65 research outputs found
BRAF V600E mutation in papillary thyroid cancer is correlated with adverse clinicopathological features but not with iodine exposure
Introduction: BRAFV600E activating mutation is the most frequent genetic abnormality in the pathogenesis of papillary thyroid carcinoma. We aimed to evaluate the association between BRAFV600E mutation and well-established prognostic clinicopathological characteristics as well as iodine exposure.
Material and methods: From 2000 to 2012, the data of PTC patients admitted to Dr. Lutfi Kirdar Kartal Education and Research Hospital in Turkey were reviewed retrospectively. Clinicopathological parameters were collected. BRAFV600E mutation was analysed by DNA sequencing method in tumour specimens. We hypothesised that BRAFV600E mutation prevalence is positively correlated with prolonged iodine exposure and expected to be higher in the second half of the recruitment period due to the increment in time spent from the iodisation process of the table salt in our country. Thus, iodine exposure was categorised as short-term (2000–2006) and long-term (2006–2012).
Results: A total of 197 patients were accrued. The study population predominantly consisted of conventional variant. A statistically significant relationship was observed between BRAFV600E mutation presence and age (p = 0.03), conventional variant PTC (p = 0.00002), T4 stage (p = 0.002), vascular invasion (p = 0.036), thyroid capsule invasion (p < 0.00001), extrathyroidal tissue invasion (p < 0.00001), and lymph node metastasis (p < 0.00001). When categorised as long-term and short-term, iodine exposure was not statistically significantly related with BRAFV600E mutation; however, there were far more PTC cases in the long-term group (86.3% vs. 13.7%).
Conclusion: We revealed that BRAFV600E mutation is associated with adverse clinicopathological parameters. There appeared to be no relation between long-term iodine exposure and BRAFV600E.
Substance Use Characteristics and Attitudes of Students in a Faculty of Health Sciences
Amaç: Bir Sağlık Bilimleri Fakültesinde okuyan öğrencilerin madde kullanım özelliklerini ve madde kullanımı ile ilgili damgalayıcı tutumlarını belirlemektir. Yöntem: Çalışma tanımlayıcı tiptedir. Evren 1154 öğrenciden, örneklem 271 öğrenciden oluşmuştur. Veriler bilgi toplama formu ve Alkol ve Madde Bağımlılığı Damgalayıcı Tutumlar Ölçeği ile toplanmıştır. Bulgular: Öğrencilerin %79,3'ü kadın, yaş ortalaması 20,84±1,58 idi. Öğrencilerin %8,9’u sigara, %5,2’si alkol ve bir öğrenci de madde kullandığını ifade etti. Alkol ve sigara içen öğrenciler, başlama nedeni olarak en çok arkadaş ortamının etkilediğini belirttiler. Bu öğrencilerin %59,4’ü sigaraya, %64,3’ü ise alkole 17 yaş ve üzerinde başladığını belirtti. Öğrencilerin %42,4’ü madde kullanımıyla ilgili bilgilerinin yetersiz olduğunu ve üniversitede bu konuda aktiviteler yapılırsa %14,8’inin bu aktivitelere gönüllü olarak destek verebileceklerini ifade ettiler. Öğrencilerin Alkol ve Madde Bağımlılığı Damgalayıcı Tutumlar ölçek puanı ile yaş, cinsiyet ve okudukları bölüm arasında istatistiksel olarak anlamlı fark bulunmazken, sınıflar arasında istatistiksel olarak anlamlı bir fark olduğu ve sınıflar arttıkça damgalayıcı tutumların arttığı görüldü. Sonuçlar: Alkol ve sigara kullanımına başlamada öğrencilerin arkadaş ortamından etkilendikleri ve bu maddelere başlamalarının üniversite yıllarında olduğu belirlendi. Madde kullanımı ile ilgili dördüncü sınıf öğrencilerinin daha fazla damgalayıcı tutum içinde oldukları söylenebilir.Objective: The objective is to assess substance use characteristics of students attending to a Faculty of Health Sciences and their stigmatizing attitude to substance use. Methodology: The study is of descriptive type. The universe consists of 1,154 students and the sample size is 271 students. Data were collected by using the form “Scale of Stigmatizing Attitudes in Alcohol and Substance Addiction.” Findings: 79.3% of students were women and their average age was 20.84±1.58. Of responding students, 8.9% stated that they smoke, 5.2% take alcohol and 1 student said he uses substance. Students who smoke and have alcohol state that they started these as a result of their circle of friends. 59.4% of smokers and 64.3% of alcohol users started these after age 17. 