中学校和歌学習指導でのWAKATONの活用

情感豊かな鑑賞文を書くためには,適切な感性語を潤沢に使用することが必要である.筆者らは,中学校国語科の和歌の学習に和歌感性データベースを導入し,感性語に触れる機会を与えることで,感性語の習得を深めることを考えた(以下,Wakaton学習法---Waka Kansei technology supported online learning method---と呼ぶ).Wakaton学習法では,和歌の解釈に関するSD法を用いたアンケートが用いられる.これにより,生徒は,和歌の意味,解説,表現技法等を学習するだけでなく,より多くの感性語を学習する機会が与えられることが期待できる.実際の授業を通しての実証実験により,Wakaton学習法の導入によって,従来の指導法と比較して,生徒が鑑賞文中で使用する感性語の数と種類がより増加し,より情感豊かな鑑賞文を書くようになることが認められた.さらに,鑑賞文における感性語の使われ方と教師による鑑賞文の評価の間に,強い相関があることが認められた

中学校和歌学習指導でのWAKATONの活用

情感豊かな鑑賞文を書くためには,適切な感性語を潤沢に使用することが必要である.筆者らは,中学校国語科の和歌の学習に和歌感性データベースを導入し,感性語に触れる機会を与えることで,感性語の習得を深めることを考えた(以下,Wakaton学習法---Waka Kansei technology supported online learning method---と呼ぶ).Wakaton学習法では,和歌の解釈に関するSD法を用いたアンケートが用いられる.これにより,生徒は,和歌の意味,解説,表現技法等を学習するだけでなく,より多くの感性語を学習する機会が与えられることが期待できる.実際の授業を通しての実証実験により,Wakaton学習法の導入によって,従来の指導法と比較して,生徒が鑑賞文中で使用する感性語の数と種類がより増加し,より情感豊かな鑑賞文を書くようになることが認められた.さらに,鑑賞文における感性語の使われ方と教師による鑑賞文の評価の間に,強い相関があることが認められた

A case of a complete paraplegic fathering a girl following artificial insemination after an intrathecal neostigmine injection

A case of a 32-year-old paraplegic male who fathered a girl following artificial insemination after an intrathecal neostigmine injection is described. The patient became a complete paraplegic after injury to the spinal cord caused by a traffic accident in 1971, resulting in ejaculatory disturbance. In June, 1984 the first intrathecal neostigmine injection was tried and 2.7 ml of semen was collected and offered to artificial insemination. However, the first to ninth attempt did not result in fertilization. The tenth attempt was made in March 7, 1986, and 3 ml of semen presenting 240 X 10(6) spermatozoa per ml with 5% of motile sperms was collected. This resulted in pregnancy, and the patient's wife delivered a healthy girl weighing 2552 g by cesarean section on November 19, 1986. This is the fourth case of a paraplegic who fathered a child following artificial insemination after an intrathecal neostigmine injection in the Japanese literature

4 合併症に大きな差のある2型糖尿病の1卵性双生児(第77回新潟内分泌代謝同好会)

departmental bulletin pape

Male infertility with chromosomal abnormalities. III. 46, XYq-

A deletion of the long arm of the Y chromosome (46, XYq-) was found in two cases with normal male habitus but with azoospermia. The first case was of a 28-year-old married man, an office worker, complaining of infertility. His height was 153 cm, weight 57 kg and distance of extended hand 152 cm. Both testes were 13 ml in size. The second case was a 32-year-old married man, a fireman, complaining of infertility. His height was 160 cm, weight 64 kg and distance of extended hand 161 cm. Both testes were 10 ml in size. In each case, the external genitalia showed a normal male type, but azoospermia was identified in semen analysis. The testicular biopsy specimens revealed spermatogenic arrest with thickening of basement membrane. Chromosomal analysis showed 46, XYq- karyotype. Basal serum levels of luteinizing hormone and follicle-stimulating hormone were slightly elevated and the serum testosterone level was within normal limits. Eight cases of 46, XYq- karyotype in the Japanese literature including our cases were reviewed

