HAEMATOLOGICAL STATUS IN CATS WITH CHRONIC RENAL FAILURE: EFFECT OF A RENAL DIET

Chronic renal failure is a disease characterized by decreased kidney function andtherefore a change in haematological parameters in cats. In our work we analyzed the hematologicalparameters, course of renal disease and the lifespan of cats suffering from chronic renalinsufficiency. The aim of the study was to compare the haematological parameters of cats sufferingfrom CRF, fed a renal diet; cats suffering from CRF not fed a renal diet and cats that were completelyhealthy. Then, the importance of using CRF-approved food for diseased cats and the effectivenessof its application was determined.The study included a total of 60 cats, divided into three groups. The blood parameters of cats usedin our study were: erythrocytes, thrombocytes, total leucocytes, differential leukocyte, hemoglobinconcentration, hematocrit, MCV, MCH, MCHC, creatinine and urea. The study lasted for three yearsat the Veterinary Ambulance for pets "MIM COOP" Banja Luka.The study data were statistically analyzed using a T-test (p<0.05) and Pearson's correlationcoefficient. The results of our study show that the mean values of haematological parameters in thegroup of cats that did not use a renal diet for cats suffering from CRF were different statisticallyfrom other two groups of cats: the group that used a renal diet for cats suffering from CRF andcontrol groups of cats. Also, cats that used а renal diet have better quality of life and live longer thancats that did not receive this diet. Dietetic food recover kidneys of the cats suffering from CRF

IDIOPATHIC THROMBOCYTOPENIA IN DOGS - CASE REPORT

Thrombocytopenia represents a significant reduction in number of blood platelets in thecirculation of mammals. The causes of thrombocytopenia in dogs and cats are: various infectiousfactors, viruses, bacterias, parasites, various pathological conditions of the liver, spleen, bonemarrow or autoimmune diseases. Sometimes, thrombocytopenia causes many different factors orthe real cause can not be detected, and its origin is called idiopathic. In our practice, in the course ofhaematological analysis of blood, we encounter a reduced number of platelets in the blood of dogsand cats. Then we are facing the great challenge of diagnosing and treating possible idiopathicthrombocytopenia in animals.In our case, we have a Miniature poodle whose problems began at the age of 2.5. The dog had thefollowing symptoms: inapetency, somnolence, temperature of 38.80C, pale oral mucosa withpetechiae and behavioral changes. After the first hematological blood tests were performed, theresults of the parameters indicated thrombocytopenia in this dog. Diagnosis of the disease issupported by symptoms and differential diagnosis, so we started with frequent monitoring ofhaematological parameters.We included adequate therapy with the first symptoms of the disease in our case of idiopathicthrombocytopenia in a young dog. The therapy was successful, hematological parameters and thequality of life improved, and the dog is now eight years old. The treatment of idiopathicthrombocytopenia is a challenge for every small animal veterinarian and for this reason in this paperwe share our experiences with colleagues

Understanding the Male Perspective: Evaluating Quality of Life and Psychological Distress in Serbian Men Undergoing Infertility Treatment

The experience of an infertility diagnosis and treatment imposes a profound burden on affected individuals, encompassing not only physical and medical aspects but also a plethora of psychological, social, and emotional factors. By employing a multimodal assessment featuring validated self-report questionnaires, physical measurements, and clinical records, the present study aimed to explore the quality of life and psycho-emotional distress of men undergoing infertility treatment in Serbia, thereby addressing the dearth of research on the underrepresented male perspective in this domain. Findings revealed diverse semen abnormalities among participants (n = 96, average age 37.69 ± 5.72), with significant associations between longer treatment durations and reduced sperm motility. The observed rates of men surpassing predetermined DASS-42 questionnaire thresholds for depression, anxiety, and stress in the analyzed cohort were 13.54%, 11.46%, and 22.92%, respectively. Summary scores in conceptual areas comprised in the SF-36 questionnaire ranged from 49.00 ± 6.25 for the mental health dimension to 90.16 ± 17.75 obtained in the physical functioning subscale. Patients with a longer treatment duration demonstrated lower scores in the role emotional domain, indicative of a less favorable emotional state. Expectedly, inverse correlations were found between the SF-36 mental health score and DASS-42 subscales. By addressing the existing knowledge gap and highlighting the unique needs of infertile men, the finding of this study may contribute to a more inclusive and holistic approach to infertility research and management

Comprehensive Evaluation of Quality of Life in Penile Cancer Patients following Surgical Treatment

Background: Penile cancer (PC) is a highly aggressive disease, with a significant tendency for lymphatic spreading and subsequent development of distant metastases. The mutilating nature of PC surgical treatment has profound implications on the patient’s body integrity and self-image, sexual life and intimacy, voiding and mental health. The aim of our study was to comprehensively evaluate PC patients’ post-treatment quality of life (QoL), sexual activity, self-esteem, fatigue and fear of disease recurrence. (2) Methods: A cross-sectional study was conducted at the Clinic of Urology, University Clinical Centre of Serbia, and included 31 PC patients. Data were collected by means of a questionnaire. (3) Results: The average score on the Global health status scale was 67.2 out of 100 (ranging from 16.7 to 100), and the SD was 22.5. Hierarchical linear regression analysis showed that demographic characteristics, Hospital Anxiety and Depression scale (HADS) anxiety and depression scores, total Multidimensional Fatigue Inventory, Fear of cancer recurrence and Rosenberg scores and erectile function score explained a total of 78.2% of the variance in the global health status/QoL scale of PC patients. (4) Conclusions: Efforts should be made not only to increase the survival of PC patients after surgical treatment but also to enable the best possible level of QoL in the post-operative period

