Inhibited spontenaous emission of perylene dye molecules embedded in nano-cavities

Abstract:{|}The radiative properties of molecules placed in cavities differ fundamentally from the radiative properties in free space. Fluorescence lifetime measurements of perylene dye molecules in polymer nanocavities are experimentally studied using time-correlated single photon counting techniques. The fluorescence lifetime of perylene is measured to be 4.8 ns. Perylene is embedded into polyacrylonitrile nanofibers and polymethylmethacrylate films. Spontaneous emission rate of perylene is inhibited by a factor of up to 2.6. Thus, the enhancement of fluorescence lifetime of perylene from 4.8 ns to 12.36 us for polyacrylonitrile nanofibers and to 12.3 ns for polymethylmethacrylate films is observed

A Research Studying the Perspectives in University Toward European Union in Terms of Demographical Variables

Bu çalışmada; meslek yüksekokullarında eğitim alan gençlerin ülkemizin Avrupa Birliği’ne üyelik sürecine bakış açılarının belirlenmesi amaçlanmaktadır. Araştırma evreni olarak Kırklareli Üniversitesine bağlı olarak öğretim faaliyetlerini yürüten altı meslek yüksekokulunun (Pınarhisar, Lüleburgaz, Babaeski, Vize, Teknik Bilimler, Sosyal Bilimler MYO) öğrencileri belirlenmiştir. Araştırma evreninin belirlenmesinde; meslek yüksekokullarında temel bilim alanlarına giren tüm programlarda eğitimin yürütülmesi etkili olmuştur. Araştırma evrenini oluşturan öğrenci sayısı 7200’dür. Örneklem belirlemede ise devam zorunluluğu bulunan öğrenciler esası oluşturmuştur. Bu öğrencilerin sayısı 6200 civarındadır. Veri toplama sürecinde bu öğrencilerden 3124 tanesine ulaşılmıştır. Veriler SPSS 13.0 istatistik programı vasıtasıyla analize tabi tutulmuştur. Araştırma sonuçlarını şu şekilde özetlemek mümkündür. a) Meslek Yüksekokullarında eğitim alan öğrencilerin %47,6’sı Türkiye’nin Avrupa Birliği üyeliğine olumlu bakmaktadır. b) Türkiye’nin Avrupa Birliği üyeliğini sosyal temelli programlarda okuyan öğrenciler, fen temelli programlarda okuyan öğrencilere oranla daha pozitif düşünmektedirler.This study aims to determine the perspectives of undergraduate students in Turkey toward European Union membership. The research area consists of students from six vocational high schools of Kırklareli University ( Pınarhisar, Lüleburgaz, Babaeski, Vize, Technical Sciences, Social Sciences ). The factor that affects the research area is the ongoing education in all programmes including the main science areas in vocational high schools. The number of the students that constitutes the research area is 7200. In determening the sample what constitutes the main point is the students whose attendance is compulsary. The number of these students is 6200. 3124 students have been contacted in collecting data process. The datas have been analyzed via SPSS 13.0 statistic programme. It is possible to sum up the research results as follows: a) %47,6 percent of students in vocational high schools consider the membership of Turkey to European Union as positive. b) Students in social sciences programmes consider the membership of Turkey to European Union more positive than the students in applied sciences programmes

Üniversite Eğitimi Alan Öğrencilerin Avrupa Birliği Üyeliğine Bakış Açılarının Belirlenmesine Yönelik Bir Araştırma

Bu çalışmada; üniversite eğitimi alan gençlerin Türkiye’nin AB’ye üyelik sürecine bakış açıları ve üniversite eğitimi alan gençlerin AB üyeliğinden ekonomik ve özgürlükler anlamında beklentileri belirlenmeye çalışılmıştır. Araştırma evreni olarak Kırklareli Üniversitesi Pınarhisar Meslek Yüksekokulu öğrencileri belirlenmiştir. Araştırma evreninin belirlenmesinde; okulda hem sosyal hem de fen bilimlerinin alanına giren programlarda eğitimin yürütülmesi etkili olmuştur. Araştırma evrenini oluşturan öğrenci sayısı 833 tanedir. Örneklem belirlemede ise devam zorunluluğu bulunan öğrenciler esası oluşturmuştur. Bu öğrencilerin sayısı 708 tanedir. Veri toplama sürecinde bu öğrencilerden 483 tanesine ulaşılmıştır. Veriler SPSS 13.0 istatistik programı vasıtasıyla analize tabi tutulmuştur. Araştırma sonuçları şu şekilde özetlemek mümkündür. a) Pınarhisar MYO’nda eğitim alan öğrencilerin %46,6’sı Türkiye’nin AB üyeliğine sıcak bakmamaktadırlar. b) AB üyeliğini program bazında sadece turizm programı öğrencileri istemektedir. c) Öğrenciler AB üyeliğinin ülkemizin olanaklarına ve özgürlüklerine katkı sağlayacağına inanmaktadırlar.In this project, it is intended to determine the feeling of the students studying at university to EU membership process, and their expectation from EU membership process by means of economics and freedom. Students of Kırklareli Unıversıty Pinarhisar Vocational of Higher School are chosen as the examination universe. In the determination of the examination universe, the existance of both social and science courses are effective. The count of students constituting the examination universe is 833 pieces. Basically, students with attendance obligation are chosen as sample. The count of these students is 708 pieces. In the data collection stage only 483 of these students are reached.The data are analyzed by SPSS 13.0 statistical software. It is possible to summarize the result like below: a) 46,4% of the students of Pinarhisar Vocational of Higher School have pozitive look on EU membership; b) On the basis of the study programs, only students of tourism program desire the membership of EU; c) Students believe that EU membership will contribute to our country by means of facilities and liberty

