56 research outputs found

    厦门市某医院体检人群中有机氯农药暴露与胆石症发病的关联性研究

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    目的探讨厦门市第二医院体检人群中有机氯农药暴露与胆结石发生的关联及其发病危险因素。方法收集2015年2月-8月在医院健康体检人群中经B超确诊的新发胆囊结石患者100例,以同期参加体检的非胆囊结石者为对照,进行1∶2配比的病例对照研究。进行流行病学调查,采用气相色谱联用电子捕获器检测研究对象外周血中有机氯农药水平。应用多因素条件Logistic回归模型分析有机氯农药与胆囊结石发病的关系。结果病例组血清中α-HCH残留水平高于对照组,差异有统计学意义;Logistic回归分析非酒精性脂肪肝、2型糖尿病、血清α-HCH含量增高可能增加胆结石的患病危险,OR值及95%CI分别为5.134(1.952~13.502)、4.754(1.849~12.220)和1.357(1.094~1.854)。结论环境有机氯农药暴露可能是胆囊结石病发生的危险因素。厦门市科技计划项目(3502Z20163006);厦门市集美区科技计划项目(20142C01);厦门大学校长基金(20720152012)

    低龄DDH患儿初次开放复位术中股骨截骨必要性的前瞻性随机对照试验研究方案

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    回顾性研究发现,股骨截骨术并非低龄DDH患儿手术治疗所必须的,而应根据患儿具体情况合理选择;本研究通过多中心前瞻性研究进一步探讨对于18个月至3岁DDH患儿是否要行股骨截骨术。FSODDH项目为一项多中心前瞻性随机对照临床试验研究。研究设计拟招募200名单侧低龄DDH患儿,随机分成股骨截骨组(n=100)和股骨不截骨组(n=100)。股骨截骨组患儿全部采取髋关节开放复位术、骨盆截骨术及股骨截骨术治疗;股骨不截骨组患儿全部采取髋关节开放复位术及骨盆截骨术治疗;术后定期随访至少2年。收集术前、术后1周、术后1个月、术后3个月、术后6个月、术后1年及术后2年的髋关节正位X线影像资料,比较两组患儿的髋臼指数、股骨头坏死率、再脱位率、术中出血量、手术时间和住院天数等临床指标。这一多中心前瞻性研究将能为低龄DDH患儿是否需行股骨截骨术提供循证医学证据

