The Relationship Between Physical Activity and Life Satisfaction: The Mediating Role of Social-Physique Anxiety and Self-Esteem

The primary aim of the study was to investigate the relationship between physical activity, life satisfaction, and the mediating effects of social-physique anxiety and self-esteem. Furthermore, this study assessed the measurement invariance of research models according to gender and age. A total of 334 participants (29.43 ± 8.17 years) completed the measures. Path analysis was utilized to appraise the research models. The research models exhibited excellent fit based on the data fit index values. The findings of the study showed a positive relationship between physical activity and both self-esteem and life satisfaction. In contrast, a negative relationship was observed between social-physique anxiety and physical activity. Social-physique anxiety was negatively related to self-esteem and life satisfaction. Furthermore, social-physique anxiety played a mediating role in the correlation between physical activity and life satisfaction. Additionally, self-esteem was a mediator in the relationship between social-physique anxiety and life satisfaction. Physical activity directly and indirectly positively impacted life satisfaction, mediated by social-physique anxiety and self-esteem. Eventually, the finding highlights physical activity's significance in mitigating social-physique anxiety and promoting self-esteem and life satisfaction. Hence, promoting physical activity can yield positive outcomes for both physical and psychological well-being, contributing to an overall improvement in quality of life. Encouraging regular physical activity can be incorporated into public health campaigns and wellness programs, as well as in individualized health plans

The thiol/disulfide balance in ketone positive and ketone negative pregnant women with nausea and vomiting — a prospective study in a tertiary center

Objectives: We aimed to investigate the thiol/disulfide balance in ketone positive (hyperemesis gravidarum) and ketonenegative pregnant women with nausea and vomiting.Material and methods: A total of 60 patients under the 14th week of pregnancy were included in this study, and they weredivided into two groups. Group 1 included 30 pregnant women with ketone positive, group 2 included 30 ketone negativepregnant women with nausea, and vomiting.Results: The native thiol, disulfide, and total thiol concentrations were measured using an automated method and comparedamong the two groups. There were also three indexes that are derived from disulfide, native and total thiol (Index1 = 100 × disulfide/native thiol); (Index 2 = 100 × disulfide/total thiol); (Index 3 = 100 × native thiol/total thiol). Whencompared with Group 1 and Group 2, total thiol was high, native thiol was low but not statistically significant. Disulphide(p = 0.046), index 1 (p = 0.036) and index 3 (p = 0.034) were statistically significant.Conclusions: Patients with ketone positive are shifting to OS direction due to lack of nutrients and electrolytes. This studyemphasizes the therapeutic potential of antioxidant supplementation, which is becoming an increasingly used approachin treating the symptoms of women with ketone positive

Ghrelin does not change in hyperemesis gravidarum

Objectives: Ghrelin levels can play an important role in maintaining the energy balance of pregnant women. Therefore,we investigated the relationship between HG and Ghrelin.Material and methods: 50 female patients admitted to the VAN Yüzüncü Yıl University, Gynecology and Obstetrics Departmentwere evaluated. The patients were divided into two groups: Group 1 included 25 pregnant women with HG, Group 2included 25 healthy pregnant women.Results: The two groups showed similarities in terms of age, gravidity, B-HCG and gestational age. There was no statisticallysignificant difference between the two groups in terms of the Ghrelin levels (p = 0.867).Conclusions: This study shows that there is no difference between Ghrelin levels and HG during pregnancy. IncreasedGhrelin in previous studies was attributed to low oral intake. Another study reported lower Ghrelin levels are not the resultof, but are rather the cause of, reduced oral intake during. The balancing of these two conditions does not lead to a changein the level of Ghrelin

Radiological Findings of Hepatic Epithelioid Hemangioendothelioma: A Rare Case Report

Hepatik epiteloid hemanjioendotelyoma, klinik seyri öngörülemeyen, nadir görülen, düşük dereceli, vasküler bir tümördür ve genellikle radyolojik karakteristik özelliklere dayanarak diğer karaciğer tümörleri gibi yanlış teşhis edilir. En yaygın tutulum bölgeleri karaciğer, akciğer ve kemiktir. Genellikle asemptomatik seyirli olması ve diğer hepatik malignitelere kıyasla daha nadir görülmesi nedeniyle bu tümörün teşhisinde hala zorluklar bulunmaktadır. Bu hastalığın erken teşhisinde radyolojik görüntüleme yardımcı olabilir. Bu olguda ayırıcı tanıyı genişletmek ve doğru tanı koymak için olası akciğer metastazlı hepatik epiteloid hemanjioendotelyomanın görüntüleme bulgularını sunmayı amaçladık. Sağ üst kadran ağrısı olan 38 yaşında bir kadın hastayı bilgisayarlı tomografi (BT), manyetik rezonans görüntüleme (MRG) ve pozitron emisyon tomografisi (PET-BT) görüntüleme modaliteleri ile değerlendirdik. Kesin tanı lezyonun biyopsisi sonrasında histopatolojik değerlendirme sonrasında konuldu

