重量-压强法在大输液配制系统定容中的应用

目的建立医院大输液制剂配制系统定容方法。方法拟定纯化水体积与定容参数的相关性,测定输液的相对密度,计算配制量输液等同于同重量纯化水的体积,计算理论定容参数。结果采用重量-压强法能准确对医院大输液制剂配制系统进行定容。结论该方法操作简便,迅速,可用于大输液系统定容

全面深化改革导向的政府会计改革探索——第五届“政府会计改革理论与实务研讨会”综述

党的十八届三中全会通过的《中共中央关于全面深化改革若干重大问题的决定》(以下简称《决定》)中,多项决议都直接或间接地对中国的政府会计改革提出了需求,为开展政府会计改革理论研究和实践提供了很好的动力与导向。在此背景下,由中国会计学会政府及非营利组织会计专业委员会主办、厦门大学承办、厦门国家会计学院和厦门市财政局协办的第三届“公共管理、公共财政与政府会计跨学科论坛“暨第五届“政府会计改革理论与实务研讨会“于2014年5月10日至11日在厦门大学召开。与会者在政府会计准则制定、政府综合财务报告建设、政府会计改革的目标、路径、内容等若干方面达成了诸多共识

Mechanism of nanostructured lipid carriers in promotion of absorption of poorly soluble drugs

纳米结构脂质载体(nlC)是药剂学备受关注的研究领域,作为一种性能优良的新型药物传递系统,能促进难溶性药物的口服吸收。探讨并总结纳米结构脂质载体促进难溶性药物口服吸收的机制。Objective Nano-structured lipid carriers(NLC) is a concerned research area in pharmaceutics,which as a novel drug delivery system to promote oral absorption of poorly soluble drugs.The literatures were reviewed to explore and summarize the mechanism that nano-structured lipid carriers in promotion of the absorption of poorly soluble drugs

放疗与化疗所致口腔黏膜损伤防治药物研究进展

综述近年来防治放化疗所致口腔黏膜损伤的药物,拟为开发新制剂提供参考。通过检索国内外相关文献,从作用机制角度对防治药物进行归纳和总结。发现已有较多化学药物与传统中药复方应用于防治口腔黏膜损伤。因此,开发有效的防治放化疗所致口腔黏膜损伤制剂的相关研究需要进一步地深入

Progress on solid self-microemulsifying drug delivery system for oral administration

目的对新近发展的固体自微乳化给药系统(S-SMEddS)文献进行综述。方法查阅近年国内外相关文献并进行归纳和总结。结果对固体自微乳的载体、固化技术以及缓控释制剂进行了探讨,为研究水难溶性药物的生物利用度及适合药物释放特性的S-SMEddS技术提供相关参考。结论固体自微乳化系统可以显著提高难溶性药物的口服生物利用度,且兼顾了液态自微乳和固体制剂二者的优势,是一个极具潜力的新型制剂。Objective To review the newly developed solid self-microemulsifying drug delivery system(S-SMEDDS).Methods Relevant literatures at home and abroad in recent years were consulted and summarized.Results Solid self-microemulsions carrier,solidification technology and controlled release formulations were discussed,in order to provide relevant references for improving the bioavailability of water-insoluble drugs and the SMEDDS technology for drug release characteristics.Conclusion The utilization of the solid self-emulsifying drug delivery system could significantly enhance the oral bioavailability of water-insoluble drugs.As a new formulation,S-SMEDDS presented huge potential

Application of biomarkers in marine environment monitoring

总结了国内外近十几年可应用于海洋环境污染监测常见的生物标记物及其主要的检测方法,对各自的应用特点进行了阐述,并展望了其应用的前景。其中对DNA损伤的检测作了较为详细的介绍。This paper sums up the recent-year application of biomarkers in marine environment motoring and the main detection methods of them.The features and the future prospects of these biomarkers are also discussed. The introduction of the DNA damage is the most detailed part in this paper.国家自然科学基金资助项目(A20077023,C40106012