    Genomic Insights into the Formation of Human Populations in East Asia

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    厦门大学人类学研究所、厦门大学生命科学学院细胞应激生物学国家重点实验室王传超教授课题组与哈佛医学院David Reich教授团队合作,联合全球43个单位的85位共同作者组成的国际合作团队通过古DNA精细解析东亚人群形成历史。研究人员利用古DNA数据检验了东亚地区农业和语言共扩散理论,综合考古学、语言学等证据,该研究系统性地重构了东亚人群的形成、迁徙和混合历史。这是目前国内开展的东亚地区最大规模的考古基因组学研究,此次所报道的东亚地区古人基因组样本量是以往国内研究机构所发表的样本量总和的两倍,改变了东亚地区尤其是中国境内考古基因组学研究长期滞后的局面。 该研究是由王传超教授团队与哈佛医学院(David Reich教授)、德国马普人类历史科学研究所(Johannes Krause教授)、复旦大学现代人类学教育部重点实验室(李辉教授和金力院士)、维也纳大学进化人类学系(Ron Pinhasi副教授)、南洋理工大学人文学院(Hui-Yuan Yeh助理教授)、俄罗斯远东联邦大学科学博物馆(Alexander N Popov研究员)、西安交通大学(张虎勤教授)、蒙古国国家博物馆研究中心、乌兰巴托国立大学考古系、华盛顿大学人类学系、台湾成功大学考古所、加州大学人类学系等全球43个单位的85位共同作者组成的国际合作团队联合完成的。厦门大学人类学研究所、厦门大学生命科学学院细胞应激生物学国家重点实验室为论文第一完成单位。厦门大学人类学研究所韦兰海副教授、胡荣助理教授、郭健新博士后、何光林博士后和杨晓敏硕士参与了研究工作。The deep population history of East Asia remains poorly understood due to a lack of ancient DNA data and sparse sampling of present-day people1,2. We report genome-wide data from 166 East Asians dating to 6000 BCE-1000 CE and 46 present-day groups. Hunter-gatherers from Japan, the Amur River Basin, and people of Neolithic and Iron Age Taiwan and the Tibetan plateau are linked by a deeply-splitting lineage likely reflecting a Late Pleistocene coastal migration. We follow Holocene expansions from four regions. First, hunter-gatherers of Mongolia and the Amur River Basin have ancestry shared by Mongolic and Tungusic language speakers but do not carry West Liao River farmer ancestry contradicting theories that their expansion spread these proto-languages. Second, Yellow River Basin farmers at ~3000 BCE likely spread Sino-Tibetan languages as their ancestry dispersed both to Tibet where it forms up ~84% to some groups and to the Central Plain where it contributed ~59-84% to Han Chinese. Third, people from Taiwan ~1300 BCE to 800 CE derived ~75% ancestry from a lineage also common in modern Austronesian, Tai-Kadai and Austroasiatic speakers likely deriving from Yangtze River Valley farmers; ancient Taiwan people also derived ~25% ancestry from a northern lineage related to but different from Yellow River farmers implying an additional north-to-south expansion. Fourth, Yamnaya Steppe pastoralist ancestry arrived in western Mongolia after ~3000 BCE but was displaced by previously established lineages even while it persisted in western China as expected if it spread the ancestor of Tocharian Indo-European languages. Two later gene flows affected western Mongolia: after ~2000 BCE migrants with Yamnaya and European farmer ancestry, and episodic impacts of later groups with ancestry from Turan.We thank David Anthony, Ofer Bar-Yosef, Katherine Brunson, Rowan Flad, Pavel Flegontov,Qiaomei Fu, Wolfgang Haak, Iosif Lazaridis, Mark Lipson, Iain Mathieson, Richard Meadow,Inigo Olalde, Nick Patterson, Pontus Skoglund, Dan Xu, and the four reviewers for valuable comments. We thank Naruya Saitou and the Asian DNA Repository Consortium for sharing genotype data from present-day Japanese groups. We thank Toyohiro Nishimoto and Takashi Fujisawa from the Rebun Town Board of Education for sharing the Funadomari Jomon samples, and Hideyo Tanaka and Watru Nagahara from the Archeological Center of Chiba City who are excavators of the Rokutsu Jomon site. The excavations at Boisman-2 site (Boisman culture), the Pospelovo-1 site (Yankovsky culture), and the Roshino-4 site (Heishui Mohe culture) were funded by the Far Eastern Federal University and the Institute of History,Archaeology and Ethnology Far Eastern Branch of the Russian Academy of Sciences; research on Pospelovo-1 is funded by RFBR project number 18-09-40101. C.C.W was funded by the Max Planck Society, the National Natural Science Foundation of China (NSFC 31801040), the Nanqiang Outstanding Young Talents Program of Xiamen University (X2123302), the Major project of National Social Science Foundation of China (20&ZD248), a European Research Council (ERC) grant to Dan Xu (ERC-2019-ADG-883700-TRAM) and Fundamental Research Funds for the Central Universities (ZK1144). O.B. and Y.B. were funded by Russian Scientific Foundation grant 17-14-01345. H.M. was supported by the grant JSPS 16H02527. M.R. and C.C.W received funding from the ERC under the European Union’s Horizon 2020 research and innovation program (grant No 646612) to M.R. The research of C.S. is supported 30 by the Calleva Foundation and the Human Origins Research Fund. H.L was funded NSFC (91731303, 31671297), B&R International Joint Laboratory of Eurasian Anthropology (18490750300). J.K. was funded by DFG grant KR 4015/1-1, the Baden Württemberg Foundation, and the Max Planck Institute. Accelerator Mass Spectrometry radiocarbon dating work was supported by the National Science Foundation (NSF) (BCS-1460369) to D.J.K. and B.J.C. D.R. was funded by NSF grant BCS-1032255, NIH (NIGMS) grant GM100233, the Paul M. Allen Frontiers Group, John Templeton Foundation grant 61220, a gift from Jean-Francois Clin, and the Howard Hughes Medical Institute. 该研究得到了国家自然科学基金“中国东南各族群的遗传混合”、国家社科基金重大项目“多学科视角下的南岛语族的起源和形成研究”、厦门大学南强青年拔尖人才支持计划A类、中央高校基本科研业务费等资助