5 CPM を発症した長期コントロール不良の 1 型糖尿病(I. 一般演題)(第 76 回新潟内分泌代謝同好会)

departmental bulletin pape

Clinical evaluation of ceftizoxime in the treatment of complicated urinary tract infections

Ceftizoxime (CZX) was given clinically to 80 patients with urogenital tract infections, in which 34 cases of complicated UTI satisfied the criteria of the UTI committee. CZX was administered for at least five days at a daily dose of 1 to 4 g in two divided doses by intravenous drip infusion. The overall clinical efficacy of CZX in 34 cases of complicated UTI was 59%, estimated by the criteria of the UTI committee. The overall clinical efficacy rate according to group of infection was: 64% for the 11 patients in the 1st group, 56% for the 9 patients in the 2nd group, 100% for the 5 patients in the 3rd group, 50% for the 4 patients in the 4th group and 20% for the 5 patients in the 5th group. No serious side effects were observed in the clinical or laboratory findings except for slight elevation in GOT & GPT values in two cases (2.5%), which returned to normal after CZX treatment. It is therefore suggested that CZX is a clinically useful and safe drug in the treatment of complicated UTI

4 抗甲状腺抗体陽性の劇症型糖尿病の 1 例(I. 一般演題)(第 76 回新潟内分泌代謝同好会)

departmental bulletin pape

Observation results by the TAMA300 detector on gravitational wave bursts from stellar-core collapses

We present data-analysis schemes and results of observations with the TAMA300 gravitational-wave detector, targeting burst signals from stellar-core collapse events. In analyses for burst gravitational waves, the detection and fake-reduction schemes are different from well-investigated ones for a chirp-wave analysis, because precise waveform templates are not available. We used an excess-power filter for the extraction of gravitational-wave candidates, and developed two methods for the reduction of fake events caused by non-stationary noises of the detector. These analysis schemes were applied to real data from the TAMA300 interferometric gravitational wave detector. As a result, fake events were reduced by a factor of about 1000 in the best cases. The resultant event candidates were interpreted from an astronomical viewpoint. We set an upper limit of 2.2x10^3 events/sec on the burst gravitational-wave event rate in our Galaxy with a confidence level of 90%. This work sets a milestone and prospects on the search for burst gravitational waves, by establishing an analysis scheme for the observation data from an interferometric gravitational wave detector

核孔蛋白93在神经母细胞瘤患者中的表达及临床意义

目的基于基因表达数据库（GEO）筛选神经母细胞瘤（NB）诊断和预后相关的关键基因，探讨关键基因核孔蛋白93（NUP93）在NB患者组织中的表达及临床意义。方法从GEO数据库中获取NB基因芯片数据（GSE73517、GSE49710、GSE19274），筛选高风险组共同上调的差异表达基因（DEGs），结合R2基因组分析和可视化平台进一步分析在MYCN扩增组中共同上调的DEGs的预后价值，筛选出关键基因；最后通过免疫组织化学法（IHC）检测60例NB、25例神经节神经母细胞瘤（GNB）和26例神经节神经瘤（GN）组织中NUP93的表达水平。结果①筛选出25个高风险组共同上调的DEGs，其中10个在MYCN扩增组中高表达（P＜0.05），分别为SIVA1、NUP93、STIP1、LSM4、RAI14、MYOZ3、KNTC1、TNFRSF10B、TACC3、CEP152；生存分析显示，NUP93高表达患者总生存期显著缩短（HR=4.0，95%CI：3.0，5.3，P=1.80×10⁻³⁴）。②免疫组化结果显示，NUP93在NB组织中的表达水平高于GN和GNB（P＜0.001），且与高有丝分裂-核碎裂指数（MKI）（P=0.040）、低分化程度（P＜0.001）及MYCN表达（rs =0.793，P＜0.001）呈正相关。结论经筛选获得的关键基因NUP93的高表达与高MKI及分化程度低相关，并预示NB患儿的不良预后，可能通过调控MYCN促进肿瘤进展，有望成为NB诊断标志物及治疗靶点