Drug-Induced Acneiform Eruptions

Acne vulgaris is a chronic skin disease that develops as a result of inflammation of the pilosebaceous unit and its clinical course is accompanied by comedones, papules, pustules, and nodules. A different group of disease, which is clinically similar to acne vulgaris but with a different etiopathogenesis, is called “acneiform eruptions.” In clinical practice, acneiform eruptions are generally the answer of the question “What is it if it is not an acne?” Although there are many subgroups of acneiform eruptions, drugs are common cause of acneiform eruptions, and this clinical picture is called “drug-induced acneiform eruptions.” There are many drugs related to drug-induced acneiform eruptions. Discontinuation of the responsible drug is generally sufficient in treatment

Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris

Ertas, Ragip/0000-0002-9269-2619WOS: 000430876600011Objective: We aimed to investigate the effect of isotretinoin treatment on sleep and quality of life in patients with AV. Methods: 109 total patients who identified as 66 AV patients attended the dermatology outpatient clinic and started isotretinoin treatment, and 43 healthy controls, were enrolled in the study. Pittsburgh Sleep Quality Index (PSQI), short form-36 (SF-36), and Global Acne Grading System (GAGS) were administered to all patients twice; before and two months after the treatment. The results were compared with the healthy control group. Results: The pretreatment physical health scores of the patients were significantly higher than the healthy controls. No significant differences were observed between before-after isotretinoin treatment regarding physical and mental health scores in AV patients. While there were no significant differences between the pretreatment and healthy control group in terms of total PSQI scores; the scores of sleep duration were significantly lower in the pretreatment group. No significant differences were observed between before-after isotretinoin treatment regarding total PSQI and subcomponent scores in AV patients. There was a statistically significant negative correlation between pre- and post-treatment total PSQI scores and physical, mental health scores in patients with AV. Conclusion: Results of the present study suggest that isotretinoin therapy does not affect the sleep quality in patients with AV. The impairment of sleep quality negatively affects the quality of life in patients with AV. More comprehensive studies assessing the effect of isotretinoin treatment on sleep quality are needed

Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study

Uzuncakmak, Tugba Kevser Ustunbas/0000-0001-8057-3463WOS: 000434665900005PubMed: 30374476OBJECTIVE: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group. METHODS: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. The number of diabetic obese patients was 138 (30%), whereas that of nondiabetic obese patients was 312 (70%). A detailed dermatological examination was performed for each case, and accompanying dermatoses were compared. RESULTS: The mean body mass index (BMI) in the obese patients and control group was 37.22 kg/m(2) and 22.23 kg/m(2), respectively. The most common dermatoses in the obese patients were, according to their frequency: striae distensae (291 patients, 64.7%), acrochordon (236 patients, 52.4%), acanthosis nigricans (213 patients, 47.3%), plantar hyperkeratosis (209 patients, 46.4%), and venous insufficiency (202 patients, 44.9%). Although hirsutism was more frequently observed in the nondiabetic obese group than in the diabetic obese group, stasis dermatitis was less frequently observed (p<0.05). CONCLUSION: We found that many dermatoses are more frequently observed in the obese patients than in the controls. We observed that the effect of obesity on skin is different from that of diabetes mellitus and that cutaneous manifestations of obesity occur more frequently. More extensive, comprehensive, and advanced studies on this subject are required

Endothelial Nitric Oxide Synthase Gene Polymorphisms (Promoter-786T/C, Exon 894 G/T and Intron G10T) in Unexplained Female Infertility

