A simple animation package

This paper discusses a simple animation package that animates sketches drawn by the user through a simple set of operations. The purpose of the animation package is to demonstrate various computer graphics principles to those who are not experienced in the subject. Furthermore, it is an education tool for both art and undergraduate students. An expanded set of utilities allows for journaling for playback as well as a single level undo. This provides for an easy modification or correction of the errors that can be made during any session. The system is written in C language on a Unix workstation environment. User input is handled through a menu driven system and the benefits of an event driven window environment are fully made use of [6]. This obviously simplifies the usage of the package by the merits of such an environment

Experimental analysis of R134a condensation in vertical narrow channels

Herhangi bir ısıl sistemde faz değişimi olması halinde, olmaması haline göre daha fazla ısı geçişinin gerçekleşmesi, araştırmacıları bu alanda çalışma yapmaya sevk etmiştir. Bu husus göz önünde tutularak bu çalışmada; bir faz değişimi olan yoğuşma, deneysel olarak incelenmiştir. Deneysel çalışma kapsamında kurulan deney tesisatında; R134a soğutucu akışkanının, aralarında silindirik tüpün de bulunduğu 5 farklı düşey mini kanaldaki laminer yoğuşması incelenmiştir. Deneylerde kullanılan test üniteleri; silindirik tüp ile 4 adet çok-girişli kanallardır. Pratikte bundy boru olarak adlandırılan silindirik kanalın iç çapı 3.3 mm olup, üzeri bakır kaplı çelikten imal edilmiştir. Çok-girişli kanallar ise; farklı hidrolik çaplarda olmak üzere, 3-girişli, 5-girişli, 6-girişli ve 14-girişli olup alüminyumdan imal edilmiş kanallardır. Söz konusu bu çok-girişli kanalların hidrolik çapları sırasıyla, 4.74 mm, 3.6 mm, 1.53 mm ve 1.02 mm’dir. Böylece; kanal geometrisinin ve hidrolik çapının, R134a yoğuşmasında ısı geçişi ve basınç düşümü üzerindeki etkisi deneysel olarak tespit edilmiştir. Deneyler; farklı doyma sıcaklıkları ve farklı kütlesel akılar için tekrarlanmıştır. Böylece; düşey kanallardaki R134a soğutucu akışkanının yoğuşması, farklı doyma sıcaklıkları ve farklı kütlesel akılar için karşılaştırılabilmiştir. Ayrıca; bütün kanallardaki deneysel sonuçlardan hareketle, soğutucu akışkanların yoğuşması ile ilgili olarak literatürde yaygın bir şekilde yer alan korelasyonlara benzer bir korelasyon geliştirilmiştir. Yoğuşmada Nu sayısı için geliştirilen bu boyutsuz korelasyonun, literatürdeki korelasyonlar ile oldukça uyumlu olduğu görülmüştür. Anahtar Kelimeler: R134a yoğuşması, ısı taşınım katsayısı, sürtünme faktörü, düşey silindirik tüp, çok-girişli kanallar. In any thermal system, the fact that more heat is transferred in the occurrence of phase change is a motivation for the researchers to work on. Furthermore, it has become inevitable to build smaller (more compact) heating and cooling systems, while the technology is improving more and more. This resulted in the necessity of the occurrence of phase changes in smaller spaces. Therefore it is required to know the mechanisms of phase change in narrow spaces and to improve heat transfer. Taking these facts into consideration, this study is performed to investigate condensation, which is a frequently encountered phase change in thermal systems, in experimental aspect. In the experimental study, laminar condensation of coolant R134a is investigated for five different vertical mini channels including the vertical cylindrical tube and the other four multi-port channels. The cylindrical channel with an inner diameter of 3.3 mm is made of steel coated with copper. The other four