Synthesis of 1-(4-(n-heptoxy) butyl) hexahydro-2H-azepin-2-one

Abstract

1-（4-正庚氧基）丁基己内酰胺1可由正庚醇与1，4-二卤代丁烷反应后，再与己内酰胺反应制得。每步均在混合无机碱kOH/k2CO3（作为碱性试剂）和季铵盐（作为固-液相转移催化剂）存在下进行反应。This paper reports the sequential reactions of nheptyl alcohol with 1,4-dihalobutane, and then with 4-caprolactam in two steps of solid-liquid phase transFer catalytic reaction to the title compound 1