Analysis of the process leading to termination of pregnancy in the third trimester

Objective: To evaluate fetal anomalies and processes leading to termination of pregnancy in the third trimester. Methods: The study includes all cases who underwent termination of pregnancy after 28 weeks of gestation due to fetal anomalies between 2017 and 2022. Results: Forty four of third trimester terminations were carried out in our clinic due to fetal anomalies incompatible with life or associated with severe sequelae. Structural anomalies including 35 (79.5%) cases were the most common reason of terminations followed by chromosomal or genetic abnormalities in 8 (18.2%) cases and intrauterine cytomegalovirus infection in 1 (2.3%) case. The processes leading to the third trimester termination were evaluated by dividing 44 patients into 5 groups. (1) Delayed diagnosis due to inadequate prenatal care (25 patients, 56.8%); (2) patients diagnosed with late-onset findings (5 patients, 11.4%); (3) patients with abnormal findings in prenatal care or history but delayed diagnosis (5 patients, 11.4%); (4) patients with abnormal findings requiring further evaluation (4 patients, 9.0%); (5) patients with a definitive diagnosis but latency in the decision of family for termination of pregnancy (5 patients, 11.4%). Conclusion: Termination of pregnancy in the third trimester has an important role in countries where unfollowed pregnancies are common and access to health services is poor due to low socio-economic status

Datura Stramonium Intoxication: Report of a Case with Psychiatric Symptoms

ABSTRACT Datura stramonium intoxication: report of a case with psychiatric symptoms Delirium is a common neuropsychiatric syndrome and is often caused by metabolic, systemic disorders and drug or poison intoxication. Though hallucinations, delusions and agitation are sometimes present, the symptoms of delirium are clinically distinct from those induced by other psychiatric disorders. Datura stramonium is a hallucinogenic plant which is a member of belladona alkaloids. The toxic effects of Datura stramonium most often include visual and auditory hallucinations, confusion and agitation. We report a patient who was poisoned with Datura stramonium and presented to the emergency department with psychiatric symptoms. Key words: Intoxication, psychosis, delirium ÖZET Datura stramonium zehirlenmesi: Psikiyatrik belirtilerle başvuran olgu Deliryum, pek çok sistemik hastalık ve metabolizma bozukluklarının yanı sıra, ilaç ya da maddelerin toksik etkisi sonucu da oluşabilir. Hastada sanrılar, varsanılar ve ajitasyon gibi birçok psikiyatrik belirti ve bulgu tespit edilebileceğinden, sıklıkla diğer psikiyatrik bozukluklarla karışabilir. Datura stramonium belladona alkaloid ailesinin bir üye-si olan hallüsinojenik bir bitkidir ve yüksek doz alınması durumunda görsel ve işitsel hallüsinasyonlar, ajitasyon ve deliryuma sebep olabilir. Biz bu olgu sunumunda, acil servise "akut psikoz ve demans" ön tanılarıyla sevk edilen ve Datura stramonium alımına bağlı oluştuğu tespit edilen bir deliryum vakasını tartışmayı amaçladık