WOS: 000332502000004PubMed: 24504178Background/Aims: Recent investigations in both males and females show that there may also be some genetic risk factors associated with infertility, and endothelial nitric oxide synthase (eNOS) has important functions in implantation. We aimed to investigate the association of three different polymorphisms of eNOS (promoter -786T/C, exon 894 G/T and intron G10T) with unexplained female infertility. Materials and Methods: Two groups of patients were included in the study: (1) women with unexplained infertility and (2) healthy, fertile women with normal menstrual cycles. eNOS polymorphisms were studied in genomic DNA of each patient by polynnerase chain reaction-restriction fragment length polymorphism method. Results: Forty-one women with unexplained infertility and 40 fertile women were included. Baseline physical characteristics and hormonal parameters of the two groups were similar. For eNOS exon 894 G/T polymorphism, the GG honnozygotes were significantly lower and the heterozygotes GT were significantly higher in the infertile group than in the control group (p 0.05). Conclusion: Altered eNOS protein caused by eNOS exon 894 G/T polymorphism might cause implantation failure, which may be a possible cause of unexplained female infertility. (C) 2014 S. Karger AG, Base

Nineteen-year retrospective evaluation of pemphigus in a single dermatology centre in Istanbul, Turkey

WOS: 000519592400024Introduction: Pemphigus is an autoimmune intra-epidermal bullous disease of the skin and mucosae. Aim: To retrospectively evaluate the course, prognosis and clinical features of pemphigus. Material and methods: The files of 196 pemphigus patients admitted to our clinic between December 1995 and December 2014 were collected and analysed. Results: The male to female ratio among patients was 1 : 1.88. Pemphigus vulgaris (PV) was the most common clinical variant observed in 175 (89.3%) of the patients, followed by pemphigus foliaceus (PF) in 14 (7.1%) of the patients. The mean patient age at disease onset was 50 years. PV presented itself as skin lesions in 55 (31.4%) of the patients and as oral mucosa lesions in 120 (68.6%) of the patients. Complete remission and treatment withdrawal were obtained in 112 (57.1%) of the patients, for a mean period of 2.91 +/- 2.66 years (range: 4 months to 13 years). The mortality rate was 6%, and relapse occurred in 16 (14.3%) of the patients for a mean relapse period of 2.15 +/- 1.88 years (range: 6 months to 7 years). Mucocutaneous pemphigus (MCP) was the major clinical pattern observed in 96 (49%) of the patients. Conclusions: Within our study population, pemphigus predominately affected females, and the most common clinical variant was PV, a subtype that frequently occurs in middle-aged individuals. MCP was the most common clinical pattern. Although MCP and higher doses of corticosteroids were needed to control pemphigus, they did not seem to influence the prognosis