武夷山自然保护区生物多样性研究 1.小叶黄杨矮曲林物种多样性

本文为武夷山自然保护区生物多样性GEF项目内容之一 ,调查了保护区内不同海拔高度的代表性森林生态系统的物种多样性 .小叶黄杨 (Buxussinicavar .parvifolia)林是中山矮曲林的代表性类型之一 .应用Shannon Wiener多样性指数、Pielou均匀度、Simpson指数和PIE对武夷山小叶黄杨群落高等植物进行了物种多样性研究 .结果表明前两者是较好的多样性指标 ,该群落的Shannon Wiener指数值为 1.80 6 8,Pielou均匀度为 49.6 7% ,Simpson指数值为 2 .9146 ,PIE为 0 .6 5 6 9.群落乔木层与藤本植物的物种多样性较高 ,前者各项指数值分别为 2 .2 312 ,71.16 % ,5 .0 783,0 .80 31;后者各项指数值分别为 1.3371,83.0 8% ,3.5 32 7,0 .716 9

Preparation and biological safety of basic fibroblast growth factor/double-layered collagen composite

背景:胶原特殊的分子结构和生物活性有利于多种细胞黏附、增殖和分化,并可降解为新生组织提供足够空间。目的:制备一种复合负载碱性成纤维细胞生长因子的壳聚糖-肝素纳米粒子双层胶原基复合材料,并评价其生物安全性。方法:制备交联风干胶原膜和交联冻干胶原膜。将壳聚糖-肝素纳米粒滴于交联冻干胶原膜上,再将湿态交联风干胶原膜置于复合纳米粒子的交联冻干胶原膜上风干,即碱性成纤维细胞生长因子/双层胶原基复合材料。采用急性全身毒性试验、溶血试验、热原试验和细胞毒性试验评价其生物安全性。结果与结论:碱性成纤维细胞生长因子/双层胶原基复合材料为双层结构,一侧表面致密,另一侧疏松多孔。在其中间负载碱性成纤维细胞生长因子的壳聚糖-肝素纳米粒子呈不规则球形分布于胶原膜内侧面;急性全身毒性试验、热原试验、溶血试验均为阴性,细胞毒性为0级。说明碱性成纤维细胞生长因子/双层胶原基复合材料具有良好的生物安全性,对机体无毒,符合ISO10993-1评价标准。BACKGROUND: Collagen is a common used scaffold in tissue engineering, its specific molecular structure and biological activity are conducive to a variety of cell adhesion, proliferation and differentiation, and can speed up wound healing and degradation to provide sufficient space for new tissues.OBJECTIVE: To prepare a kind of inhomogeneous double layered collagen composite incorporated with basic fibroblast growth factor (bFGF) loaded chitosan-heparin (CS-Hep) nanoparticles, and to evaluate its biological safety.METHODS: The air-dried dense layer collagen membranes and freeze-dried loose layer collagen membrane were prepared respectively and then cross-linked by D-ribose (termed as CAM and CFM respectively).CS-Hep nanoparticles were prepared and then dropped on the surface of CFM.The wet CAM was laid on the surface of CFM with nanoparticles, and then air dried completely at 4 ℃.The obtained material was termed as bDM.Its physical and chemical properties were investigated.In addition, its bio-safety was also examined through acute systemic toxicity, pyrogen, hemolysis and cellular toxicity tests.RESULTS AND CONCLUSION: The bFGF/double-layered collagen composite was made up of double layers with one dense layer (CAM) and another loose layer (CFM).As part of bDM, CS-Hep nanopartiles with irregular global shape were aligned in the scope of D-period structure of the inner surface of CFM; the bFGF/double-layered collagen composite had no systemic acute toxicity, no cytotoxicity and pyrogen reactions as well as no hemolytic effect.The bFGF/double-layered collagen composite is prepared and found to have good biocompatibility and safety.Moreover, this material conforms to the ISO 10993-1, and can be used as a basic scaffold material in tissue engineering天津市科技支撑计划重点项目(08ZCKFSF02100);博士点基金项目(20101106110042)---