390 research outputs found

    Molecular mechanism of inhibitory effect of aspirin-triggered lipoxin A4 on endometriosis

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    子宫内膜异位症(Endometriosis,EM)是育龄妇女的常见病、难治病。它是指具有活性的子宫内膜出现在子宫腔以外所引起的一种病变。目前,EM发病机制尚不清楚,但是其作为一种雌激素依赖性疾病和炎症性疾病的观点已得到人们的普遍接受。近年来,作为内源性炎症反应“刹车信号”的脂氧素已被证实在炎症反应和雌激素信号途径中发挥着重要调节作用。虽然已有研究显示脂氧素可以抑制EM的发展,但是关于脂氧素在EM中的分子作用机理仍知之甚少。 本论文首先比较分析了EM患者和正常人中脂氧素受体ALXR的表达差异,证实脂氧素与内异症间存在联系。RT-PCR和免疫组织化学的结果表明,EM患者异位子宫内膜组织中ALXR...Endometriosis (EM) is a common and refractory gynaecological disease. It is defined as defined as the presence of endometrial tissue outside of the uterus. Despite the fact that the underlying mechanisms responsible for EM remain unclear, EM has been widely accepted as an oestrogen-dependent and inflammation-related disorder. Recently, lipoxins, the endogenous “breaking signals” in inflammation, h...学位:理学博士院系专业:生命科学学院生物化学与生物技术系_生物化学与分子生物学学号:2172009015356

    Optimal Reinsurance Contract with the Mix Use ofIndexed Catastrophe Bond

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    20世纪90年代出现的保险风险证券化,被国际保险业视为保险在资本市场上的一个重大金融创新,是巨灾风险分散的另一新兴工具。本文旨在分析保险风险证券化的重要产品之一----指数巨灾债券(IndexedCatastropheBonds),与传统的再保险间的相互关系。一旦巨灾发生,再保险合同面临的最大问题是存在违约风险,而指数巨灾债券的设计则有效地避免了违约风险,但由于其赔付触发条件是一个与原保险人实际损失相关的随机变量,如:行业损失水平或地震震级等,而非按原保险人实际损失进行赔偿,因此存在基差风险;同时,由于原、再保险人的信息不对称,双方对再保险合同的违约风险存在认知差异。因此,当原保险人同时运用指...ABSTRACT Insurance-linked securities,emerging at the beginning of 1990s, are shown as an important financial innovation that shifting catastrophe risk from insurance markets to financial markets. In this paper, we aim to analyze the interaction between reinsurance and Indexed Catastrophe Bonds ( ICB ), the main kind of insurance-linked securities, in catastrophe risk management. A major problem...学位:经济学博士院系专业:经济学院金融系_金融学(含保险学)学号:B20011203

    啦啦队的音乐和动作的选编初探

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    采用文献资料法、调查访问法和观察分析法,对啦啦队的音乐和动作的选编进行了较为深入的探讨,得出的结论为:(1)充分把握啦啦队的动作特点是创编的基本方向;(2)掌握竞赛规则是音乐和动作创编的主要依据;(3)动作的直接表现者是音乐和动作创编的制约因素;(4)外在的环境因素是音乐和动作创编的影响因素

    "Tao" and "Etiquette" in Western Hunan Tujia Villages

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    本文以土家族传统聚落——劳庄为例,通过分析与论述道家思想对湘西土家族聚落选址与格局、整体功能布局、建筑环境和建筑空间以及建筑材料等方面的影响;阐述了在道家思想下的湘西土家族传统聚落格局特征,进而为当代居住区的规划设计、空间建设、建筑节能设计提供了一定的启示与借鉴。This text with Tujia's people traditional settlement-Laozhuang for example,pass analysis and discuss Taoist thought to choose address and structure and form to the Tujia's people traditional settlement of the wese of Hunan,whole function layout,building environment and building space and building material etc.of influence;Elaborated to thought a next traditional settlement characteristic of Tujia's people traditional settlement of the wese of Hunan at Taoist,then design for the programming of contemporary small area,space construction,constructed an economy energy design to provide certain of apocalypse with draw lessons from

    Symbiosis of Culture and Geographical——The Minnan Rhymes Cultural Center Program Design as an Example

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    本文以厦门闽南童谣文化中心方案为例,通过介绍该方案在传承闽南文脉、优化具体功能要求和控制轴线关系等方面的设计思考,以及在构造细节、材料方面的关注,旨在研究批判的地域主义在当代建筑多元发展的形势下,如何结合传统地域文化特色,对稍显冷漠的现代主义进行修正和回应,进而对文化中心类型的建筑如何运用批判的地域主义思想,将现代空间与传统文化的结合进行有益的探索。Taking "Xiamen Minnan Tongyao Culture Center" project as an example, through introducing the scheme's design concept in inheriting minnan context, optimizing the specific functional requirements and controlling axis relations, and the attention of the detail constructions and material aspects, thus to discuss how to use Critical Regionalism to combine traditionalregional culture characteristics in the diversified situation of development, to modify and response to the slightly aloof modernism.Further more, we can carry on the beneficial exploration of how to apply the idea of critical regionalism to modern space as well as traditional culture to cultural buildings

