Study On 473nm All-Solid-State Blue Laser

LD泵浦全固体激光器(简称DPSSL)是当前世界激光产业研究的热点之一。它正逐步取代一些传统激光器，成为目前发展最为迅速的激光器，广泛应用于材料加工、医疗、军事等领域。 LD泵浦掺Nd3+激光介质，腔内倍频全固体蓝光激光器已成为获得蓝光最有效、最具商业价值的方法，进而成为一个研究热点。但目前瓦级全固体蓝光激光器的研究还不成熟，本文在理论和实验上进行研究，对全固体蓝光激光器的产业化具有一定的参考价值。主要工作如下： 1.介绍了Nd:YAG与Nd:YVO4的物理、光学特性，并比较它们准三能级跃迁的优、劣点，选取Nd:YAG作为激光介质，并对其激光特性进行详细的研究。介绍了能级理论，对Nd:YA...At present, LD-pumped solid state lasers (DPSSL) have been developed as one of vital domain in laser field. Furthermore, DPSSL have gradually replaced the traditional laser, which is mainly attributed to its perfect development and its wide applications, such as material processing, medicine, military and so on. LD-pumped Nd3+ lasers with intracavity frequency-doubling have proved to be a most e...学位：理学硕士院系专业：物理与机电工程学院物理学系_光学学号：20042402

理想声源辐射声场的数值分析

通过声场的特性和规律分析可以识别和定位噪声源,对噪声控制以及声源的设计提供参考。数值方法是求解有源声场的重要工具,复杂的声辐射一般可分解为简单的声辐射叠加。研究了单极子、偶极子、活塞等几种理想声源辐射声场的解析解,并用有限元法计算数值解,得到相应的辐射声场,包括声压、速度、指向性等量,有限元法得到的数值结果与解析解吻合;利用有限元法计算了点声源的线性阵列与平面阵列等典型的叠加声场。对各种声源的特性和辐射声场的规律以及在工程领域中的应用进行了归纳。国家自然科学基金项目(51505261);;山东省自然科学基金项目(ZR2015AM013

连续输出1.60W/473nm直腔蓝光激光器

报道了LD端面泵浦Nd∶YAG晶体,LBO腔内倍频473 nm全固态直腔蓝光激光器.根据谐振腔稳定性理论,利用简单的平-平腔直接测得不同泵浦功率下的热焦距值.通过数值计算分析了不同热焦距下,Nd∶YAG与LBO晶体中的腰斑半径以及LBO中光腰的位置,并在准三能级系统模型和倍频理论的指导下优化激光腔体结构,使激光器实现最佳的模式匹配和倍频效率,得到高效的蓝光激光输出.激光阈值为1.92 W;当泵浦激光功率为20.58 W时,473 nm蓝光的输出功率为1.60 W,光-光转化效率为7.8%

正确认识和处理“国家分配论”与“公共财政论”的关系

近年来，国内财政理论界关于中、西财政理论的比较研究逐步深入，尤其集中表现于在我国财政理论界长期占据主流地位的“国家分配论”与以西方经济分析方法为基础的“公共财政论”之间的比较研究上。随着时间的推移，理论界普遍认识到：“国家分配论”对财政本质的认识与剖..

魁蚶(Scapharca broughtonii)热休克蛋白90(HSP90)基因的克隆及转录表达分析

热休克蛋白90(HSP90)作为一种研究的常规免疫基因,在许多物种都有过报道。本研究从构建的魁蚶转录组文库中筛选得到的HSP90基因部分序列为基础,通过RACE技术获得其c DNA全长序列(命名为Sb HSP90),以期明确魁蚶HSP90基因的结构特征、组织分布及其对病原菌刺激的免疫变化规律。序列和结构分析表明,该c DNA全长2707bp,编码一个由728个氨基酸组成的多肽,该多肽含有HSP90家族共有的5个签名序列,C端高度保守的MEEVD短肽序列和ATPase结构域;预测蛋白的分子量(Mw)为83.72k Da,理论等电点(p I)为4.85;预测该蛋白无信号肽,具有4个糖基化位点。同源性及系统分析表明,Sb HSP90基因与软体动物的HSP90相似性达到83%以上,其中与长牡蛎(Crassostrea gigas)和海湾扇贝(Argopecten irradians)相似度最高达86%,与甲壳动物HSP90的相似度都在81%左右,与脊椎动物HSP90-α和HSP90-β的同源性都很接近。实时荧光定量PCR(q RT-PCR)结果表明:Sb HSP90 m RNA在魁蚶血细胞、斧足、鳃、外套膜、闭壳肌和肝胰腺和中均有表达,斧足中的表达量相对较高,而在肝胰腺中的表达量则相对较低;注射鳗弧菌后,相对于对照组,Sb HSP90基因在所检测的每个组织中m RNA水平上的表达量都显著上调(P<0.01),而且具有显著的时间依赖性和瞬时表达趋势。国家自然科学基金项目,31602142号;;中国水产科学研究院基本科研业务费项目,2017GH07号;;浙江省重中之重学科开放基金,KF2015007

