Evalaution of radioiodination of synthesised meta-iodobenzylguanidine catalyzed by in situ generated Cu(i)

Meta-iodobenzylguanidine (m-IBG) is a biogenic amine precursor, noradrenaline analogue, which is actively taken up by tumors. In tracer amounts, [123/131I]-m-IBG is used as a radiopharmaceutical to target normal and malignant tissues of neuroadrenergic origin for diagnostic scintigraphy, and labeled with higher activities of 131I, it is used for therapy of phenochromocytoma and neuroblastoma. The increased clinical therapeutic use of unlabeled m-IBG at doses of up to 40 mg/m2 emphasizes the need for syntheses and an established quality protocol for this substance that relies on verifiable analytical parameters. Evaluation of radioiodination was necessary to obtain higher labeling yield (we achieved over 90% instead no more than 70%), because isotopic exchange labeling of m-IBG with 131I catalyzed by Cu(I) is much more efficient than with conveniently used ammonium sulphate.Physical chemistry 2006 : 8th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 26-29 September 200

99mTc-hexakis-(2-metoxy-isobutyl-isonitrile) ( 99mTc-MIBI) a new myocardial imaging agent: synthesis of MIBI, optimising conditions for radiolabelling with 99mTc at high radiochemical purity and in vivo behavior

99mTc-MIBI is a promising radiopharmaceutical for myocardial perfusion imaging agent, but it has also shown good results in identifying several types of tumors, such as breast, lung and thyroid cancers. It is a lipophilic, cationic technetium (1) complex. In this paper a complete study on the synthesis of 2-metohy-isobutyl-isonitrile (MIBI) as well as a formulation of a lyophilized kit for labeling with 99mTc is presented. Investigation on effective factors as well as finding out the optimum parameters to obtain the highest labelling efficiency and radiochemical purity of 99mTc-MIBI complex were performed. The radiochemical purity of the labelled preparation was high (>95%). Biodistribution study performed in health male Wistar rats showed satisfactory biokinetics results. 99mTc-MIBI was accumulated in sufficient amount into the hearth tissue for myocardial perfusion imaging. MIBI in kit formulation was found to be stable and also safe for administration.Physical chemistry 2006 : 8th international conference on fundamental and applied aspects of physical chemistry; Belgrade (Serbia); 26-29 September 200

Supplementary material for the article: Jeremic, S.; Beškoski, V. P.; Djokic, L.; Vasiljevic, B.; Vrvić, M. M.; Avdalović, J.; Gojgić Cvijović, G.; Beškoski, L. S.; Nikodinovic-Runic, J. Interactions of the Metal Tolerant Heterotrophic Microorganisms and Iron Oxidizing Autotrophic Bacteria from Sulphidic Mine Environment during Bioleaching Experiments. Journal of Environmental Management 2016, 172, 151–161. https://doi.org/10.1016/j.jenvman.2016.02.041

Supplementary material for: [https://doi.org/10.1016/j.jenvman.2016.02.041]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/1915

Assessment of soil erosion rates in Southeastern Serbia using nuclear techniques

Erozija zemljišta vodom predstavlja vaţan problem zaštite ţivotne sredine u Srbiji. Posledica erozije je degradacija zemljišnih resursa, smanjenje plodnosti zemljišta i redukcija poljoprivredne proizvodnje. Najveši intenzitet erozije uoţen je na obradivom zemljištu na strmim padinama. Pretvaranje pašnjaka u obradivo zemljište uticalo je na povešanje prostora zahvašenih procesom erozije. U ovom radu prikazani su preli-minarni rezultati projekta tehniţke saradnje sa MeŤunarodnom agencijom za atomsku energiju ̳Jaţanje kapaciteta za procenu intenziteta erozije zemljišta koriššenjem nuklearnih tehnika u cilju podrške odrţivom upravljanju zemljištem‘ (SRB5003) ţiji je cilj procena intenziteta erozije zemljišta 137Cs-metodom. Istraţivanja sprovedena u basenima Pţinje i Juţne Morave ukazala su na intenzivnu eroziju na ovom prostoru. Istraţivanja še biti nastavljena na nekoliko drugih lokacija, a rezultati še biti upotrebljeni za podršku nacionalnim programima konzervacije zemljišta.Soil erosion by water presents an important environmental problem in Serbia resulting in degradation of the soil resources, reducing soil fertility and agricultural production. The highest intensity of erosion was observed at cultivated land occupying steep slopes. The conversion of pastures to arable land enhances this problem. This study presents the preliminary results of Technical Cooperation Project of International Atomic Energy Agency ̳Strengthening the Capacities for Soil Erosion Assessment Using Nuclear Techniques to Support Implementation of Sustainable Land Management Practices‘(SRB5003) aimed at estimation of soil erosion rates using the 137Cs-method. The investigation of Pčinja and South Morava River Basins in southeastern Serbia revealed intensive erosion in the area. The investigation will continue at several other sites and the results will be used to support national soil conservation policy.Proceedings: [http://vinar.vin.bg.ac.rs/handle/123456789/8681]XXX симпозијум ДЗЗСЦГ (Друштва за заштиту од зрачења Србије и Црне Горе), 2- 4. октобар 2019. године, Дивчибаре, Србиј

Production of bacterial nanocellulose (BNC) and its application as a solid support in transition metal catalysed cross-coupling reactions