Orta lob sendromlu olgularda bilgisayarlı tomografi bulguları

Amaç: Orta lob sendromu OLS , sağ akciğer orta lobunun kronik veya tekrarlayan atelektazileri ile karakterize bir tablodur. Spesifik bir klinik bulgusu yoktur. OLS tanısında Bilgisayarlı Tomografi BT en sık kullanılan modalitedir. Kliniğimizde son iki yılda OLS tanısı almış hastaların BT bulgularını literatür eşliğinde sunmayı amaçladık.Gereç ve Yöntem: Mayıs 2015- Mayıs 2017 tarihleri arasında hastanemiz radyoloji kliniğine başvuran ve OLS tanısı alan 29 hastanın, BT ve klinik bulguları retrospektif olarak iki radyolog ve bir göğüs hastalıkları uzmanı tarafından incelendi. Bulgular: OLS tanısı alan 29 hastanın 17’si %58,6 kadın, 12’si %41,4 erkek hastaydı. Kadın/erkek oranı 1.42 idi. Bu olguların yaş ortalaması ise 59,4±17,01 8-84 yaş olarak hesaplandı. Klinik değerlendirmede en sık semptom öksürük, nefes darlığı ve balgam olarak saptandı. Radyolojik görüntülemede tüm hastaların BT tetkiklerinde sağ akciğer orta lobda atelektazi mevcuttu. Atelektazi ile birlikte diğer en sık eşlik eden bulgular ise 11 hastada mediastinal ve/veya hiler patolojik görünümde lenfadenopati, 6 hastada bronşektazi, 4 hastada enfeksiyon ile uyumlu parankimal bulgular, 3 hastada parankimal nodüller, 3 hastada peribronşial kalınlaşma, 2 hastada operasyon sonrası değişiklikler, 2 hastada diafragmaevantrasyonu, 2 hastada mukus tıkacı, 1 hastada squamöz hücreli kanser, 1 hastada da pulmoneremboli idi. Dört hastada herhangi bir ek akciğer patolojisi saptanmadı. Sonuç: OLS, sağ akciğer orta lobun total atelektazisi olup spesifik klinik bulguları olmaması nedeniyle kronik ve tekrarlayan akciğer şikayetleri olan her hastada özellikle sağ akciğerde yerleşim gösteren lezyonlarda ayırıcı tanılar arasında göz önünde bulundurulmalıdır. BT’nin rutine girmesi ile de radyolojik olarak görülme sıklığı artmıştır. BT, OLS tanısında etkin ve noninvaziv bir görüntüleme yöntemidi

Global water quality changes posing threat of increasing infectious diseases, a case study on malaria vector Anopheles stephensi coping with the water pollutants using age-stage, two-sex life table method

Background: Water pollution due to uncontrolled release of chemical pollutants is an important global problem. Its effect on medically important insects, especially mosquitoes, is a critical issue in the epidemiology of mosquito-borne diseases. Methods: In order to understand the effect of water pollutants on the demography of Anopheles stephensi, colonies were reared in clean, moderately and highly polluted water for three consecutive generations at 27 °C, 75% RH, and a photoperiod of 12:12 h (L:D). The demographic data of the 4th generation of An. stephensi were collected and analysed using the age-stage, two-sex life table. Results: The intrinsic rate of increase (r), finite rate of increase (λ), mean fecundity (F) and net reproductive rate (R0) of An. stephensi in clean water were 0.2568 d−1, 1.2927 d−1, 251.72 eggs, and 109.08 offspring, respectively. These values were significantly higher than those obtained in moderately polluted water (r = 0.2302 d−1, λ = 1.2589 d−1, 196.04 eggs, and R0 = 65.35 offspring) and highly polluted water (r = 0.2282 d−1, λ = 1.2564 d−1, 182.45 eggs, and R0 = 62.03 offspring). Female adult longevity in moderately polluted (9.38 days) and highly polluted water (9.88 days) were significantly shorter than those reared in clean water (12.43 days), while no significant difference in the male adult longevity was observed among treatments. Conclusions: The results of this study showed that An. stephensi can partially adapt to water pollution and this may be sufficient to extend the range of mosquito-borne diseases

Kemijski sastav te antioksidacijski, citotoksični i insekticidni potencijal valerijane Valeriana alliariifolia u Turskoj

