Selective thrombosis in tumor vessels induced by fusion proteins huTNT-3/tTF and tTF-EG3287

选择性栓塞肿瘤组织血管从而诱发肿瘤组织的缺血性坏死是一种很有前景的抗肿瘤策略。该策略以截短的组织因子(truncatedTissueFactor，tTF)为效应因子，利用导向载体构建载体-tTF融合蛋白，将截断的组织因子tTF选择性靶向于肿瘤组织血管膜表面，可以诱发肿瘤组织血管栓塞，阻断肿瘤营养物质和氧气的供给，引发肿瘤缺血性坏死，发挥抗肿瘤作用。 为了验证融合蛋白tTF-EG3287选择性诱发肿瘤组织血管栓塞的活性，因而可以有效地靶向于肿瘤血管，导致血栓形成，我们利用PCR技术分别构建EG3287与tTF的融合基因，克隆基因至原核表达载体pET22b(＋)，通过优化其表达条件，实现目的蛋白...Selective thrombosis in tumor vessels and induction of subsequent tumor infarction is a promising anti-tumor strategy. This strategy use truncated Tissue Factor (tTF) as the effector, tTF(truncated tissue factor) is only the extracellular domain of tissue factor. When tTF is targeted to the tumor vasculature by the ligand of tTF fusion protein and contacts with the cell membrane closely, it could ...学位：医学硕士院系专业：医学院临床医学系_外科学学号：2452008115346

肿瘤血管靶向治疗策略的新进展

肿瘤血管生成(tumor angiogenesis)对大多数实体瘤的生长和转移具有重要意义,他是一个多步骤多因素参与的复杂病理过程.抗肿瘤血管的治疗策略分为抑制肿瘤新生血管生成和阻断肿瘤血管血流两方面.抑制肿瘤新生血管生成旨在抑制肿瘤新生血管生成的过程,目前研究的成果比较多;而阻断肿瘤血管血流则是通过快速而选择性地破坏肿瘤血管功能,使肿瘤血供受阻,对于治疗较大体积的肿瘤有显著的疗效.肿瘤血管的靶向治疗特别是阻断肿瘤血管血流将成为恶性肿瘤的一种新的、重要的常规治疗手段.本文对近年来这两方面的研究进展进行综述

小波分析及其在电力系统扰动检测中的应用

文章介绍了小波变换的基本原理和一种小波变换的快速算法——Mallat算法。在此基础上将其应用于电力系统中的电力信号的检测和故障诊断中,对故障信号进行分解与重构并用Matlab进行仿真。仿真结果表明:利用小波分析诊断电力系统的扰动信号非常的精确

Transplant of CDT Protocol to Traffic Monitoring Sys tem for Freeway

中文摘要：在解析了循环式远动规约( 即CDT 规约) 的基础上, 分别探讨了变电站系统与高速公路监控系统的系统体系结构与数据信息, 提出了电力远动通信协议在高速公路监控系统上的移植, 并拟定了高速公路监控系统通信协议的报文格式。英文摘要：Based on the analys is of CDT protocol,this paper discus ses the sys tem s tructure and the data information of the trans - former subs tation and the monitoring sys tem for freeway.Producing the transplanting of power telecontrol communication protocol to traffic monitoring sys tem for freeway.And drafting format of communication protocol of monitoring sys tem for freewa

Active H_∞ fault-tolerant control design and online optimal selection schemes of fault-tolerant controllers

本文设计了主动H∞容错控制器及其在线优化选择的多种容错控制策略,并且构造了“离线设计在线选择“容错控制模式下故障模式与容错控制器的多对多映射关系.首先,提出了针对给定故障模型的H∞容错控制器设计方法,离线设计了可恢复故障模式的容错控制器;其次,根据不同的需求,设计了3种方法缩小故障模式与容错控制器的所有可容错映射关系;然后,提出了4种主动容错控制器在线优化选择策略来满足不同的优化需求,提高容错控制性能;最后,仿真验证了所提出的主动H∞容错控制器及在线优化选择策略的有效性.This paper proposes an active H∞fault-tolerant control and optimal schemes for selecting a controller online, and constructs many-to-many mappings between fault modes and controllers under the "off-line design, online selection"fault-tolerant structure.According to the specific fault model, the active H∞fault-tolerant control is designed off-line for every recoverable fault mode.Then, three methods are presented to shrink all fault-tolerant mappings between fault modes and fault-tolerant controllers for different requirements.As a result, four selection schemes are proposed to choose a proper controller from a given set of controllers for a given fault mode.These four selections are designed for different requirements to improve the fault-tolerant performances of systems.Finally, a simulation is performed to illustrate and validate the effectiveness of the active H∞fault-tolerant controllers and the selection schemes.国家自然科学基金资助项目(61304110;61273162

