Promising Water Management Strategies for Arid and Semiarid Environments

Water is the most limiting factor for crop production in arid and semiarid areas. The search of promising water management strategies is foremost for achieving highly productive and sustainable agriculture. Irrigation water management, water conservation, and nonconventional water use for agriculture are key issues to be considered by the National Agricultural Research Systems (NARS) in these areas. According to climate change scenarios and population growth predictions, these countries will undergo even severe water scarcity levels. Failure of resolving food production challenge will exacerbate tensions between countries, wars, and illegal immigration and compromise human, social, economic, and sustainable development in these areas. However, the search for innovative solutions to water scarcity must comply with societal values, environmental sustainability, and market growth

Multiplexed affinity measurements of extracellular vesicles binding kinetics.

Extracellular vesicles (EVs) have attracted significant attention as impactful diagnostic biomarkers, since their properties are closely related to specific clinical conditions. However, designing experiments that involve EVs phenotyping is usually highly challenging and time-consuming, due to laborious optimization steps that require very long or even overnight incubation durations. In this work, we demonstrate label-free, real-time detection, and phenotyping of extracellular vesicles binding to a multiplexed surface. With the ability for label-free kinetic binding measurements using the Interferometric Reflectance Imaging Sensor (IRIS) in a microfluidic chamber, we successfully optimize the capture reaction by tuning various assay conditions (incubation time, flow conditions, surface probe density, and specificity). A single (less than 1 h) experiment allows for characterization of binding affinities of the EVs to multiplexed probes. We demonstrate kinetic characterization of 18 different probe conditions, namely three different antibodies, each spotted at six different concentrations, simultaneously. The affinity characterization is then analyzed through a model that considers the complexity of multivalent binding of large structures to a carpet of probes and therefore introduces a combination of fast and slow association and dissociation parameters. Additionally, our results confirm higher affinity of EVs to aCD81 with respect to aCD9 and aCD63. Single-vesicle imaging measurements corroborate our findings, as well as confirming the EVs nature of the captured particles through fluorescence staining of the EVs membrane and cargo.Ignition Program - Boston University; INDEX (766466) - Horizon 2020; iCorps (2027109) - National Science Foundation; PFI-TT (1941195) - National Science FoundationPublished versio

Optical Determination of Electron-Phonon Coupling in Carbon Nanotubes

We report on an optical method to directly measure electron-phonon coupling in carbon nanotubes by correlating the first and second harmonic of the resonant Raman excitation profile. The method is applicable to 1D and 0D systems and is not limited to materials that exhibit photoluminescence. Experimental results for electron-phonon coupling with the radial breathing mode in 5 different nanotubes show coupling strengths from 3-11 meV, depending on chirality. The results are in good agreement with the chirality and diameter dependence calculated by Goupalov et al.Comment: Corrected a mistake in the reference

Telemedicine in patients with peripheral arterial disease:is it worth the effort?

Introduction: For patients with peripheral arterial disease (PAD), the various components of telemedicine, such as telemonitoring, telecoaching, and teleconsultation, could be valuable in daily management. The objective of this review was to give an overview of the current use of telemedicine interventions in PAD. Areas covered: A literature search was performed for studies that evaluated patients with PAD of the aorto-pedal trajectory, who were monitored by telemedicine and acted upon accordingly. The primary outcome was health-related outcomes. The studies that were found focused mainly on wearable activity monitoring and telecoaching in PAD (n = 4) or wound monitoring after vascular surgery (n = 2). Main results indicate that telemedicine interventions are able to detect (post-operative) complications early, improve functional capacity and claudication onset time, and improve PAD patients’ quality of life. Expert opinion: The use of telemedicine in PAD patients is still an under-explored area. Studies investigating the use of telemedicine in PAD are very limited and show varying results. Owing to its high potential in improving physical ability, lifestyle coaching, and timely detection of deterioration, future research should focus on proper implementation of telemedicine in PAD patients, including clinical and feasibility outcomes, effect on workload of nurses, and cost-efficiency.</p

Fabrication of high-speed resonant cavity enhanced schottky photodiodes

We report the fabrication and testing of a GaAs-based high-speed resonant cavity enhanced (RCE) Schottky photodiode. The top-illuminated RCE detector is constructed by integrating a Schottky contact, a thin absorption region (In0.8Ga0.92As) and a distributed AlAs-GaAs Bragg mirror. The Schottky contact metal serves as a high-reflectivity top mirror in the RCE detector structure. The devices were fabricated by using a microwave-compatible fabrication process. The resulting spectral photo response had a resonance around 895 nm, in good agreement with our simulations. The full-width-at-half-maximum (FWHM) was 15 nm, and the enhancement factor was in excess of 6. The photodiode had an experimental setup limited temporal response of 18 ps FWHM, corresponding to a 3-dB bandwidth of 20 GHz

MESSAGEix-Materials v1.0.0: Representation of Material Flows and Stocks in an Integrated Assessment Model

Extracting and processing raw materials into products in industry is a substantial source of CO2 emissions, which currently lacks process detail in many integrated assessment models (IAMs). To broaden the space of climate change mitigation options and to include circular economy and material efficiency measures in IAM scenario analysis, we developed MESSAGEix-Materials module representing material flows and stocks within the MESSAGEix-GLOBIOM IAM framework. With the development of MESSAGEix-Materials, we provide a fully open-source model that can assess different industry decarbonization options under various climate targets for the most energy and emissions-intensive industries: Aluminium, iron and steel, cement, and petrochemicals. We illustrate the model’s operation with a baseline and mitigation (2 degrees) scenario setup and validate base year results for 2020 against historical datasets. We also discuss the industry decarbonization pathways and material stocks of the electricity generation technologies resulting from the new model features

High-speed >90% quantum-efficiency p-i-n photodiodes with a resonance wavelength adjustable in the 795-835 nm range

We report GaAs/AlGaAs-based high-speed, high-efficiency, resonant cavity enhanced p-i-n photodiodes. The devices were fabricated by using a microwave-compatible fabrication process. By using a postprocess recess etch, we tuned the resonance wavelength from 835 to 795 nm while keeping the peak efficiencies above 90%. The maximum quantum efficiency was 92% at a resonance wavelength of 823 nm. The photodiode had an experimental setup-limited temporal response of 12 ps. When the system response is deconvolved, the 3 dB bandwidth corresponds to 50 GHz, which is in good agreement with our theoretical calculations. © 1999 American Institute of Physics