multi-port mini channels, which have 3 ports, 5 ports, 6 ports and 14 ports, are made of aluminum. The hydraulic diameters of these multi-port channels are 4.74 mm, 3.6 mm, 1.53 mm and 1.02 mm, respectively. In this way, the effects of channel configuration and hydraulic diameter on heat transfer and pressure drop for R134a condensation are determined experimentally. In the experimental investigation, the average values of thermal parameters and pressure drop are obtained along the test unit. The experiments are repeated for different saturation temperatures (therefore different saturation pressures) and for different mass fluxes. Condensation data are taken for refrigerant R134a at 32 °C and 42 °C saturation temperatures for all mini channels. Therefore, it has been possible to compare the condensation of coolant R134a in cylindrical and multi-port channels for different saturation temperatures and different mass fluxes. The experimental setup established for this study consists of the following twelve main items: coolant pump, flowmeter to measure the flow rate of the coolant R134a, pre-heating section, heating section (superheater), condensation unit, a transparent Plexiglass heat exchanger covering the condensation unit, a rotameter to measure the flow rate of the cooling water, pre-cooling section, cooling section, a receiver, a thermostatic reservoir for cooling water supply and a data acquisition system. As shown in Figure 1, refrigerant R134a enters the test section at a known vapor quality. It is condensed in the test section against the cooling water flowing in the annulus. The two-phase mixture leaving the test section enters a post- condenser. The subcooled liquid is then passed through a receiver which is in a cooler and the coolant pump. The pump moves the liquid to the pre-heater and the electric post-heater (superheater) which fixes the test section inlet vapor quality. The flowmeter is placed between the pump and the pre-heater to measure refrigerant flow rate in liquid phase. The refrigerant flow rate can be independently controlled by the pump. The inlet vapor quality is determined by the heat input to the electric post heater which can be independently controlled. The test section saturation temperature is controlled by adjusting the cooling water flow rate. The experimental results are investigated in two parts, thermal and hydrodynamic analysis. In the thermal analysis, graphs are obtained for the variation of average heat transfer coefficient with respect to average steam quality. As a result, it is shown that the average heat transfer coefficient increases when the average steam quality is increased. Also, graphs are obtained for the variation of average Nu number with respect to equivalent Re number. Similarly as a result, it is shown that the average Nu number increases when the equivalent Re number is increased. In the hydrodynamic analysis part, graphs are obtained for the variation of the pressure loss due to friction during condensation with respect to average steam quality. Also, other graphs are obtained for the two-phase friction coefficient during condensation with respect to equivalent Re number. As a result, mathematical relations are developed between ftp and Reeq for all mini channels. It is found that the two-phase friction coefficient decreases when the Reeq number is increased similar to Moody chart. As a result, a simple dimensionless correlation is developed for Nu number in refrigerant condensation which is in good agreement with the correlations in literature. Keywords: R134a condensation, heat convective coefficient, friction factor, vertical cylindrical tube, multi-port channels. 