42.4% of students say their information about substance use is inadequate and 14.8% say they will voluntarily support if there are activities in the university in this regard. No statistically significant relationship was found between students’ scores in Scale of Stigmatizing Attitudes in Alcohol and Substance Addiction and their ages, gender and departments they are attending to. However, grade levels in the school make statistically significant difference as stigmatizing attitudes increase as grade levels get higher. Conclusion: ıt was found that smoking and alcohol use start in university years under the influence of friends. It can be said that stigmatizing attitude to substance use is adopted more widely by senior level students
COVID-19 in pediatric patients undergoing chronic dialysis and kidney transplantation
The study aims to present the incidence of COVID-19 in pediatric patients undergoing renal replacement therapy (RRT) and to compare the severity and outcomes of the disease between the dialysis and kidney transplant (KTx) groups. This multicenter observational study was conducted between 1 April and 31 December 2020 in Istanbul. Members of the Istanbul branch of the Turkish Pediatric Nephrology Association were asked to report all confirmed cases of COVID-19 who were on RRT, as well as the number of prevalent RRT patients under the age of 20. A total of 46 confirmed cases of COVID-19 were reported from 12 centers, of which 17 were dialysis patients, and 29 were KTx recipients. Thus, the incidence rate of COVID-19 was 9.3% among dialysis patients and 9.2% among KTx recipients over a 9-month period in Istanbul. Twelve KTx recipients and three dialysis patients were asymptomatic (p = 0.12). Most of the symptomatic patients in both the dialysis and KTx groups had a mild respiratory illness. Only two patients, one in each group, experienced a severe disease course, and only one hemodialysis patient had a critical illness that required mechanical ventilation. In the entire cohort, one hemodialysis patient with multiple comorbidities died.
Conclusion: While most cases are asymptomatic or have a mild disease course, pediatric patients undergoing dialysis and a kidney transplant are at increased risk for COVID-19.
What is Known:
In adult population, both dialysis patients and kidney transplant recipients are at increased risk for severe illness of COVID-19 and have higher mortality rate.
Children with kidney transplantation are not at increased risk for COVID-19 and most have mild disease course.
Data on children on dialysis are scarce.
What is New:
Pediatric patients undergoing dialysis and kidney transplantation have an increased risk for COVID-19.
Most patients undergoing renal replacement therapy either on dialysis or transplanted develop asymptomatic or mild COVID-19 disease with a favorable outcome
COVID-19 in pediatric nephrology centers in Turkey
Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10–15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients’ susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage
Göller Yöresi'nde Doğal Olarak Yetişen Bazı Yer Örtücü Bitkilerin Belirlenmesi
Çalışma alanı(Göller Yöresi)
Türkiye’nin Batı Anadolu kesiminde yer alır. Yöre, floristik açıdan çok
zengindir. Bununla birlikte bu doğal bitkiler ekonomik amaçlı veya yer örtücü amaçlı olarak nadiren
kullanılmaktadır. Bu manada, yer örtücü bitkiler yörede ekseriyetle peyzaj
düzenlemelerde fazla dikkat çekmez. Ancak bu bitkilerin fonksiyonel ve estetik
avantajları çok fazladır. Doğal yer örtücü bitkiler çok önemli olmasına rağmen
bu konudaki bilgiler de oldukça yetersizdir. Bu çalışmada, floristik
çalışmalarla yörenin potansiyel doğal yer örtücü bitkileri ilk kez belirlendi.
Çalışma, 2000-2004 yıllarında yapıldı ve bitkilerin listesi yörenin
dağlarındaki farklı habitatlarda yapılan çalışmalarla belirlendi. Yer
örtücü bitki anlamında çalışmaya dair gözlemlerimiz ilerleyen yıllarda yeniden
gözden geçirildi ve bazı tanımlamalar yapıldı. Tarafımızdan toplanan ve genel
floristik eserler yardımıyla tarafımızdan teşhisleri yapılan iletim demetli yer örtücü
bitki örnekleri Süleyman Demirel Üniversitesi’nin(Isparta) GUL Herbaryumu’unda muhafaza edilmektedir. Yer örtücü bitkiler için
Göller Yöresi’nin dağlarında yapılan arazi gözlemleri, bitkilerin botanik ve
ekolojik özellikleri çalışmada belirlendi. Bu bitkiler alfabetik sıraya
dizilerek listelendi.
