Core-shell Hydroxyapatite Combined with Bone Morphogenetic Protein 2 in Periodontal Regeneration Treatment in Dogs

目的初步评估贝壳多孔羟基磷灰石基骨修复材料及该材料和骨形成蛋白-2联合应用引导比格犬牙周组织再生的效果。方法选取18月龄比格犬6只,牙周基础治疗后1周,在下颌第二、三、四前磨牙,建立急性牙周骨缺损模型,依照分组情况进行不同治疗。实验组(T组)植入骨修复材料和骨形成蛋白-2;阴性对照组(nC组)植入骨修复材料;空白对照组(bC组)不植入任何材料。实验设计采取同颌同名牙对照,同一只比格犬的3对同颌同名牙分别为:空白对照组和阴性对照组,阴性对照组和实验组,空白对照组和实验组。术后12周,处死动物,MICrO-CT检查并对数据进行统计学分析。结果材料植入后,未见材料溢出,植入局部和全身都未见明显不良反应。3组缺损都有一定程度骨再生,以T组再生组织量最多,bC组最少。MICrO-CT结果显示:T组、nC组和bC组的骨再生平均高度为(4.50±0.47)MM(、1.75±0.42)MM和(0.87±0.31)MM。nC组和bC组相比,差异有统计学意义(P<0.05)。T组与nC组和bC组相比,差异均有统计学意义(P<0.05),且有临床意义。结论贝壳多孔羟基磷灰石基骨修复材料和骨形成蛋白-2联合应用于比格犬,可以获得更好的引导组织再生效果。Objective To evaluate the ability of core-shell hydroxyapatite bone graft material alone and combined with bone morphogenetic protein 2(BMP-2) in periodontal regeneration treatment in dogs.Methods Thirty-six defects were created in six 18-months male beagle dogs at the sites of the second,third and fourth mandibular premolars one week later after the dogs were treated with non-surgical periodontal therapy.Different treatments were carried out according to which group the teeth belonged.There are 3 groups.The test group(group T) was treated with core-shell hydroxyapatite bone graft material combined with BMP-2;the negative control group(group NC) was treated with core-shell hydroxyapatite bone graft material alone and the blank control group(group BC) was treated with no graft material.When a tooth was selected into one of the 3 groups randomly,the tooth with the same name on the other side in the same jaw was selected into another group.6 defects in the same dog were made and divided into 3 groups.The animals were sacrificed 12 weeks after surgery and analyzed by Micro-CT.Results There was no adverse reaction after material was planted.There were bone regenerations in all groups.Group T got the best bone regeneration while group BC got the least bone regeneration.The biggest height of bone regeneration for group T,group NC and group BC were(4.50±0.47) mm、(1.75±(0.42) mm) and(0.87±0.31) mm according to Micro-CT evaluation.There were statistical difference of bone regeneration height between group NC and group BC.There were statistical differences between group T and group NC and between group T and group BC.Conclusion More periodontal tissue regeneration could be got when core-shell hydroxyapatite bone graft material was used with bone morphology protein 2.南京市医学科学技术发展专项项目(ZKX07022);天津市生物医学材料重点实验室开放课题;南京市医学科技发展青年人才启动项目(QYK10166