Termoakustik soğutucu analizi

Acoustic waves consist of pressure, displacement and temperature oscillations as a response to the pressure variations. The interaction of these effects in gas close to a solid surface generates thermoacoustic oscillations. At the solid surface heat can be extracted or supplied to the gas. The result of this interaction is that acoustic work is absorbed in order to transport heat, generating a temperature gradient along the solid surface. While in the reverse case a sound wave is sustained in case of a large temperature gradient along the solid surface. Utilizing this effect, heat can be transferred from a low temperature source to a high temperature source by a thermoacoustic refrigerator, while the opposite process can be achieved by a thermoacoustic prime mover which converts heat applied on solid surface to acoustical work. Thermoacoustic effects have attracted the scientist's attention for over two centuries. But a quantitatively accurate understanding was not achieved until Rott's (1969) studies, which has been confirmed experimentally by Yazaki et al (1979). Many thermoacoustic engines have been constructed and analyzed till now with an increasing interest. One reason for the increasing interest in thermoacoustics is from its potentiality of environment protection. Conventional refrigerators with freon gas as their working fluid are being prohibited because of its destruction of ozone layer. But the thermoacoustic engines do not use any harmful working fluid. They use mainly helium, or helium with argon, neon, xenon or such inert gaseous. The other reason is that conventional systems have moving parts, so they are less reliable and more expensive than thermoacoustic devices. Because thermoacoustic devices use no moving parts, no close tolerances, no exotic materials, the interests on thermoacoustic engines have increased a lot. In this study a thermoacoustic cooler working with atmospheric air was designed and constructed. A systematical approach was followed to design the device which had been proposed by Tijani. The system was constructed with a speaker as the acoustical source, resonator, stacks at different lengths, stack holder, signal generator, amplifier, temperature and pressure measurement system. After constructing the thermoacoustic device, pressure distributions in the resonator at various resonance frequencies were examined. The resonance frequencies of the system were approximately measured at 112 Hz, 180 Hz and 300 Hz starting from the first harmonics. The theoretical and experimental pressure distributions were compared. Changes of pressure antinode position with respect to acoustical source amplitude at resonance frequencies were studied theoretically and experimentally. The analytical and experimental results were  compared. Three stacks at different lengths were constructed. After that the temperature distributions on the stack at different stack positions were examined and compared to the theoretical results with and without taking care of axial conduction effects. The maximum temperature difference, measured between the tips of the stacks are 20.4oC (10 cm length stack), 21.4oC (15 cm length stack), 27.6oC (22 cm length stack). It was concluded that the axial conduction effects are important in a system at low power. It was also measured the steady state temperature distribution on stack, and it was seen that it was linear as it should be. Later it was examined how the existence and the position of the stack affects the pressure distribution and the resonance frequency of the system. It was concluded that the existence and the position of the stack in the resonator affects the resonance frequency and pressure antinode position. In the experiments, it was measured that the resonance frequency of the system was changed between 108 Hz and 112 Hz depending on the stack position while the resonance frequency of the empty resonator is 112 Hz. Despite the fact that pressure antinode position from open end of the resonator was measured 72 cm at empty resonator resonance frequency, it was observed that the pressure antinode position decreased down to 66 cm as a result of the stack inside the resonator. At the end it was examined how slight frequency changes affects the system performance. It was measured that a few Hertz frequency changes does not affect the system performance a lot, but there is a sharp decrease at the system performance if the frequency changes are larger than a few Hertz. Keywords: Thermoacoustics, thermoacoustic cooler, thermoacoustic engine.Ses dalgaları içerisindeki basınç salınımları ile birlikte gerçekleşen sıcaklık salınımları sonucu  akışkan ve akışkana temas eden katı yüzey arasındaki ısıl etkileşimler termoakustik olarak adlandırılır. Termoakustik sistemlerin maliyetlerinin düşük, yapılarının basit olması, atmosfere zarar veren gazlar kullanmaması, hareketli parçalarının bulunmaması gibi sebeplerle, klasik soğutma sistemlerine göre pratikteki verimlerinin düşük olmalarına rağmen üzerlerindeki ilgi artarak devam etmiştir. Termoakustik soğutucular geleceğin soğutma teknolojilerinden birisi olmaya adaydır. Bu çalışmada atmosferik hava ile çalışan basit bir termoakustik soğutucu dizayn ve inşa edilmiş, daha sonra sistem üzerinde çeşitli inceleme ve analizler yapılmıştır. Sistemin rezonans frekansları birinci harmonikten itibaren yaklaşık olarak 112 Hz, 180 Hz, 300 Hz olarak ölçülmüştür. Akustik kaynak olarak bir hoparlör kullanıldığından ideal rezonans tüpünden farklı olarak kapalı uçta hız nodunun oluşmadığı görülmüştür. Daha sonra sistemdeki basınç dağılımının şeklinin akustik kaynak genliğine bağlı olarak değişimi incelenmiştir. Ardından üç farklı uzunlukta yığın kullanılarak farklı yığın pozisyonlarında yığın üzerindeki sıcaklık dağılımları ve yığın uçları arasındaki sıcaklık farkları ölçülmüş ve teoriyle karşılaştırılmıştır. Yığınların her iki ucu arasında en yüksek 27.6oC sıcaklık farkı ölçülmüştür. Daha sonra rezonans tüpü içerisinde yığının varlığının ve pozisyonunun sistemin basınç dağılımı ve rezonans frekansı üzerine etkileri incelenmiştir. Yığının sistem içindeki varlığının ve pozisyonunun sistem çalışma frekansını ve basınç antinod pozisyonunu etkilediği gözlenmiştir. Son olarak sistemin çalışma frekansındaki kaymaların sistem performansı üzerine etkileri incelenmiştir. Anahtar Kelimeler: Termoakustik, termoakustik soğutucu, termoakustik makine.&nbsp