Design and Analysis of Nonlinear H_∞ Guidance Law

针对导弹拦截目标制导过程中的测量噪声和干扰以及未知目标机动,本文提出了具有严格解析形式的三维非线性H∞导引律的设计方法。通过构建基于改进极坐标系下的三维弹目相对运动方程和存在多种测量噪声和干扰下的弹目相对运动方程,归纳推导出简洁的导弹拦截目标的系统方程;利用非线性H∞控制理论构造相应的HJI偏微分方程不等式,并且提出了HJI偏微分方程不等式的一种解法,得到了一组解析解,同时得到了拦截系统的一个正定储能函数,进而构造了非线性H∞导引律;通过分析非线性H∞导引律的设计方法和几项关键的制导拦截影响因素,定性指出了如何调整设计参数能够有效对抗各种不利因素,提高制导性能;最后,仿真研究验证了非线性H∞导引律的有效性和定性分析的有效性。An analytical three-dimensional nonlinear H∞guidance law is designed for coping with measurement noise and disturbance and unknown target maneuvering in the process of a missile intercepting an attacking target.By building a three-dimensional relative motion equation between the missile and the target in the modified polar coordinate and a relative motion equation between the missile and the target involving many types of measurement noise and disturbance,a simplified system equation of the missile intercepting the target is deduced.Then the corresponding HJI partial differential inequality is constructed by using nonlinear control theory.And then a solution method of HJI partial differential inequality is offered.Thus a set of analytical solutions and a positive definite storage function are obtained,and then the analytical three-dimensional nonlinear H∞guidance law is designed successfully.By analyzing the relationship of the design parameters of nonlinear H∞guidance law and several key interception factors of guidance,the analysis qualitatively points out that how to adjust design parameters can deal with a variety of adverse factors and improve guidance performance further more.Finally, simulation results verify the effectiveness of the proposed guidance law and the effectiveness of the qualitative analysis.国家自然科学青年基金(61304110;61301008); 航空科学基金(20140768003

Des ign for Communication of Data Center of GPRS DTU

中文摘要：介绍了基于 GPRS 网络的电力监控系统结构, 并根据 GPRS DTU 的特点, 结合网络编程的知识, 在 VC++6.0 平台上实现了 GPRS DTU 的数据中心的通信功能。英文摘要：This paper introduces the power monitoring and controling sys tem architecture,which is bas ed on GPRS,and according to the traits of GPRS DTU,combining the knowledge of network programming.This paper implements the functions of com- munication on data centers of GPRS DTUs on the platform of VC++6.0

抗菌药物对Hp感染胃溃疡患者血清胃蛋白酶原水平的影响

目的 探讨抗菌药物对幽门螺杆菌(Hp)感染胃溃疡患者血清中胃蛋白酶原水平的影响及治疗效果。方法选取厦门大学附属第一医院2015年10月—2016年9月收治并确诊Hp阳性胃溃疡患者86例,随机分为对照组(奥美拉唑治疗)和观察组(奥美拉唑和阿莫西林联合治疗),每组43例,比较两组治疗前后的血清胃蛋白酶原Ⅰ(PGⅠ)、PGⅡ水平,并观察两组的治疗效果。结果 两组治疗前的血清PGⅠ、PGⅡ水平比较,差异无统计学意义(P>0.05);治疗后两组患者的血清PGⅠ、PGⅡ水平明显下降,其中观察组PGⅠ、PGⅡ水平分别为(137.10±12.27)μg/L、(8.69±1.09)μg/L,明显低于对照组(P<0.05),同时观察组患者的治疗总有效率为95.35%,显著高于对照组的74.42%(P<0.05)。结论 抗菌药物治疗Hp感染胃溃疡患者具有更好的疗效,并可有效的降低血清中PGⅠ、PGⅡ的水平

翡翠贻贝足蛋白作为生物黏合剂的提取及应用

贻贝黏附蛋白作为一种潜在的环保性生物黏合剂,在医学以及水下应用等方面具有潜在价值。为了研究翡翠贻贝足部黏附蛋白(Pvfp)作为生物黏合剂的黏附特性,利用酸提取法提取Pvfp,并对其进行不同材料表面包被能力分析,以石英晶体微天平(QCM)检测蛋白在金表面的黏附量,分析该蛋白对细胞及组织的黏附能力以及细胞毒性。对不同材料表面包被能力以及QCM分析结果显示,Pvfp具有与Cell-TakTM相似甚至更佳的吸附能力;细胞黏附结果显示,Pvfp具有比Cell-TakTM和PLL(poly-L-lysine)更强的细胞黏附能力;对Hela细胞和293T细胞的毒性分析结果显示,Pvfp没有细胞毒性;组织黏附结果显示,Pvfp可以黏接断裂的小鼠股骨;黏接聚氯乙烯材料和黏接猪的断裂股骨实验结果表明,Pvfp具有比医用生物蛋白胶更强的抗张强度。提示,Pvfp蛋白可能作为有效的细胞和组织黏合剂而广泛应用于生物技术领域,并在临床应用生物黏合剂中具有潜在应用价值

Structure and Function of Marine Mussel Adhesive Proteins

海洋贻贝粘附蛋白具有高强度、高韧性和防水性,以及极强的黏附基体的功能,这与其特殊的分子结构、多巴(DOPA)介导的链间交联和与底材之间的相互作用方式有关,并且,它还具有很好的生物相容性和可降解性,是一类极具优势和潜力的生物胶黏剂.本文主要就粘附蛋白分子的结构和功能、粘附蛋白的粘附机理以及有关粘附蛋白生物粘剂等问题对其进行综述.The characteristics of marine mussel adhesive proteins,such as strong intensity, tenacity,moisture-resistance and strong adhesive ability,are due to their peculiarity of molecular structure, cross-linking of bonds and the interaction between proteins and substratum mediated by DOPA. Furthermore, they are biocompatible and biodegradable. Therefore, marine mussel adhesive proteins may be a preponderant and potential bio-adhesive. This review mainly focused on structure and function of adhesive protein molecule, adhesive mechanism of adhesive protein, and the potential of adhesive protein to be bio-adhesive.福建省青年科技人才创新项目(No.2004J022);; 国家自然科学基金(No.30600147)资助~