Results of Skin Prick Tests in Dermatology Outpatient Allergy Unit

WOS: 000518456300009Amaç: Deri prick testi (DPT) başlıca atopik dermatit (AD), kronik ürtiker (KÜ), alerjik astma (AA), ve alerjik rinit (AR) gibi hastalıkların tanı ve takibinde kullanılmaktadır. Bu çalışmanın amacı, Dermatoloji Kliniği Alerji Ünitesi (DKAÜ)'nde yapılan DPT sonuçlarının geriye dönük olarak incelenerek, endikasyonları ve pozitiflik oranlarının araştırılmasıdır. Gereç ve Yöntem: DKAÜ arşivi kullanılarak 2014-2016 yıllarında yapılan DPT sonuçları incelenmiştir. DPT sonuçları, her hasta için ayrıca arşivlenen DPT formları okunarak yapılmıştır. Bulgular: DKAÜ'nde 2014-2016 yılları arasında 1916 hastaya DPT yapılmıştır. Bu hastaların 941'inde AA, 133'ünde AR, 842'sinde dermatolojik hastalık olduğu görülmüştür. En az bir ve birden fazla alerjen madde ile DPT pozitiflik oranı, sırasıyla AA, AR ve dermatolojik hastalıklarda; %92.1, %71.4 ve %50 olarak saptanmıştır. Dermatolojik hastalıklar incelendiğinde, 69 kronik ürtiker (KÜ), 55 atopik dermatit (AD) hastası haricinde, geriye kalan 718 hastada, başlıca dermatit, idiopatik generalize pruritus (İGP) olmak üzere farklı dermatolojik hastalıkların olduğu görülmüştür. DPT pozitifliği KÜ’de %55.1, AD’te %52.7 ve diğer dermatolojik hastalıklarda %48.6 olarak saptanmıştır. Sonuç: Bu çalışmanın sonuçlarına göre DPT pozitiflik oranı, AR ve AA hastalarında hem KÜ ve AD hem de diğer dermatolojik hastalıklara göre daha yüksektir. Bunun nedeni, KÜ ve AD etyopatogenezinde tip 1 aşırı duyarlılık reaksiyonlarının rolünün daha az olması ve/veya farklı dermatolojik tanılarla yönlendirilen hastalarda doğru olmayan DPT endikasyonları olabilirObjective: Skin prick test (SPT) is mainly used for diagnosis and follow-up of diseases like atopic dermatitis (AD), chronic urticaria (CU), allergic asthma (AA) and allegic rhinitis (AR). The aim of current study is to explore the results of SPT retrospectively which were performed in Dermatology Outpatient Allergy Unit (DOAU) for identifying indications and positivity. Methods: Results of SPT which were performed on 2014-2016 were investigated based on archives of DOAU. Results of SPT were analyzed from the SPT Forms which were prepared for each patient. Results: SPT were performed on 1916 individuals who admitted to DOAU during 2015-2016. AA was determined in 941, AR in 133 and dermatological diseases were 842 patients. SPT positive results, for at least one or more allergen agents, of patients with AA, AR and dermatological diseases were 92.1%, 71.4% and 50% respectively. Dermatological diseases included; except CU in 69 patients and AD in 55 patients. In the remaining 718 patients were diagnosed with dermatitis, idiopathic generalised pruritus (IGP) and other dermatological disorders. SPT positivity rates in CU was 55.1%, 52.7% in AD and 48.6% in several dermatological diseases. Conclusions: As a result, the rate of SPT positivity in patients with AA and AR were higher than both CU, AD and several dermatological diseases. The reason of this may be related with lesser role of type 1 hypersensivity reaction in etiopathogenesis of CU and AD, and/or improper SPT indications who were directed with diagnosis of several dermatological diseases

Morphea secondary to interferon betai B injection: A case and review of the literature

PubMed ID: 31046913Interferon beta (IFNß) is a drug used successfully in the treatment of multiple sclerosis (MS). Although IFNß is a safe and well-tolerated drug, dermatological side effects are common. The most common dermatological adverse effect is a local reaction at the injection site. It may also cause inflammatory and immune-mediated dermatological side effects. However, morphea induced by IFNßlb injection is very rare. © 2019, Dermatology Online Journal. All rights reserved

A psoralen and ultraviolet A-aggravated dermatosis: Grover's disease

WOS: 000519583900006Grover's disease (GD) is an acquired dermatosis called transient acantholytic dermatosis. The exact cause is unknown, but the factors blamed for the etiology include ultraviolet (UV), sweating, temperature rise, radiation, medications, and malignancies. Topical corticosteroids, topical retinoids, and topical calcipotriol are usually sufficient for treatment, and systemic retinoids, systemic steroids, phototherapy, and methotrexate are rarely used. The current report describes the case of GD in a female patient, which was aggravated by the psoralen and UVA phototherapy

Case Report: Nicolau syndrome due to etofenamate injection

Nicolau syndrome, also known as embolia cutis medicomentosa, is a rare complication characterized by tissue necrosis that occurs after injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery and cytotoxic effects of the drug. Severe pain in the immediate postinjection period and purplish discoloration of the skin with reticulate pigmentary pattern is characteristic of this syndrome. Diagnosis is mainly clinical and there is no standard treatment for the disease. Etofenamate is a non-steroidal anti-inflammatory drug and a non-selective cyclooxygenase inhibitor. Cutaneous adverse findings caused by etofenamate are uncommon. Herein, we present a case with diagnosis of Nicolau syndrome due to etofenamate injection, which is a rare occurrence. © 2017 Ozlu E et al