类泛素蛋白及其中文命名

泛素家族包括泛素及类泛素蛋白,约20种成员蛋白.近年来,泛素家族领域取得了迅猛发展,并已与生物学及医学研究的各个领域相互交叉.泛素家族介导的蛋白质降解和细胞自噬机制的发现分别于2004和2016年获得诺贝尔奖.但是,类泛素蛋白并没有统一规范的中文译名. 2018年4月9日在苏州召开的《泛素家族介导的蛋白质降解和细胞自噬》专著的编委会上,部分作者讨论了类泛素蛋白的中文命名问题,并在随后的\"泛素家族、自噬与疾病\"(Ubiquitinfamily,autophagy anddiseases)苏州会议上提出了类泛素蛋白中文翻译草案,此草案在参加该会议的国内学者及海外华人学者间取得了高度共识.冷泉港亚洲\"泛素家族、自噬与疾病\"苏州会议是由美国冷泉港实验室主办、两年一度、面向全球的英文会议.该会议在海内外华人学者中具有广泛影响,因此,参会华人学者的意见具有一定的代表性.本文介绍了10个类别的类泛素蛋白的中文命名,系统总结了它们的结构特点,并比较了参与各种类泛素化修饰的酶和它们的生物学功能.文章由45名从事该领域研究的专家合作撰写,其中包括中国工程院院士1名,相关学者4名,长江学者3名,国家杰出青年科学基金获得者18名和美国知名高校华人教授4名.他们绝大多数是参加编写即将由科学出版社出版的专著《泛素家族介导的蛋白质降解和细胞自噬》的专家

The Research of the Last Kilometer Logistics on O2O Business Model

新经济时代的不断发展，使得企业的战略中心逐渐聚焦为“以客户为核心”，一种新的商业模式O2O（OnlinetoOffline）浮现，将线上虚拟经济和线下实体店全面融合起来,让在线支付、现实就近消费成为可能。也随着互联网的快速发展，电子商务从B2B、B2C、C2C正迈向O2O模式。与B2C和C2C模式相比，O2O模式给到顾客极大的便捷，表现出相对成交率高、信任度好的特点。 由于物流的发展跟不上电子商务的发展，所以电子商务要不断革新面临的最大问题是如何加快物流发展速度，完善配送体系。最后一公里物流是客户对网上购物和品牌满意度影响最大的关键点，因此如何提高最后一公里物流成为了新的电子商务模式发展最大...With the coming of new economic era, enterprise's strategic center is from "with products as the core" to "taking the customer as the core", can a comprehensive integration of Online virtual economy entity and Offline shop business model O2O (Online to Offline), make it possible for Online payment and realistic consumption nearby. With the rapid development of Internet, B2B, B2C, C2C e-commerce i...学位：工程硕士院系专业：管理学院_物流工程学号：1772011115112

the state-of-the-art of research on impossible differential cryptanalysis

不可能差分分析作为差分分析的一种变体,是一种简单有效的密码分析方法,也是目前最常用的密码分析方法之一.该方法一经提出就得到了广泛应用,被用于分析大量的算法和密码结构.尤其是近年来对AES的攻击,得到了一系列非常好的攻击结果,使得不可能差分分析已成为对AES最有效的攻击方法之一.系统介绍了不可能差分分析的原理、常用技巧和攻击方法,并总结了目前的研究现状和已取得的攻击结果.最后,分析了不可能差分攻击的优缺点及其在设计和分析分组密码方面的作用

rectangle and boomerang attacks on des

作为加密标准，DES（data encryption standard）算法虽然已被AES（advanced encryption standard）算法所取代，但其仍有着不可忽视的重要作用．在一些领域，尤其是金融领域，DES和Triple DES仍被广泛使用着．而近年来又提出了一些新的密码分析方法，其中，Rectangle攻击和Boomerang攻击已被证明是非常强大而有效的．因此，有必要重新评估DES算法抵抗这些新分析方法的能力．研究了DES算法针对Rectangle攻击和Boomerang攻击的安全性．利用DES各轮最优差分路径及其概率，分别得到了对12轮DES的Rectangle攻击和对11轮DES的Boomerang攻击．攻击结果分别为：利用Rectangle攻击可以攻击到12轮DES，数据复杂度为2~(62)。个选择明文，时间复杂度为2~(42)次12轮加密；利用Boomerang攻击可以攻击到11轮DES，数据复杂度为2~(58)个适应性选择明密文，时间复杂度为2~(38)次11轮加密．由于使用的都是DES各轮的最优差分路径，所以可以相信，该结果是Rectangle攻击和Boomerang攻击对DES所能达到的最好结果

