The Mitochondrial DNA Control Region Might Have Useful Diagnostic and Prognostic Biomarkers for Thyroid Tumors

The literature suggests that mitochondrial DNA (mtDNA) defects are associated with a large number of diseases including cancers. The role of mtDNA variations in thyroid cancer is a highly controversial topic. Therefore, we investigated the role of mt-DNA control region (CR) variations in thyroid tumor progression and the influence of mtDNA haplogroups on susceptibility to thyroid tumors. For this purpose, in total, 108 hot thyroid nodules (HTNs), 95 cold thyroid nodules (CTNs), 48 papillary thyroid carcinoma (PTC) samples with their surrounding tissues and 104 healthy control subjects' blood samples were screened for all mtDNA CR variations using Sanger sequencing. We found that MtDNA haplogroup U was significantly associated with susceptibility to benign thyroid entities. In addition, eight single nucleotide polymorphisms (SNPs) (T146C, G185A, C194T, C295T, G16129A, T16304C, A16343G and T16362C) in the mtDNA CR were associated with the occurrence of benign and malign thyroid nodules in the Turkish population. As compared with samples taken from a healthy Turkish population and HTNs, the frequency of C7 repeats in D310 polycytosine sequence was found to be higher in CTNs and the PTC samples. In addition, the frequency of somatic mutations in mtMSI regions including T16189C and D514 CA dinucleotide repeats were found to be higher in PTC samples than benign thyroid nodules. Conversely, the frequency of somatic mutations in D310 was found to be higher in HTNs than CTNs and PTCs. In conclusion, mtDNA D310 instability does not play a role in the tumorigenesis of PTC but the results indicate that it might be used as a diagnostic clonal expansion biomarker for premalignant thyroid tumor cells. In addition, D514 CA instability might be considered as a prognostic biomarker for benign to malign transformation in thyroid tumors.Research Fund of the Tekirdag Namik Kemal University [NKUBAP.00.10.AR.14.07, NKUBAP.00.10.AR.15.05]This work was supported by two grants from the Research Fund of the Tekirdag Namik Kemal University, project numbers NKUBAP.00.10.AR.14.07 and NKUBAP.00.10.AR.15.05

Relation between mothers’ types of labor, birth interventions, birth experiences and postpartum depression: A multicentre follow-up study

PubMed ID: 30420081Aim: This definitive and cross-sectional study was conducted to determine the relation between mothers’ types of labor, birth interventions, birth experiences and postpartum depression. Methods: A total of 1010 mothers who gave birth in four different provinces of Turkey were chosen to participate in the study via purposive sampling method Results: The Edinburgh Postpartum Depression Scale score was determined to be 13 and over in 36.4% of the women. In this study, it was determined that the Edinburgh Postpartum Depression Scale scores for women in the 18–24 age group who had a vaginal birth, did not have health insurance, experienced health problems during pregnancy and were not trained about type of labor during pregnancy were statistically higher. There was no significant correlation between the birth experiences and postpartum depression. The linear regression model showed that there was a statistically significant correlation between enema and amniotomy interventions practised during the birth and the Edinburgh Postpartum Depression Scale scores. Conclusion: In conclusion, it is thought that preparing the mothers for birth with birth preparation training in the antenatal period and imposing the necessary regulations in the delivery room for the mothers to have a positive birth experience are important in reducing postpartum depression risk. © 2018Firat University Scientific Research Projects Management UnitThe authors would like to thank the Ege University Scientific Research Projects Committee for financial support that greatly improved the manuscript and the participants of the study for their cooperation, which was greatly appreciated. -

The radioluminescence and optical behaviour of nanocomposites with CdSeS quantum dot

In this work, highly luminescent alloyed CdSeS QDs are successfully synthesized by two phase route method by using oleic acid (OA) as a surfactant. OA capped CdSeS QDs prepared in two different synthesis duration were compared in terms of luminescence and optical properties. The nanocomposites blended with CdSeS QDs which have highly luminescent efficiency in different ratios by Low Density Polyethylene (LDPE) and these nanocomposites were mainly investigated radioluminescence (RL) and optical properties (UV/VIS absorption). Structural, morphological, thermal properties of the nanocrystal and nanocomposites were examined using; XRD, FT-IR, TEM, SEM, TG-DTA techniques. OA capped CdSeS and also nanocomposites were showed two RL spectrum peaks in green and red region at around 528 nm and 710 nm respectively. Also, it is seen that the radioluminescence intensity changes linearly with the particle size of the QDs and about 12% size change of quantum dot led to a threefold increase in RL intensity. The luminescence glow curves are in compliance with absorption and fluorescence spectra. The absorption bands showed a significant blue shift for the nanocomposites as compare to powder CdSeS. The optical band gap of the OA capped CdSeS calculated as 1.77 eV. It was observed that the optical band gap of LDPE was decreased by the adding ratio of CdSeS from 3.71 eV to 2.25 eV. © 2017 Elsevier B.V

Relation between mothers’ types of labor, birth interventions, birth experiences and postpartum depression: A multicentre follow-up study

Aim: This definitive and cross-sectional study was conducted to determine the relation between mothers’ types of labor, birth interventions, birth experiences and postpartum depression. Methods: A total of 1010 mothers who gave birth in four different provinces of Turkey were chosen to participate in the study via purposive sampling method Results: The Edinburgh Postpartum Depression Scale score was determined to be 13 and over in 36.4% of the women. In this study, it was determined that the Edinburgh Postpartum Depression Scale scores for women in the 18–24 age group who had a vaginal birth, did not have health insurance, experienced health problems during pregnancy and were not trained about type of labor during pregnancy were statistically higher. There was no significant correlation between the birth experiences and postpartum depression. The linear regression model showed that there was a statistically significant correlation between enema and amniotomy interventions practised during the birth and the Edinburgh Postpartum Depression Scale scores. Conclusion: In conclusion, it is thought that preparing the mothers for birth with birth preparation training in the antenatal period and imposing the necessary regulations in the delivery room for the mothers to have a positive birth experience are important in reducing postpartum depression risk. © 201