Maximum likelihood dynamic factor modeling for arbitrary N and T using SEM

Item does not contain fulltextThis article has 3 objectives that build on each other. First, we demonstrate how to obtain maximum likelihood estimates for dynamic factor models (the direct autoregressive factor score model) with arbitrary T and N by means of structural equation modeling (SEM) and compare the approach to existing methods. Second, we go beyond standard time series analysis (T large and N = 1) and conventional SEM (N large and T = 1 or small) by integrating both approaches. The resulting combined model offers a variety of new modeling options including a direct test of the ergodicity hypothesis, according to which the factorial structure of an individual observed at many time points is identical to the factorial structure of a group of individuals observed at a single point in time. Third, we illustrate the flexibility of SEM time series modeling by extending the approach to account for complex error structures. We end with a discussion of current limitations and future applications of SEM-based time series modeling for arbitrary T and N.22 p

Histopathological findings in brain tissue obtained during epilepsy surgery

Item does not contain fulltextBackground: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. Methods: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). Results: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. Conclusions: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.)9 p