A Research Determening the Perspectives of University Students in Toward European Union

Bu çalışmada; üniversite eğitimi alan gençlerin Türkiye'nin Avrupa Birliği?ne üyelik sürecine bakış açıları ve öğrencilerin Avrupa Birliği üyeliğinden ekonomik, kültürel ve ulusal anlamda beklentileri belirlenmeye çalışılmaktadır. Araştırma evreni olarak Kırklareli Üniversitesi'ne bağlı yedi meslek yüksekokulunun öğrencileri belirlenmiştir. Araştırma evreninin belirlenmesinde; meslek yüksekokullarında temel bilim alanlarına giren tüm programlarda eğitimin yürütülmesi etkili olmuştur. Araştırma evrenini oluşturan öğrenci sayısı 7500 kişidir. Örneklem belirlemede esası ise devam zorunluluğu bulunan öğrenciler oluşturmuştur. Bu öğrencilerin sayısı 6500 civarındadır. Veri toplama sürecinde bu öğrencilerin 3400 tanesine ulaşılmıştır. Veriler SPSS 13.0 istatistik programı vasıtasıyla analize tabi tutulmuştur.This study aims to determine the perspectives and expectations in terms economical, cultural and national sense of undergraduate students in Turkey toward European Union membership. The research area consists of students from seven vocational colleges of Kırklareli University. The factor that affects the research area is the ongoing education in all programmes including the fundemental science areas in vocational colleges. The number of the students that constitutes the research area is 7500. In determening the sample what constitutes the main point is the students whose attendance is compulsary. The number of these students is 6500. 3400 students have been contacted in collecting data process. The datas have been analyzed via SPSS 13.0 statistic programme

Atezolizumab combined with chemotherapy in the first-line treatment of extensive-stage small cell lung cancer: A real-life data of the Turkish Oncology Group

Purpose Atezolizumab has been shown to be effective and safe in randomized trial in the first-line treatment of extensive-stage small cell lung cancer (SCLC). However, there are limited real-life data on atezolizumab. In this study, we aimed to determine the real-life efficacy and safety of atezolizumab combined with chemotherapy in the first-line treatment of extensive-stage SCLC. Methods This trial is a retrospective multicenter study of the Turkish Oncology Group, which included extensive-stage SCLC patients who received atezolizumab combined with chemotherapy in a first-line treatment. The characteristics of the patients, treatment and response rates, and PFS and OS are presented. Factors associated with PFS and OS were analyzed by univariate and multivariate analysis. Results A total of 213 patients at the 30 oncology centers were included. The median number of chemotherapy cycle was 5 (1-8) and atezolizumab cycle was 7 (1-32). After median 11.9 months of follow-up, median PFS and OS was 6.8 months (95%CI 5.7-7.8), and 11.9 months (95%CI 11-12.7), respectively. The ORR was 61.9%. ECOG-PS (p = 0.002) and number of metastatic sites (p = 0.001) were associated with PFS and pack-year of smoking (p = 0.05), while ECOG-PS (p = 0.03) and number of metastatic sites (p = 0.001) were associated with OS. Hematological side effects were common and toxicities were manageable. Conclusion This real-life data confirm the efficacy and safety of atezolizumab in combination with chemotherapy in first-line treatment of extensive-stage SCLC

Real-world data on efficacy and safety of first-line alectinib treatment in advanced-stage, ALK-positive non-small-cell lung cancer patients: A Turkish Oncology Group study

Aims: In this multicenter study, the authors aimed to determine the real-life efficacy and safety of first-line alectinib. Materials & methods: This retrospective trial included advanced-stage, ALK-positive non-small-cell lung cancer patients who were treated with first-line alectinib in terms of ALK-tyrosine kinase inhibitors, regardless of previous chemotherapy. The co-primary end points were progression-free survival both for all patients and for the treatment-naive population. The secondary end points were overall response rate, overall survival, rate of CNS progression and safety. Results & conclusion: A total of 274 patients (n = 177 for treatment-naive patients) were enrolled in the study. The median progression-free survival was 26 and 28.8 months for all patients and the treatment-naive group, respectively. The overall response rate, CNS progression rate and 1-year overall survival ratio were 77.9, 12.4 and 77%. Alectinib is a highly effective therapy with a favorable safety profile

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)