Valeriana is a common plant species used for various healing purposes in folk medicine since antiquity. This study investigates the phytochemical profile, antioxidant, cytotoxic, and insecticidal activity of Valeriana alliariifolia Adams, a species that has traditionally been used in Turkey. For the analyses we prepared four root extracts of V. alliariifolia Adams using hexane (HM1), chloroform (CM1), ethanol (EM1), and water (WM1) for maceration. Additionally, two extracts were also prepared from its roots by maceration separately with ethanol (EM2) and water (WM2). One sample was prepared as a water infusion (WI), according to the procedure used in Turkish traditional medicine. The 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical cation scavenging activity tests showed that ethanol extracts had the strongest antioxidant activity: EM1 (IC50 – DPPH: 17.694 μg/mL; ABTS: 23.8 μg/mL) and EM2 (IC50 – DPPH: 20 μg/mL; ABTS: 21.5 μg/mL). The hexane extract, HM1, was the most cytotoxic (IC50<10 μg/mL against HepG2 and HUVEC) and EM2 strongly cytotoxic (IC50<10 μg/mL against HepG2 and IC50: 11.96 μg/mL against HUVEC). The extracts with demonstrated cytotoxic activities were further examined to check their insecticidal activity against adult female mosquito Aedes aegypti and first instar Ae. aegypti larvae. HM1 was the most effective (90±10 %), which was consistent with its cytotoxic activity. Because of the high antioxidant, cytotoxic, and insecticidal activities, we ran phytochemical analyses of the HM1, EM1, and EM2 extracts with GC-MS (for HM1) and LC-MS/MS (for EM1 and EM2). We also analysed the composition of the essential oil obtained from V. alliariifolia roots by micro-distillation in order to compare its content with HM1, which contains volatile compounds. Phytochemical analyses revealed that the major compound in HM1 was isovaleric acid (16 %) and in the essential oil 1,8-cineole (2.9 %). EM1 and EM2 contained 5-O-caffeoylquinic acid (chlorogenic acid), verbascoside (acteoside), and 3,5-dicaffeoylquinic acid as major components. In the light of our findings and available literature, we can conclude that V. alliariifolia has a good bioactive potential that could be used for different purposes, including the development of new agents for the treatment of various diseases. The difference in the content between the essential oil and HM1 was remarkable. It suggests that the variability observed in the activity of the samples was a result of composition and that, therefore, the aim of treatment should dictate which type of preparation is to be selected. An added value of our study is that it determined verbascoside and methylquercetin rutinoside for the first time in the Valeriana extracts.Valerijana (odoljen) česta je biljna vrsta koja se zbog svojih ljekovitih svojstava od davnina rabi u narodnoj medicini. U ovome se istraživanju utvrdio fitokemijski profil te antioksidacijsko, citotoksično i insekticidno djelovanje tradicionalne vrste koja se za liječenje rabi u Turskoj – Valeriana alliariifolia Adams. Za analizu je maceracijom pripremljeno šest ekstrakata njezina korijena pomoću heksana (HM1), kloroforma (CM1), etanola (EM1, EM2) i vode (WM1, WM2). Jedan je uzorak pripremljen infuzijom vodom (WI) prema tradicionalnom turskom receptu za ljekovite pripravke. Testovima antioksidacijskoga djelovanja pomoću 2,2-difenil-1-pikrilhidrazila (DPPH) i 2,2’-azino-bis(3-etilbenzotiazolin-6-sulfonične kiseline (ABTS) izdvojeni su sljedeći ekstrakti s najjačim antioksidacijskim djelovanjem: EM1 (IC50 – DPPH: 17,694 μg/mL; ABTS: 23,8 μg/mL) i EM2 (IC50 – DPPH: 20 μg/mL; ABTS: 21,5 μg/mL). Ekstrakt s heksanom, HM1, iskazao je najveću citotoksičnost (IC50<10 μg/mL protiv tumorskih stanica HepG2 i HUVEC), a EM2 snažnu citotoksičnost (IC50<10 μg/mL protiv HepG2 stanica te IC50 11,96 μg/mL protiv HUVEC stanica). Ekstrakte s najsnažnijim citotoksičnim djelovanjem također smo analizirali za insekticidno djelovanje protiv odraslih ženki komarca vrste Aedes aegypti te njihovih ličinki. U skladu sa svojom citotoksičnosti, HM1 se pokazao najdjelotvornijim (smrtnost 90±10 %). Zbog snažnog antioksidacijskog, citotoksičnog i insekticidnog djelovanja, napravili smo i fitokemijsku analizu ekstrakata HM1, EM1 i EM2 služeći se metodama GC-MS (za HM1) i LC-MS/MS (za EM1 i EM2). Također smo analizirali sastav esencijalnoga ulja dobivenoga mikrodestilacijom korijena V. alliariifolia kako bismo ga usporedili sa sastavom HM1, koji je sadržavao hlapljive sastojke. Fitokemijska je analiza pokazala da je glavni sastojak HM1 izovalerijanska kiselina (16 %), a esencijalnoga ulja 1,8-cineol (2,9 %). Glavni sastojci ekstrakata EM1 i EM2 bili su 5-O-kafeoilkvinska kiselina (klorogena kiselina), verbakozid (akteozid) i 3,5-dikafeoilkvinska kiselina. U svjetlu ovih rezultata i dostupne literature, možemo zaključiti da V. alliariifolia ima dobar bioaktivni potencijal, koji se može iskoristiti za različite svrhe poput razvoja novih tvari za liječenje bolesti. Razlika u sadržaju između esencijalnoga ulja i ekstrakta HM1 pokazala se golemom te upućuje na to da su razlike u aktivnosti između uzoraka rezultat sastava, zbog čega primjena/liječenje trebaju uvjetovati koja će se vrsta pripravka odabrati. Dodatna je vrijednost ovoga istraživanja što su se u ekstraktima valerijane prvi put otkrili verbaskozid i metilkvercetin rutinozid