电动阀门、以及冷暖气输送管、空调外机；布设在箱体底部的机构脚轮；该内部机构设有多个用不锈钢夹芯板隔开的物理分区：依次为原料存储区域、试剂混合区域、成品存储区域、全自动电位滴定检测区域；所述原料存储区域设有多组原料储存罐、流量可控蠕动泵；本发明可在无人值守条件下进行相关液体混合推进剂的批量生产,精度控制系统将普通自动化生产线离不开的人工操作环节改造为全自动电位滴定仪采集,实现了闭环控制

胰岛素启动子因子1 基因P239Q突变与中国汉族人2 型糖尿病易感性的关系

【目的】了解胰岛素启动子因子1 基因P239Q 突变在中国汉族人中的分布情况, 以探讨其在2 型糖尿病的发生 发展中的作用。【方法】用PCR-RFLP 对233 例2 型糖尿病患者及89 例非糖尿病健康志愿者进行该点突变的筛查, 对检出阳 性者进行家系调查。【结果】病人组中仅发现1 例突变基因携带者, 对照组均为阴性, 家系研究显示该点突变不与糖尿病共分 离。【结论】该点突变在中国汉族人(包括2 型糖尿病患者)中相当少见。该突变不与糖尿病共分离, 且在非糖尿病者中亦可 被检出, 推测其可能作为一种修饰基因, 与其它位点的突变共同作用, 促进糖尿病发生