Bacterial nanocellulose (BNC) emerged as an attractive advanced biomaterial that provides desirable properties such as high strength, lightweight, tailorable surface chemistry, hydrophilicity, and biodegradability. BNC was successfully obtained from a wide range of carbon sources including sugars derived from grass biomass using Komagataeibacter medellinensis ID13488 strain with yields up to 6 g L-1 in static fermentation. Produced BNC was utilized in straightforward catalyst preparation as a solid support for two different transition metals, palladium and copper with metal loading of 20 and 3 wt%, respectively. Sustainable catalysts were applied in the synthesis of valuable fine chemicals, such as biphenyl-4-amine and 4'-fluorobiphenyl-4-amine, used in drug discovery, perfumes and dye industries with excellent product yields of up to 99%. Pd/BNC catalyst was reused 4 times and applied in two consecutive reactions, Suzuki-Miyaura cross-coupling reaction followed by hydrogenation of nitro to amino group while Cu/BNC catalyst was examined in Chan-Lam coupling reaction. Overall, the environmentally benign process of obtaining nanocellulose from biomass, followed by its utilisation as a solid support in metal-catalysed reactions and its recovery has been described. These findings reveal that BNC is a good support material, and it can be used as a support for different catalytic systems.This is the peer-reviewed version of the article: Jeremic, S., Djokic, L., Ajdačić, V., Božinović, N., Pavlovic, V., Manojlović, D. D., Babu, R., Senthamaraikannan, R., Rojas, O., Opsenica, I., & Nikodinovic-Runic, J. (2019). Production of bacterial nanocellulose (BNC) and its application as a solid support in transition metal catalysed cross-coupling reactions. International Journal of Biological Macromolecules, 129, 351–360. [https://doi.org/10.1016/j.ijbiomac.2019.01.154][https://www.sciencedirect.com/science/article/abs/pii/S0141813018349213?via%3Dihub

Supplementary data for article: Đokić-Stojanović, D. R.; Todorović, Z. B.; Troter, D. Z.; Stamenković, O. S.; Veselinović, L. M.; Zdujić, M. V.; Manojlović, D. D.; Veljković, V. B. Triethanolamine as an Efficient Cosolvent for Biodiesel Production by Cao-Catalyzed Sunflower Oil Ethanolysis: An Optimization Study. Hemijska Industrija 2019, 73 (6), 351–362. https://doi.org/10.2298/HEMIND190822033D

Supplementary material for: [https://doi.org/10.2298/HEMIND190822033D]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3797

Triethanolamine as an efficient cosolvent for biodiesel production by cao-catalyzed sunflower oil ethanolysis: An optimization study

Triethanolamine was applied as an efficient „green“ cosolvent for biodiesel production by CaO-catalyzed ethanolysis of sunflower oil. The reaction was conducted in a batch stirred reactor and optimized with respect to the reaction temperature (61.6-78.4 °C), the ethanol-to-oil molar ratio (7:1-17:1) and the cosolvent loading (3-36 % of the oil weight) by using a rotatable central composite design (RCCD) combined with the response surface methodology (RSM). The optimal reaction conditions were found to be: the ethanol-to-oil molar ratio of 9:1, the reaction temperature of 75 °C and the cosolvent loading of 30 % to oil weight, which resulted in the predicted and actual fatty acid ethyl ester (FAEE) contents of 98.8 % and 97.9±1.3 %, respectively, achieved within only 20 min of the reaction. Also, high FAEE contents were obtained with expired sunflower oil, hempseed oil and waste lard. X-ray diffraction analysis (XRD) was used to understand the changes in the CaO phase. The CaO catalyst can be used without any treatment in two consecutive cycles. Due to the calcium leaching into the product, an additional purification stage must be included in the overall process.Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3798

Supplementary data for article: Đokić-Stojanović, D. R.; Todorović, Z. B.; Troter, D. Z.; Stamenković, O. S.; Veselinović, L. M.; Zdujić, M. V.; Manojlović, D. D.; Veljković, V. B. Triethanolamine as an Efficient Cosolvent for Biodiesel Production by Cao-Catalyzed Sunflower Oil Ethanolysis: An Optimization Study. Hemijska Industrija 2019, 73 (6), 351–362. https://doi.org/10.2298/HEMIND190822033D

Supplementary material for: [https://doi.org/10.2298/HEMIND190822033D]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3797

Effect of crop density on yield and quality of alfalfa forage from combined use (forage-seed)

In Serbia, alfalfa is the most important perennial forage legume that is grown at 180-200 thousand hectares. Except for the classic production of forage, alfalfa is very important for seed production. In our conditions Alfalfa seed are produced from the second cut of alfalfa. Higher seed yields are achieved in larger distances between rows. In this system of production first and third cut are used for fodder. This trial tests three different densities and four varieties in order to determine the impact on yield and quality of forage dry matter. In the year of establishment, cultivars from the treatment A1 achieved higher yields of dry matter for 2.3 t ha-1 in relation to the treatment A2. In the second year, yield was higher by 1.4 t ha-1, and in the third higher for 3.1 t ha-1. Treatment A1 compared to A3 treatment had a higher yield of 3.5 t ha-1 (52%). In the second year treatment A1 achieved higher yields of forage then treatment A3 for 3.8 t ha-1 (44%), and in the third year for 4.6 t ha-1 (56%). Cultivars were also significantly affected the yield of forage dry matter at all densities. Influence of density and variety to the chemical composition of forage and the content of macro elements in the forage had no significant effect