Comparison of GTR, T-PRF and open-flap debridement in the treatment of intrabony defects with endo-perio lesions : a randomized controlled trial

Titanium- prepared platelet rich fibrin (T-PRF) is an autologous hemo-component with a high concentration of platelets that also incorporates leukocytes, and growth factors into the dense fibrin matrix and can be used as a healing biomaterial. This study assesses the adjunctive use of T-PRF in intrabony defects (IBDs) with open flap debridement (OFD) in comparison with guided tissue regeneration (GTR) as a gold standard and OFD alone as a control. A total of 45 patients (15 per group) were randomized as either T-PRF (test group), GTR (test group), or OFD alone (control group) sites. Probing depth (PD), clinical attachment level (CAL), and IBD were recorded. The radiographic depth of IBD was also measured. Primary outcomes assessed were changes in PD, CAL, and radiographic IBD that were assessed at the beginning and nine months later.  The PRF and GTR group showed significant improvement in clinical parameters compared with the OFD alone (control group) at nine months. While there were no significant differences in PD and CAL between test groups (T-PRF and GTR groups), the significant difference was found in radiographic IBD depth. T-PRF may give similar successful results as GTR in the treatment of IBDs with endo-perio lesions

Evaluation of salivary cortisol levels and perceived stress levels in gingivitis and periodontal healthy individuals

Amaç: Psikososyal faktörler periodontal hastalık için önemli bir risk faktörü olarak tanımlanır, konak direncini değiştirerek ve endokrin dengesizliklere neden olarak periodontal dokuları etkileyebilir. Bu çalışmada algılanan stres ve strese bağlı hormon düzeyiyle periodontal durum arasındaki ilişkinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Bu çalışmaya 42 gingivitisli ve 30 periodontal olarak sağlıklı, toplam 72 birey dahil edildi. Hastaların klinik ve radyolojik periodontal değerlendirmesi yapıldı. Stres düzeyleri tükürük kortizol seviyesi ve Cohen Algılanan Stres Ölçeği (ASÖ-10) değerleri kullanılarak incelendi. Bireylerin tükürükteki kortizol seviyesi ELİSA yöntemi kullanılarak ölçüldü. Elde edilen veriler p<0.05 anlamlılık düzeylerine göre istatistiksel olarak analiz edildi. Bulgular: Sosyodemografik veriler değerlendirildiğinde fırçalama sıklığının kontrol grubunda daha yüksek olduğu görüldü (p<0.05). Periodontal olarak sağlıklı gruptaki tükürük kortizol seviyesi ve ASÖ-10 skorları, gingivitis grubuna kıyasla daha düşüktü (p<0.05). Tükürük kortizol seviyesi ve algılanan stres ölçeği skorları ile periodontal klinik parametreler arasında pozitif korelasyon gözlendi. Sonuç: Gingivitisli bireylerde daha yüksek stres seviyesi görülmektedir. Çalışmamızın sonuçları dahilinde stres ile periodontal hastalık arasında pozitif bir ilişki olduğu söylenebilir. Bununla birlikte, stres ve periodontal hastalık arasındaki ilişkiyi açıklamak için daha ileri araştırmalara ihtiyaç vardır.Aim: Psychosocial factors are identified as animportant risk factor for periodontal disease, affectingperiodontal tissues by altering host resistance andendocrine imbalances. At present study, there wasaimed to evaluate the relationship between perceivedstress scale and stress hormone level and periodontalstatus.Material and Methods: There was included the totalof 72 individuals, 42 subjects with gingivitis and 30periodontal healthy subjects in this study. Clinical andradiological periodontal evaluation of all participantswere performed. Stress levels were assessed usingsalivary cortisol level and Cohen's Perceived StressScale (PSS-10) scores. Salivary cortisol level was measuredusing by ELISA method. The data were analyzedstatistically according to p 0.05 significant levels.Results: When the sociodemographic data werecompared, no statistical difference was found betweenthe groups (p 0.05). Salivary cortisol level and PSS10scores in periodontal healthy subjects were lowerthan subjects with gingivitis (p 0.05). There was apositive correlation between salivary cortisol level andperceived stress scale scores and periodontal clinicalparameters.Conclusion: There were higher levels of stress inindividuals with gingivitis. According to the presentstudy might mention that there is a positiverelationship between stress and periodontal disease.However, the further investigations are needed toexplain the relationship between stress andperiodontal disease