    “走出去”战略中存在的人力资源管理问题和对策

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    本文分析了中国对外直接投资的人力资源战略存在的问题,并探讨了跨国经营的人力资源管理对策。本文认为:中国企业要实现“走出去”的发展战略,在人力资源管理上,要加强以“以人为本”的企业文化建设,并将其贯穿于人才招聘、选拔、培训、考核评价等环节中;在人才选拔战略上,应强调人才的基本素质及其工作经验与业绩;薪酬设计要尽量提高科学性和规范性,要推广股票期权激励机制;应提高对跨国企业人力资源管理队伍的素质,健全人力资源管理的职能

    日本私立高等教育的经费与管理政策

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    在日本高等教育的结构体系中,私立高等教育占有非常重要的地位,究其主要原因是由于多样化的政策。其中,立法政策主要为私立高等教育发展提供了法律保障;经费政策为私立高等教育扩展和质量的提高提供了有力的经济支撑;管理政策为规范私立高等教育的运营奠定了基础。辽宁省“十一五”教育科学规划课题“中、美、日私立高等教育政策比较研究”([高78])的阶段性成

    Self-Perceived Attractiveness and Its Influence on the Halo Effect and the Similar-to Me Effect

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    The present research examined the influences of the halo effect and the similar-tome effect on physical and sexual attractiveness for hiring decisions. It was hypothesized that the halo effect would cause applicants rated highly in physical and sexual attractiveness to receive higher ratings of hireability than unattractive applicants.However, if the similar-to-me effect is influential for levels of attractiveness in hiring situations, participants who rated themselves as less attractive should favor unattractive applicants. The results did not show an interaction between participant self-ratings and ratings of hireability, indicating the similar-to-me effect does not apply to physical or sexual attractiveness. There was a main effect of sexual attractiveness of the applicant forhireability, showing support for the halo effect. This effect was only found for White applicants, potentially due to in-group bias and out-group homogeneity

    玻璃化冷冻和程序化冷冻方法对人类卵母细胞骨架及其发育潜能的影响

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    目的探讨玻璃化冷冻和程序化冷冻对人卵母细胞纺锤体定位、细胞骨架及其发育潜能的影响。方法将第2日发育为M_II卵母细胞随机分为对照组、程序化冻融组、玻璃化冻融组(解冻0 h、1 h、3 h)。应用液晶偏振光显微镜(Polscope)成像系统观察卵母细胞纺锤体与第一极体(Pb)的夹角、表面积、卵透明带内层光阻值和外层光阻值。采用扫描电子显微镜和透射电子显微镜观察卵母细胞的表面和内部超微结构。统计2种冻融方法对卵母细胞发育潜能的影响。结果对照组、程序化冷冻解冻培养3 h组和玻璃化冷冻解冻后培养0 h、1 h、3 h组中的纺锤体可见率分别为92.4%、56.4%、11.2%、24.8%、61.1%。与程序化冻融组相比,玻璃化冷冻解冻培养3 h后卵母细胞中纺锤体与Pb的夹角更小(37.3°与68°,P=0.023)。对照组、程序化冻融组和玻璃化冻融后培养3 h组中卵母细胞的纺锤体面积、卵透明带内层光阻值和透明带外层光阻值差异无统计学意义(P>0.05)。与程序化冻融组相比,玻璃化冻融后培养3 h组中卵母细胞表面突起丰富,微绒毛形态较为正常,倒伏在细胞表面,卵透明带边界较为清晰,与对照组较为接近。程序化冻融组的正常受精率(65.7%)明显低于对照组(79.2%,P=0.041),而卵裂率和囊胚形成率与对照组和玻璃化冻融组差异无统计学意义(P>0.05)。玻璃化冻融后培养3 h组中正常受精率、卵裂率、囊胚形成率与对照组相比,差异无统计学意义(P>0.05)。结论相比程序化冷冻,玻璃化冷冻对卵母细胞纺锤体和卵透明带的损伤及对卵母细胞的发育潜能的影响都较小,可以作为卵母细胞冷冻的一种有效方法。国家自然科学青年基金(81701419);;国家自然科学基金面上项目(81571418)~

    空间·事件·漫游

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    研究空间、事件和漫游的关系,旨在研究构建氛围和事件对建筑的活力的影响。本文通过梳理关于"空间与知觉"的探索脉络,追溯了屈米、库哈斯等建筑师的理论根源。从艺术家对"空间与主观感知"的探索,到建筑流派对"空间与事件之间相互依存"的声明,发展到部分"用激发事件可能性来塑造空间"的解构主义手法,这一系列探索承前启后,都是针对现代主义理性控制的反抗和回应,也是事件空间作为主观倾向设计思路开始崭露头角的一方面历程
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