Synthesis of 1-(4-(n-heptoxy) butyl) hexahydro-2H-azepin-2-one

1-（4-正庚氧基）丁基己内酰胺1可由正庚醇与1，4-二卤代丁烷反应后，再与己内酰胺反应制得。每步均在混合无机碱kOH/k2CO3（作为碱性试剂）和季铵盐（作为固-液相转移催化剂）存在下进行反应。This paper reports the sequential reactions of nheptyl alcohol with 1,4-dihalobutane, and then with 4-caprolactam in two steps of solid-liquid phase transFer catalytic reaction to the title compound 1

新透皮吸收促进剂D_6与Azone对比研究

新透皮吸收促进剂d_6与AzOnE对比研究厦门大学抗癌研究中心林兴舜，李忌厦门大学化学系周瑞仪，李伟杰d6等系列化合物为新合成的透皮吸收促进剂（助渗剂），为氨基的醇衍生物，其结构已有红外光谱（Ir）、核磁共振（HnMr）、元素分析所确证，并已登记专利..

SYNTHEESIS of CHLOROACETIC ESTER BY THE METHOD of CALCIUM OXIDE DEHYDRATION

报道了一种以氯乙酸和脂肪醇为原料合成氯乙酸酯的新方法,即在催化剂作用下,用氧化钙作脱水剂,采用索氏提取器进行回流脱水直接酯化。应用该方法,酯化反应时间仅需2~3H,产率高达93%~98%,同时对影响产率诸因素进行考察,确定了最佳反应条件This paper describes a new method of synthesis of chloroacetic ester From chloroacetic acid and Fatty alcohol, and the experiment is carried out by the action of catalytic agent, the dehydration of calcium oxide and the direct esteriFication using Soxhelt extraction apparatus.In this method, only 2～3 h of the reaction time iF the esteriFication are needed, and the yield is up to 93%～98%.The eFFects of varrious Factors on the reaction yields are examined and the best reaction conditions are Found out

JUNO Sensitivity on Proton Decay p→νˉK+p\to \bar\nu K^+ Searches

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this paper, the potential on searching for proton decay in $p\to \bar\nu K^+$ mode with JUNO is investigated.The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits to suppress the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar\nu K^+$ is 36.9% with a background level of 0.2 events after 10 years of data taking. The estimated sensitivity based on 200 kton-years exposure is $9.6 \times 10^{33}$ years, competitive with the current best limits on the proton lifetime in this channel

JUNO sensitivity on proton decay p → ν K + searches*

The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the $p\to \bar{\nu} K^+$ mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via $p\to \bar{\nu} K^+$ is 36.9% ± 4.9% with a background level of $0.2\pm 0.05({\rm syst})\pm$$0.2({\rm stat})$ events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is $9.6 \times 10^{33}$ years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies