Results of in vivo nanomaterials testing using minipig

Using in vivo experiments we tested healing of a fresh wound treated with a nanofibrous cover. From predefined wounds, samples were taken at regular intervals for histological analysis, wound measurements and photodocumentation were performed

Results of the realisation of the experiments using large experimental animals – application of cells/ stem cells using different vectors, diagnostics

A design of methods to test application of cells/ stem cells using different vectors, solution of the application including diagnostics and connected agenda

Results of the realisation of the experiments using the experimental animals

A design of methods to test a functionality of inovative replacements, solution of the replacement incl. implantation and connected agenda

Results of nanomaterials testing for skin wounds nursing

Using minipigs experiments, we tested the healing of fresh wounds treated with different nanofibrous materials and compared them with standard treatment. From predefined wounds, samples were taken at regular intervals for histological analysis, microbiology, wound measurements and photodocumentation. Blood was also collected from the miniprasate to determine pro-inflammatory cytokines

In vivo IBD using minipig course results

Innovative approaches testing of Inflammatory Bowel Disease on minipigs

Implant study protocol including results

Testing and analysis of implant material and design in real environment

Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice

We examined the anti-inflammatory effects of the combination of thyme and oregano essential oil dietary administered at three concentrations (0.4% thyme and 0.2% oregano oils; 0.2% thyme and 0.1% oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis. Treatment of colitic animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines IL-1β, IL-6, GM-CSF, and TNFα, especially after application of the medium dose. The medium dose of the essential oils significantly lowered the amount of IL-1β and IL-6 proteins too. Moreover, administration of the medium dose decreased the mortality rate, accelerated the body weight gain recovery, and reduced the macroscopic damage of the colonic tissue. Our results indicate that combined treatment with appropriate concentrations of thyme and oregano essential oils can reduce the production of proinflammatory cytokines, and thereby attenuate TNBS-induced colitis in mice

Geomorphic response of dry valley basin to large-scale land use changes in the second half of the 20th century and problems with its reconstruction

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