differential fault analysis on sms4

SMS4是用于WAPI的分组密码算法,是国内官方公布的第一个商用密码算法.由于公布时间不长,关于它的安全性研究尚没有公开结果发表.该文研究SMS4密码算法对差分故障攻击的安全性.攻击采用面向字节的随机故障模型,并且结合了差分分析技术.该攻击方法理论上仅需要32个错误密文就可以完全恢复出SMS4的128比特种子密钥.因为实际中故障发生的字节位置是不可能完全平均的,所以实际攻击所需错误密文数将略大于理论值;文中的实验结果也验证了这一事实,恢复SMS4的128bit种子密钥平均大约需要47个错误密文.文章结果显示SMS4对差分故障攻击是脆弱的.为了避免这类攻击,建议用户对加密设备进行保护,阻止攻击者对其进行故障诱导

related-key impossible differential attacks on reduced-round aes-256

研究AES-256抵抗相关密钥-不可能差分密码分析的能力.首先给出相关密钥的差分,该差分可以扩展到8轮(甚至更多轮)子密钥差分;然后构造出一个5.5轮的相关密钥不可能差分特征.最后,给出一个对7轮AES-256的攻击和4个对8轮AES-256的攻击

differential fault analysis on hight

对HIGHT进行了差分故障攻击。攻击采用单字节级的差分故障模型,在倒数第3轮和倒数第4轮进行故障诱导来恢复密钥。模拟实验结果显示采用大约32次故 障诱导便可恢复密钥,分析的计算复杂度约为2~(56)。模加差分表预计算的复杂度为2~(32)。In this paper,we present differential fault analysis on HIGHT with a single byte fault model.We inject the fault at the third and fourth rounds from bottom.The 128-bit user key can be obtained by using 32 faulty ciphertexts with a computational complexity of 2~(56).The pre-computed complexity is 2~(32)

CBCR:采用循环移位的CBC MAC

在现代通信中,消息鉴别码广泛应用于数据的完整性保护和起源认证.文中提出一个基于分组密码的消息鉴别码算法CBCR,它在认证任意长度的消息时都具备可证明安全的保障.CBCR在密码分组链接模式的末端采用循环移位操作,并且对所有消息都加入一个定长的前缀,后者使得它在现实应用中具备一定的灵活性.比如说,这些定长的前缀可以是一些安全参数或消息冗余等.文中还给出CBCR0,它在CBCR中使用一个全0分组作为前缀.同美国国家标准技术研究所的一个推荐标准CMAC相比,CBCR0具备CMAC的所有优点,并且占用较少的内存.所以,在实际应用中,CBCR0的性能和CMAC相当,而且它更适用于智能卡等内存受限的环境

BAT评分联合CTA点征对幕上自发性脑出血患者早期血肿扩大的预测价值研究 The Predictive Value of BAT Score Combined with CTA Spot Sign for Hematoma Expansion in Patients with Spontaneous Supratentorial Intracerebral Hemorrhage