Papilarni karcinom jajnika kuje japanske akite sa implantacionim metastazama kao posljedica sindroma zaostalog jajnika – prikaz slučaja

Тумори јајника представљају ријетке неоплазме паса који се јављају код 6.25% интактних куја и хистогенетски се дијеле на туморе површинског епитела јајника, туморе герминативног епитела и стромалне туморе полне врпце. Синдром заосталог јајника представља патолошки поремећај који се јавља када послије стерилизације у тијелу кује заостане дио јајника, који је хормонално активан, тј. најчешће продукује естроген. У овом приказу случаја описан је папиларни карцином јајника стерилисане кује јапанске аките, старости 11 година. Клинички куја је показивала знаке агресије, дистензију и болност абдомена, бјеличаст вагинални исцједак и билатералну алопецију. Параметри крвне слике, биохемије крви и кортизол су били у референтним вриједностима. Ултразвучним прегледом абдомена уочена је ехогена формација величине 12×9 cm, са анехогеним пољима, у десном квадранту, која је топографскоанатомски одговарала локализацији десног јајника. Палпацијом вулве примјећена је туморска маса, овалног облика, величине 3×4 cm. Експлоративном лапаротомијом, на локацији десног јајника уочена је туморска маса, неправилног облика, гранулисане површине. Тумор је био меко-еластичне конзистенције, величине 12×9 cm, изразито прокврљен. Мултипле дисеминоване неопластичне формације су биле локализоване на серози цријева и патрљку материце. У абдоминалној шупљини је констатовано 70 ml бистре, серозне, црвенкасте течности. Туморска маса је хируршки уклоњена и на пресјеку је била цистичног изгледа. Тумор, неколико мањих тумора са перитонеума и тумор вулве узроковани су за хистопатолошки преглед. Хистопатолошки је потврђен папиларни карцином јајника који се карактерисао умноженим полиморфним колумнарним ћелијама површинског епитела (са умјереним бројем митоза) сложених на врпцама строме по арбориформном шаблону. На вулви је утврђен лејомиом. Након одстрањивања тумора, дошло је до регресије клиничких симптома. На основу анамнестичких, клиничких, макроскопских и хистопатолошких налаза, може се закључити да је ријеч о папиларном карциному јајника са трансцеломским имплантационим метастазама. Неоплазма је била хормонски активна и покренула је синдром заосталог јајника са пратећим клиничким манифестацијама.Ovarian tumours are rare neoplasms of dogs that occur in 6.25% of intact bitches and are histogenetically divided into epithelial cell tumours, germ cell tumours and sex-cord stromal tumours. Ovarian remnant syndrome is a pathological disorder that occurs when, after sterilisation, the part of the ovary that is hormonally active remains in the bitch’s body, i.e. commonly produces estrogen. This case report describes a ovarian papillary carcinomas of sterilised Japanese Akita bitch, 11 years old. Clinically, the bitch showed signs of aggression, distension and abdominal pain, whitish vaginal discharge and bilateral alopecia. Blood count, biochemistry and cortisol parameters were in the reference values. Ultrasound examination of the abdomen revealed an echogenic formation measuring 12×9 cm, with anechoic fields in the right quadrant, with topographically and anatomically corresponded to the localization of the right ovary. Palpation of the vulva revealed a tumour mass, oval shaped, measuring 3×4 cm. By exploratory laparotomy a tumour mass was observed at the location of the right ovary, irregulary shaped, with granular surface. The tumour was soft to elastic in consistency, 12×9 cm sized, markedly bloody. Multiple disseminated neoplastic formations localised on intestinal serosa and uterine stump. In the abdominal cavity was 70 ml clear, serous, reddish fluid. The tumour was surgically removed, and had a cystic appearance in cross-section. Tumour mass, several peritoneal tumours, and vulvar mass were sampled for histopathological examination. Histopathologically, it was determined ovarian papillary carcinoma characterized by multiplied polymorphic columnar cells of the superficial epithelium (with a moderate number of mitoses) stacked on stroma bands, according to an arboriform pattern. Leiomyoma confirmed in the vulva. After removal of the tumour, there was a regression of the clinical symptoms. Based on anamnestic, clinical, macroscopic and histopathological findings, it can be concluded that it is ovarian papillary carcinoma with transcelomic implantation metastases in the peritoneum. The neoplasm was hormonally active and triggered ovarian remnant syndrome with accompanying clinical manifestations.Zbornik radova i kratkih sadržaj

Contemporary economic and business issues

This research monograph consists of 17 papers under the framework of contemporary economic and business issues which we can structure into several main research fields. These fields relate to the regulation of economic and business activities, especially in the context of digitalization processes, fiscal and monetary issues, dealing with the impact of digitalization and COVID19 pandemics on traditional academic and business debates, as well as on innovation processes in both government and the corporate sector. We can borrow the phrase from one of our papers and confirm that the papers presented show that the innovative market and digital society, as the new global development and technology paradigm of the modern world, together with its capabilities and standards, has changed the character of entrepreneurship and the state/government in terms of their new interactions. Thus, the contributions from the research monograph are made more urgent by the main objective of introspection of the traditional economic and business sectors and activities under the prism of digital transformation. The researchers were particularly interested in the impact of the COVID19 pandemic on the economic and business sectors. Although the conference was held in the midst of the pandemics, researchers were able to present valuable studies showing the extent of the threat posed by COVID 19 to the public health and economic outcomes of EU citizens. Significant pressure was placed on member state spending, particularly in countries with lower fiscal capacity, resulting in a severe temporary deterioration in the fiscal deficit and public debt. It is also noted that the crisis COVID -19 will have an uneven impact on member states and could deepen their divergence. Therefore, new and creative fiscal policies to support investment in digital transformation, green transition and innovation are of utmost importance. This monograph provides some guidance