Çalışmanın sonuçlarına göre; toplam olarak 79 cins ve 28 familyaya
ait 175 takson tayin edildi. Bunlardan 44
takson Fabaceae familyasına aittir. Bu familya yer örtücü bitkiler açısından diğer
familyalardan daha çok takson ihtiva eder. Yöreden tespit edilen yer örtücü
bitki taksonlarının hayat formları ve hayat formlarına dağılım oranları
aşağıdaki gibidir: Kamafit 81 (% 46.2),
Hemikriptofit 71 (% 40.5), Terofit 12 (% 6.8), Geofit 7 (% 4.0) ve Fanerofit 4
(% 2.2). Bu taksonlardan 80’i Türkiye
endemiğidir ve endemizm oranı %
46’dır. Diğer taraftan yörenin yer örtücü bitkilerinin
bitki coğrafyası bölgelerine dağılımı ve oranları şöyledir: Mediterranean(Akdeniz) elementi 48 (% 27.0),
Irano-Turanian(İran-Turan) elementi 44 (% 25.0), Euro-Siberian(Avrupa-Sibirya)
elementi 13 (% 7.0), çok bölgeli 10 (% 6.0) ve coğfafi bölgesi bilinmeyen 60 (% 34.0).
Bazı yer örtücü bitkiler peyzaj düzenlemeleri için ilk kez belirlendi ve farklı
ortamlarda uygulanması önerildi
Association of the Relationship Between Nutritional Status and Certain Biochemical Parameters in Obese Children
The prevalence of childhood obesity is increasing globally. Adiposity is more concentrated in subcutaneous tissue in women and visceral fat tissue in men. Abdominal obesity is more commonly associated with metabolic diseases in men. The results showed that the mean BMIz scores of boys was higher than girls, but total body fat was lower than girls. Total body fat free mass, water and muscle mass were higher in boys than girls. It was determined that children aged 10-17 years consumed fatty and sugary snacks and sugary drinks at school. Food consumption containing the carbohydrate, fat, saturated fat and cholesterol were higher in boys than girls. As a result, it was thought that it would be more beneficial and reliable to use anthropometric methods showing body composition together with BMI zscore while evaluating body weight in adolescents. While nutritional counseling, it may be beneficial to consider that the energy and nutrient requirements of male adolescent individuals and their daily food consumption are higher than girls. When the results of the study are evaluated, we mention that it would be appropriate to evaluate girls more carefully in terms of iron deficiency anemia and diseases such as insulin resistance and diabetes
Isparta Yöresindeki Bazı Doğal Yerörtücü Bitkilerin Adaptasyonu ve Özellikleri
Günümüzde yerörtücü bitkiler, peyzaj amaçlı bitkisel tasarım çalışmalarında yaygın bir şekilde kullanılmaktadır. Yerörtücü bitkilerin başında, Poaceae familyasına ait çim türleri gelmektedir. Çim bitki türlerine nazaran daha fazla estetik ve işlevsel katkılar sağlayabilen, tesis ve bakım maliyeti daha az olabilen çok sayıda diğer otsu, yarı odunsu ve odunsu yerörtücü bitkiler bulunmaktadır. Isparta yöresi doğal zengin bitki potansiyeline sahip olmasına rağmen ne yazık ki yaygın bir şekilde kullanılmamakta veya bilinmemektedir. Bu nedenle özellikle yerörtücü bitkisi olabilecek doğal orjinli bitkilerin bireysel özelliklerinin tesbiti ve peyzaj amaçlı kullanılabilirliklerin araştırılması büyük önem taşımaktadır.
Bu çalışmada Isparta yöresinde yetişen bazı doğal yerörtücü bitkiler, arazi çalışmaları ile yerinden sökülmek suretiyle Süleyman Demirel Botanik Bahçesi içindeki deneme parsellerine dikildi. Toplam 15 farklı bitki türünden her biri için 27 şer adet bitki üzerinde işlemler gerçekleştirildi. Bu bitkiler üzerinde, tesisinden ilk iki yıldaki yaşama yüzdesi, bitki boyu, bitki kaplama değeri ve diğer bireysel özellikler tespit edildi. Bu türler içinde, Isparta yöresine iyi uyum sağlayabilecek ve değişik amaçlı peyzaj çalışmalarında kullanılabilecek ideal yerörtücü bitkileri “Thymus zygioides var zygioides, Pilosella hoppeana, Bolanthus minuartioides, Medicago lupulina, Ajuga chamaepitys subsp chia var. chia, Trifolium repens, Lotus corniculatus L. var. tenifolius, Helichryssum plicatum subsp plicatum, Festuca pinifolia, Primula veris L. subsp macrocalyx, Salvia tomentosa ve Vinca herbacea” şeklinde belirlendi
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