目的 研究BAT评分联合CTA点征对幕上自发性脑出血患者早期血肿扩大的预测价值。 方法 回顾性分析2021年9月—2022年4月连续于首都医科大学附属北京天坛医院急诊就诊且发病至一站式CT检查时间在6 h内的幕上自发性脑出血患者的资料，根据发病后24～48 h复查头颅CT与基线CT的血肿体积对比，分为血肿扩大组和非血肿扩大组。比较两组患者的基本临床资料、CTA点征及非增强CT（non-contrast computed tomography sign，NCCT）特点（低密度征、混合征等）影像资料、BAT评分（blend sign，any hypodensity，timing of NCCT score，BAT）。采用单因素分析和多因素logistic回归分析血肿扩大的危险因素，并绘制ROC曲线分析BAT评分、CTA点征及两者结合对自发性脑出血患者早期血肿扩大的预测价值。 结果 共纳入97例患者，血肿扩大组28例，非血肿扩大组69例。血肿扩大组患者CTA点征，NCCT低密度征、混合征的发生率均高于非血肿扩大组，BAT评分中位数和BAT评分≥3分的患者比例均高于非血肿扩大组，发病至基线影像时间短于非血肿扩大组，基线出血体积和基线随机血糖水平高于非血肿扩大组，上述差异均有统计学意义。多因素logistic回归分析结果显示，CTA点征阳性（OR 31.828，95%CI 5.350～189.337，P＜0.01）、BAT评分≥3分（OR 71.976，95%CI 5.391～960.899，P＜0.01）、基线出血体积（OR 1.029，95%CI 1.003～1.055，P＝0.03）和基线随机血糖（OR 1.355，95%CI 1.070～1.714，P＝0.01）可独立预测血肿扩大。ROC曲线分析显示，基线出血体积预测血肿扩大的AUC为0.762，BAT评分≥3分预测血肿扩大的AUC为0.716，CTA点征阳性预测血肿扩大的AUC为0.756，BAT评分≥3分联合CTA点征阳性预测血肿扩大的AUC为0.833。De Long检验提示两者联合预测效力优于单独预测效力（P＜0.05）。 结论 幕上自发性脑出血患者发病6 h内，BAT评分≥3分及CTA点征阳性都可有效预测血肿扩大，两者联合预测的效力更佳。 Abstract: Objective To study the predictive value of the blend sign, any hypodensity, timing of NCCT (BAT) score combined with CTA spot sign for early hematoma expansion (HE) in patients with spontaneous supratentorial intracerebral hemorrhage (sICH). Methods A retrospective analysis was conducted on sICH patients who were admitted to the emergency department of Beijing Tiantan Hospital, Capital Medical University from September 2021 to April 2022 with a time from onset to one-stop CT within 6 hours. The patients were divided into HE group and non-HE group based on the comparison of hematoma volume between baseline CT and the follow-up CT done within 24-48 hours after onset. The clinical characteristics, CTA spot sign, non-contrast computed tomography sign (NCCT) (including the hypodensity sign, blend sign, etc) , and BAT score were identified and compared between 2 groups. Univariate analysis and multivariate logistic regression analysis was used to analyze the risk factors affecting the HE, and receiver operating characteristic was drawn to analyze the predictive value of BAT score, CTA spot sign and their combination on hematoma expansion in patients with sICH. Results A total of 97 patients, including 28 in the HE group and 69 in the non-HE group. The incidence of CTA spot sign, NCCT hypodensity sign, and blend sign in patients with HE group was higher than that in non-HE group. The median BAT score and the proportion of patients with BAT score≥3 were higher than those in non-HE group. The time from onset to baseline imaging was shorter than that in non-HE group. Baseline hematoma volume and baseline random blood glucose levels were higher than those in non-HE group. The above differences were statistically significant. The results of multivariate logistic regression analysis showed that positive CTA spot sign (OR 31.828, 95% CI 5.350-189.337, P<0.01), BAT score≥3 (OR 71.976, 95%CI 5.391-96.899, P<0.01), baseline hematoma volume (OR 1.029, 95%CI 1.003-1.055, P=0.03), and baseline random blood glucose (OR 1.355, 95%CI 1.070-1.714, P=0.01) can independently predict hematoma enlargement. ROC analysis showed that the AUC of baseline hematoma volume predicting hematoma enlargement was 0.762, the AUC of BAT score≥3 predicting hematoma enlargement was 0.716, the AUC of CTA spot sign predicting hematoma enlargement was 0.756, and the AUC of BAT score≥3 combining with CTA spot sign predicting HE was 0.833. The De Long test suggests that the combined predictive power of the two is superior to the individuals (P<0.05). Conclusions Within 6 hours of onset, both a BAT score≥3 and CTA spot sign can independently predict HE in patients with sICH, and the combined prediction is more effective