Motion control for realistic walking behavior using inverse kinematics

This study presents an interactive hierarchical motion control system for the animation of human figure locomotion. The articulated figure animation system creates movements using motion control techniques at different levels, like goal-directed motion and walking. Inverse Kinematics using Analytical Methods (IKAN) software, developed at the University of Pennsylvania, is utilized for controlling the motion of the articulated body. © 2007 IEEE

Automated LASCO CME catalog for solar cycle 23: are CMEs scale invariant?

In this paper we present the first automatically constructed LASCO CME catalog, a result of the application of the Computer Aided CME Tracking software (CACTus) on the LASCO archive during the interval September 1997 - January 2007. We have studied the CME characteristics and have compared them with similar results obtained by manual detection (CDAW CME catalog). On average CACTus detects less than 2 events per day during solar minimum up to 8 events during maximum, nearly half of them being narrow (< 20 degrees). Assuming a correction factor, we find that the CACTus CME rate is surprisingly consistent with CME rates found during the past 30 years. The CACTus statistics show that small scale outflow is ubiquitously observed in the outer corona. The majority of CACTus-only events are narrow transients related to previous CME activity or to intensity variations in the slow solar wind, reflecting its turbulent nature. A significant fraction (about 15%) of CACTus-{\it only} events were identified as independent events, thus not related to other CME activity. The CACTus CME width distribution is essentially scale invariant in angular span over a range of scales from 20 to 120 degrees while previous catalogues present a broad maximum around 30 degrees. The possibility that the size of coronal mass outflows follow a power law distribution could indicate that no typical CME size exists, i.e. that the narrow transients are not different from the larger well-defined CMEs.Comment: 13 pages. ApJ, accepte

Investigation of heat transfer in moving liquid column

Bu &ccedil;alışmada, halkasal zorlanmış salınımlı akışta ısı ge&ccedil;işi deneysel ve sayısal olarak incelenmektedir.&nbsp; Halkasal kesit i&ccedil;inde akışkan bir piston-silindir d&uuml;zeneği ile farklı frekans, genlik ve ısı y&uuml;k&uuml;nde titreştirilmektedir. Deneyler farklı ısı akıları ve frekanslar i&ccedil;in yapılmış olup bu frekanslara karşılık gelen Nusselt sayıları bulunarak, boyutsuz sayılar cinsinden bir korelasyon eşitliği ile verilmektedir. Ayrıca sonlu hacimler ayrıklaştırma y&ouml;ntemine g&ouml;re &ccedil;&ouml;z&uuml;m yapan FLUENT yazılımı kullanılarak Hareketli Sıvı Kolonunda ısı ge&ccedil;işi sayısal olarak da incelenmektedir. Yapılan incelemelerde, sıvı i&ccedil;erisindeki hız ve sıcaklık dağılımı elde edilerek ısı ge&ccedil;iş mekanizması a&ccedil;ıklanmaktadır. Isı ge&ccedil;işinde etkili olan mekanizmanın akışın merkezini takip edemeyen hidrodinamik sınır tabakadan kaynaklandığı ve bunun ısı ge&ccedil;işini artırdığı anlaşılmıştır. Sayısal &ccedil;&ouml;z&uuml;m i&ccedil;inde bir &ccedil;evrimde suya ge&ccedil;en ısı i&ccedil;in Nusselt sayıları bulunarak deneysel sonu&ccedil;larla karşılaştırılmaktadır. &nbsp;Anahtar Kelimeler: Hareketli sıvı kolonu, salınımlı akış, Nusselt sayısı.In this study, the heat transfer from a surface heated with constant heat flux to an oscillating vertical annular liquid column having an interface with the atmosphere is investigated experimentally and numerically.  The reciprocating motion of water column is created using a piston cylinder mechanism. The space-cycle heat transfer rate from heater to water was calculated by using experimental measurements. The analysis was carried out for the case of different oscillation frequencies while the displacement amplitude remains constant.  Based on the experimental data a correlation equation was obtained for the cycle-averaged Nusselt number as a function of kinetic Reynolds number.  Heat transfer in the moving liquid column was also investigated numerically using the FLUENT program.  Fluent uses a control-volume-based technique to convert the governing equations to algebraic equations that can be solved numerically. This control volume technique consists of integrating the governing equations about each control volume, yielding discrete equations that conserve each quantity on a control-volume basis. It is clear that heat transfer rate depends on velocity and temperature profile.  The numerical results reveal that there is a phase difference between hydrodynamic boundary layer and core flow, which improves the heat transfer.  The averaged heat transfer rate is found to increase with the frequency. The space-cycle averaged Nusselt number was found numerically and compared with experimental results. The numerical solution is in good agreement with the experimental data. Keywords: Oscillating liquid column, reciprocating flow, Nusselt number

