Acceleration of the lower-thermospheric wind measured with a Fabry-Perot interferometer around substorm onsets at Tromsø, Norway

第3回極域科学シンポジウム/第36回極域宙空圏シンポジウム 11月26日（月）、27日（火） 国立極地研究所 2階ラウン

Multilingual home environment and specific language impairment: a case-control study in Chinese children

published_or_final_versionMedical SciencesMasterMaster of Medical Science

福建省工程图学学科发展研究报告

总结了福建省工程图学学科的科技研究与应用、现代图学科技普及与技能培训、图学教育改革和人才培养的发展现状与存在的问题,指明了所面临的机遇和挑战,提出了我省工程图学学科今后一段时间的主要发展目标、海西建设的重点发展领域和具体对策

Neutrophil and M2-polarized Macrophage Infiltration, Expression of IL-8 and Apoptosis in Mycoplasma hyopneumoniae Pneumonia in Swine

Citation: Nueangphuet P, Suwanruengsri M, Fuke N, Uemura R, Hirai T, Yamaguchi R. Neutrophil and M2-polarized Macrophage Infiltration, Expression of IL-8 and Apoptosis in Mycoplasma hyopneumoniae Pneumonia in Swine. J Comp Pathol. 2021 Nov;189:31-44. doi: 10.1016/j.jcpa.2021.09.004. Epub 2021 Oct 25. PMID: 34886984

Histopathological findings of the nasopharynx-associated lymphoid tissue of pigs co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus

Porcine circovirus 2 (PCV2) causes porcine circovirus-associated disease, and co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) severely affects the pig breeding industry. Both viruses target the macrophages in lymphoid tissues. Various porcine pathogens enter via the nasal cavity, and the nasopharynx-associated lymphoid tissue (NALT) acts as the mucosal immune system. However, the pathological analysis has not progressed. This study aimed to histologically examine the NALT of pigs with suspected PCV2 and PRRSV infections. Six pigs were subjected to necropsy, and their NALT, tonsils, and mesenteric lymph nodes were collected. Macrophages, lymphocytic depletion, multinucleated giant cells, intracytoplasmic inclusion bodies, and neutrophil infiltration increased in the NALT. In situ hybridization revealed positive signals for PCV2 in the NALT of all pigs and PRRSV in the NALT of three pigs. PCV2-positive macrophages were mainly identified in the follicles, whereas PRRSV-positive tissues were found primarily around the crypt and directly below the epithelium. Quantitative PCR revealed 108–1010 copies of PCV2 DNA/µL and 102–104 copies of PRRSV DNA/µL in the NALT. Therefore, both PCV2 and PRRSV were detected in the NALT of pigs. In conclusion, the infection and replication of both viruses in the NALT and tonsils may suppress host immunity and promote co-infection with other pathogens.Citation: Toyama K, Hirai T, Sueyoshi M, Zhou Z, Niazi AM, Kawaguchi N, Fuke N, Yamaguchi R. Histopathological findings of the nasopharynx-associated lymphoid tissue of pigs co-infected with porcine circovirus 2 and porcine reproductive and respiratory syndrome virus. J Vet Med Sci. 2022 Nov 14;84(11):1536-1542. doi: 10.1292/jvms.22-0231. Epub 2022 Oct 13. PMID: 36223944; PMCID: PMC9705823