Yüksek Ziraat Enstitüsü'nün kuruluş yıllarında Almanca dersleri, okutmanları ve öğretim yöntemleri

Yüksek Ziraat Enstitüsü (YZE) 1933 yılında Ankara'da Alman profesörler ile öğretime başlamıştır. Enstitü bünyesinde kurulan Yabancı Diller Semineri'nde Neumann, Lapper, Matschenz, Marchand, Ulshöfer ve Göbel gibi Almanca öğretmenleri görev almıştır. Lapper'in şarkı söyleyerek öğretmeye çalıştığı yöntem kabul görmemiştir. Ulshöfer'in Alman Dışişleri'ne gönderdiği raporlarda öğrenciler, ders kitapları ve Almanca derslerinin yöntemi hakkında bilgiler verilmiştir. Bu çalışmada Yüksek Ziraat Ensitüsü'nün kuruluş yıllarında görev yapmış olan Lapper ve Ulshöfer'in çalışmalarına dair bulunan arşiv kaynaklarına dayanarak Almanca dersleri incelenmiştir.The High Agricultural Institute (YZE) started education in Ankara in 1933 with German professors. German teachers such as Neumann, Lapper, Matschenz, Marchand, Ulshöfer and Göbel took part in the Foreign Languages Seminar established within the Institute. The method Lapper tried to teach by singing was not accepted. In the reports Ulshöfer sent to the German Foreign Office, information was given about the students, textbooks and the method of German lessons. In this study, German lessons were examined based on the archival sources found on the work of Lapper and Ulshöfer, who had served in the founding years of the Higher Institute of Agriculture

Forecasting intermittent demand using the cox process

If a demand has infrequent demand occurrences and irregular demand sizes, then it is intermittent demand. Generally, intermittent demand appears at random, with many time periods having no demand. Owing to peculiar characteristics of intermittent demand, demand forecasting for intermittent demand is especially difficult. There are ad hoc methods developed for intermittent demand forecasting. Since Cox process has shown superior performance for intermittent demand forecasting, we studied forecasting intermittent demand using Cox process in this study. We develop a new method for estimating Cox process intensity which is called Reversed Leven and Segerstedt (RLS) method. Moreover, we propose a novel method which is a Wavelet Transform and Reversed Leven and Segerstedt conjunction model for intermittent demand forecasting using Cox process. Using real data set of 500 kinds of spare parts from an aviation sector company in Turkey, we show that our method produces more accurate forecasts than other intermittent demand forecasting methods using Cox process. The comparison approach has a lead time perspective which is based on lead time ahead demand forecast and lead time demand forecast errors. © 2018 Old City Publishing, Inc

Düşük serum UCH-L1 ve TDP-43 düzeyleri otizmde bozulmuş ubikuinasyon sürecini yansıtabilir mi?

WOS: 000412669100014PubMed ID: 29033641Introduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear. We examined the association between autism and serum transactive response DNAbinding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitinproteosome system. Methods: We measured serum levels of TDP-43 and UCH-L1 in 24 children with autism and 24 healthy children. Childhood Autism Rating Scale (CARS) was used to assess symptom severity at admission. Results: The mean serum TDP-43 and UCH-L1 levels in children with autism spectrum disorder (ASD) were found to decrease compared to healthy controls (p< 0.001, 506.21 +/- 780.97 ng/L and 1245.80 +/- 996.76 ng/L, respectively; 3.08 +/- 5.44 ng/mL and 8.64 +/- 6.67 ng/mL, respectively). A positive correlation between serum TDP-43 levels and UCH-L1 levels was found in the ASD group (r= 0.947, n= 24, p< 0.001). The CARS score of children with ASD was 48.91 points (standard deviation [SD]: 5.82). Conclusion: Low serum levels of UCH-L1 and TDP-43 may reflect disturbed ubiquitination in autism.Amaç: Protein ubikitinlenme ile ilgili bozuklukların nöronal gelişim sorunlarına nasıl yol açtığı açıklanamamıştır. Bu çalışmada, ubikuitin proteozom sistemine üye olan ubikuitin c-terminal hidrolaz-L1 (UCH-L1) ve transaktif yanıtlı DNA-bağlayıcı protein (TDP-43) düzylerinin otizm ile ilişkisi araştırılmıştır.Yöntemler: Bu bağlamda 24 otizm tanılı çocuk ve 24 sağlıklı çocukta serum TDP-43 ve UCH-L1 düzeylerine bakılmıştır. Otizm şiddet derecesi Çocukluk Otizm Derecelendirme Ölçeği (ÇODÖ) ile değerlendirilmiştir. Bulgular: Otizm tanılı çocukların başvuru sırasında ortalama ÇODÖ puanları 48.91 (SD: 5.82) idi. Sağlıklı gruba göre otizmli grupta serum TDP-43 ve Serum UCH-L1 düzeyleri anlamlı olarak düşüktü (sırasıyla 506,21±780,97 ng/L ve 1245,80±996,76 ng/L; 3,08±5,44 ng/mL ve 8,64±6,67 ng/mL; p<0.001). Serum TDP-43 and UCH-L1 düzeyleri arasında pozitif korelasyon anlamlı olarak tespit edildi (r=0.947, n= 24, p<0.001).Sonuç: Sonuç olarak, düşük UCHL-L1 ve TDP-43 düzeylerinin, otizmde bozulmuş ubikitinlenme sürecini yansıtabileceği düşünülmüştür.Batman University Scientific Research Project Coordination Center [BTUBAP-2015-YL1]This research was supported by Grants from Batman University Scientific Research Project Coordination Center (BTUBAP-2015-YL1

Co-existing bipolar disease and 17q12 deletion: a rare case report

Background 17q12 microdeletion syndrome is a rare autosomal dominant chromosomal anomaly, caused by the deletion of a 1.4 Mb-spanning DNA sequence on the long arm of chromosome 17. Herein, we report the first bipolar disease (BPD) case with a 1.6-Mb deletion in the 17q11.2-17q12 chromosome region. Materials and methods Physical examination of the case was performed. Karyotype and microarray analyses were performed for the case and the parents. Results Physical examination revealed mild dysmorphic features such as high and forehead, full cheeks, slightly depressed nasal bridge and arched eyebrow. Chromosomal analysis of the patient revealed 46, XX, del(17)(q12) karyotype, and parents' karyotype were normal. In the microarray analysis of patient, 1.6 megabases deletion was detected in the 17q12 region [arr(hg19) 17q12 (34,611,352-36,248,918) x1]. The microarray analysis of the mother was normal. The father's microarray showed 473 kilobases duplication in the 11p11.12 region. Conclusion Although 17q12 deletion syndrome has been associated with bipolar disorder, very few such cases have been described in the literature. Genetic counseling should be considered in patients with remarkable phenotype, complex symptomatology, neurodevelopmental disorder and additional conspicuous medical conditions