    research on ultra-short wave wireless network planning method

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    为改进超短波无线网络的构建方式,研究在给定若干必要网络节点的条件下,增加机动节点构成最优网络的方法。为平衡网络的建设成本、可靠性和通信质量的关系,设计一个分层优化模型,并提出分层多目标优化近似算法求解该模型,根据目标函数的优先层次求得满足约束条件的近似最优解。仿真结果表明,该算法能找到与最优解近似甚至相同的解。与GLiD算法相比,其规划的网络成本更低,可靠性和通信质量更好。In order to improve the traditional way of ultra-short wave wireless network construction, this paper studies how to form the optimal network by adding mobile nodes to a group of necessary nodes. In order to achieve the balance of network construction cost, reliability and communication quality, it designs a hierarchical optimization model. To solve this model, it proposes a hierarchical multi-objective optimization approximation algorithm. According to the priority levels of objective functions, the algorithm can achieve the approximate optimal solution which meets constraints. Simulation results show that this algorithm can effectively achieve the approximate or even the same solution as the optimal solution. Compared with the GLiD algorithm, this algorithm can plan a better network with less construction cost, higher reliability and better communication quality

    全节点空间MPI同步通信死锁检测

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    针对全节点空间上MPI同步通信程序死锁检测的现有穷举方法的弱点,提出了该场景中MPI程序的两种参数化模型:一次参数化模型和二次参数化模型。通过分析一次参数化模型的一类不变式的性质,给出了该模型的死锁检测算法。提出了同构节点空间的一系列概念和性质并由此设计出该算法的几种优化方法,以加快某些特定程序模型死锁检测的过程。仿真实验表明该算法及其优化方法比现有方法的性能提高若干数量级

    比例方程组与MPI同步通信静态死锁检测

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    介绍了一种MPI程序死锁检测的静态方法以及该方法所处理的程序模型.为实现该方法,提出了比例方程组(一种特殊线性方程组)的概念并设计了求解方程组最简解的线性时空复杂度的高效算法.算法由一个四遍扫描过程与一个主控程序构成.主控程序用来处理并行计算节点计算机构成的划分.四遍扫描过程采用深度优先搜索方法确定方程组中各变元之间的比例关系.通过该算法所获得的最简解,任意多个变元之间的比例关系能在常数时间内获得.证明了该算法的正确性,并采用Java语言实现了该算法的标准程序库.该程序库目前已运行于MPI同步通信静态死锁检测的软件框架中

    Static Detection Algorithm of Deadlock in MPI Synchronization Communication Sequential Model

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    静态检测MPI程序同步通信死锁比较困难,通常需要建立程序模型.顺序模型是其他所有复杂模型的基础.通过一种映射方法将顺序模型转化为字符串集合,将死锁检测问题转化为等价的多队列字符申匹配问题,从而设计并实现了一种MPI同步通信顺序模型的静态死锁检测算法.该算法的性能优于通常的环检测方法,并能适应动态消息流

    an application of six sigma in system integration process

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    6Sigma是实现过程控制和持续改进的有效方法,本文针对复杂系统集成过程管理存在的问题,分析了6Sigma在系统集成过程管理中应用的可行性,提出了一种基于6Sigma的系统集成过程模型.该模型具有信息及时反馈、过程持续改进、提高质量和降低成本的特点,在项目中得到应用并取得明显效果

    a libmini-based real-time algorithm for dynamic terrain rendering

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    为了减少地形动态变化时的地形计算时间,满足动态地形实时可视化的需要,在地形渲染库libMini的基础上,依据地形动态变化的局部性特点,以及库中LOD(Level ofDetail)算法的具体实现方式,运用局部更新的思想,提出了一种动态地形实时计算和渲染算法.算法避免了在地形动态变化时进行大量重复计算,使得在地形动态变化时所需的计算量大大减少,达到实时渲染要求.实验表明,算法使得局部地形动态变化时地形计算和渲染的时间从秒级降低到毫秒级,可以满足实时渲染要求
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