Expression of pin1 gene in lung cancer and its significance

背景与目的:Pin是人类高度保守的特异性磷酸化肽基脯氨酰顺及异构酶,它作用于脯氨酸所形成的肽键,并且仅使磷酸化pSer/Thr-Pro发生异构化,这一磷酸化后调控机制能诱导磷酸蛋白的构像变化,使其发挥功能。近来的研究显示这种新的调控机制在许多生理过程中起重要的调节作用,一旦失调便导致一系列人类疾病。如癌症患者体内Pin1表达异常增高,并调控多种癌基因的信号通路。本研究探讨pin1基因在非小细胞肺癌(NSCLC)中的表达及其意义。方法:利用免疫组织化学方法、定量PCR方法分别检测肺癌组织和正常肺组织中Pin1基因在翻译水平和mRNA水平上的表达差异。结果:在蛋白质水平上,Pin1的表达在正常/癌两种不同的肺组织中,表达量差异有显著性;而在mRNA水平上,Pin1的表达量在正常/癌两种不同的肺组织中,差异无显著性。结论:Pin1在NSCLC组织中的表达,可能是在翻译水平受到了调控;我们的研究进一步证实:Pin1在NSCLC组织中存在蛋白水平的过量表达,这对利用Pin1作为NSCLC组织检测标志物提供了理论依据。Background and purpose:Pin1 is a highly conservative enzyme that isomerizes only the phosphorylated Ser/Thr-Pro bonds in certain proteins, thereby inducing conformational changes. Recent results indicate that such conformational changes following phosphorylation are a novel signaling mechanism pivotal in regulating many cellular functions. Overexpression of Pin1 is prevalently found in human cancers.We studied expression of pin1 in non-small cell lung cancer and its implication in clinical. Methods:We detected the differential expression level of Pin1 protein in lung cancer specimen and normal lung tissues by immunohistochemical staining. Real-time quantitative PCR was also applied to detect the mRNA differential expression level in lung cancer tissues and normal lung tissues. Results:Pin1 protein is overexpressed in lung cancer at the protein level. On the other hand, the expression level of Pin1 mRNA in lung cancer tissue has no significant change compared with normal tissue. Conclusion:It demonstrated that the Pin1 expression in lung cancer might be regulated by translation mechanism.Our data implicate that Pin1 may serve as a valuable molecular marker for human cancer

端面泵浦Nd∶YAG连续输出1052nm波长激光器

设计了一个简单紧凑的1052nm波长激光器。首次利用激光二极管(LD)端面泵浦Nd∶YAG晶体,使用镀有高度选择性介质膜的反射镜产生该波段的激光。激光阈值为0.3W,当808nm波长泵浦光功率达到18W时产生了3.5W的1052nm波长激光输出。光-光转换效率为20%,输出激光功率波动不超过3%

Spreading area and shape regulate apoptosis and differentiation of osteoblasts

The in vivo observations have indicated that at the remodeling sites of bone, the spreading area or shape of preosteoblasts is confined by the mineralized matrix. But it remains unknown whether this spreading confinement regulates the differentiation or apoptosis of osteoblasts. In the present study, osteoblast-like cells (MC3T3-E1) were seeded on micropatterned islands with different area and shape. The expression of three osteogenic differentiation markers was measured by immunofluorescence staining and apoptotic cells were detected using a terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labelling assay kit. The membrane fluorescence staining results showed that the actual spreading area of micropatterned osteoblasts coincided with the designed value. When the area of a micropatterned cell was confined as 314 or 615 mu m(2), which was lower than that of freely spreading osteoblasts, the circular shape promoted the expression of osteogenic differentiation markers and the percentage of apoptotic osteoblasts compared with the branched shape. This shape-regulated differentiation and apoptosis of osteoblasts with confined spreading area were abolished when actin polymerization was inhibited by cytochalasin D. The present study gives an insight into the roles of spreading morphology on osteoblastic differentiation and apoptosis

第十八届美国理论与应用力学大会总结

1会议概况2018年6月5—9日,第18届美国理论与应用力学大会(18th U.S. National Congress of Theoretical and Applied Mechanics, USNCTAM2018)在美国芝加哥召开.本次大会由美国力学国家委员会和中国力学学会联合主办,旨在探讨和交流近四年世界范围内在理论和应用力学领域的基础研究、创新技术的最新进展,吸引了来自世界各地的近千名专家学

High LUMO energy level C60(OCH3)4 derivatives:Electronic acceptors for photovoltaiccellswithhigheropen-circuitvoltage

E-mail Addresses: [email protected] regioselective C-60(OCH3)(4) derivatives, C-60(OCH3)(4)-PCBM (a methanofullerene derivative of C-60(OCH3)(4), PCBM=[6,6]-phenyl-C-61-butyric acid methyl ester) and C-60(OCH3)(4)-APCBM (an aziridinofullerene derivative of C-60(OCH3)(4)) were synthesized from C60Cl6 and used as acceptor for polymer solar cells. Revealed by cyclic voltammetry, the LUMO energy levels of C-60(OCH3)4-APCBM and C-60(OCH3)(4)-PCBM are 0.2 and 0.3 eV higher than that of PCBM, respectively. For the polymer photovoltaic cells with fullerene (PCBM, C-60(OCH3)(4)-APCBM or C-60(OCH3)(4)-PCBM) acceptor in combination with poly(3-hexylthiophene) (P3HT) donor, the open-circuit voltage is increased from 0.58 V (for PCBM) to 0.63 V (for C-60(OCH3)(4)-APCBm) and 0.72 V (for C-60(OCH3)(4)-PCBM). The higher open-circuit voltages are reasonably attributed to the higher LUMO levels of the C-60(OCH3)(4) derivatives because of four electron-donating methoxy groups attached. The photovoltaic performance of C-60(OCH3)(4)-PCBMbased device is higher than that involving C-60(OCH3)(4)-APCBM, largely due to the structural changeability of C-60(OCH3)(4)-APCBM resulting from the rotatable N-C bond bridge therein. This work demonstrates that fullerene derivatives with higher LUMO level can be functionalized from multiaddition of electron-donating groups, and exemplifies that photovoltaic performances of fullerene-based solar cells are sensitive even to trivial bridge between functional group and fullerene core. (C) 2012 Elsevier B.V. All rights reserved .National Nature Science Foundation of China U1205111 21031004 21021061 J1210014 20923004 National Basic Research 973 Program of China 2011CB93590