Right-triangular subdivision for texture mapping ray-traced objects

The introduction of global illumination and texture mapping enabled the generation of high-quality, realistic looking images of computer graphics models. We describe a fast and efficient 2D texture mapping algorithm that uses triangle-to-triangle mapping, taking advantage of mapping an arbitrary triangle to a right triangle. This requires fewer floating point operations for finding the 2D texture coordinates and little preprocessing and storage. Texture mapping is combined with ray tracing for better visual effects. A filtering technique alternative to area sampling is developed to avoid aliasing artifacts. This technique uses linear eye rays, and only one eye ray per pixel is fired. A uniform supersampling filtering technique eliminates aliasing artifacts at the object edges

Tests of sunspot number sequences: 1. Using ionosonde data

More than 70 years ago it was recognised that ionospheric F2-layer critical frequencies [foF2] had a strong relationship to sunspot number. Using historic datasets from the Slough and Washington ionosondes, we evaluate the best statistical fits of foF2 to sunspot numbers (at each Universal Time [UT] separately) in order to search for drifts and abrupt changes in the fit residuals over Solar Cycles 17-21. This test is carried out for the original composite of the Wolf/Zürich/International sunspot number [R], the new “backbone” group sunspot number [RBB] and the proposed “corrected sunspot number” [RC]. Polynomial fits are made both with and without allowance for the white-light facular area, which has been reported as being associated with cycle-to-cycle changes in the sunspot number - foF2 relationship. Over the interval studied here, R, RBB, and RC largely differ in their allowance for the “Waldmeier discontinuity” around 1945 (the correction factor for which for R, RBB and RC is, respectively, zero, effectively over 20 %, and explicitly 11.6 %). It is shown that for Solar Cycles 18-21, all three sunspot data sequences perform well, but that the fit residuals are lowest and most uniform for RBB. We here use foF2 for those UTs for which R, RBB, and RC all give correlations exceeding 0.99 for intervals both before and after the Waldmeier discontinuity. The error introduced by the Waldmeier discontinuity causes R to underestimate the fitted values based on the foF2 data for 1932-1945 but RBB overestimates them by almost the same factor, implying that the correction for the Waldmeier discontinuity inherent in RBB is too large by a factor of two. Fit residuals are smallest and most uniform for RC and the ionospheric data support the optimum discontinuity multiplicative correction factor derived from the independent Royal Greenwich Observatory (RGO) sunspot group data for the same interval

EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015

Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of IDO in a murine model of gingivitis: predictive and therapeutic potentials Babak Baban, Jun Yao Liu, Xu Qin, Tailing Wang, Mahmood S. Mozaffari A6 Specific diets for personalised treatment of diabetes type 2 Viktoriia V. Bati, Tamara V. Meleshko, Olga B. Levchuk, Nadiya V. Boyko A7 Towards personalized physiotherapeutic approach Joanna Bauer, Ewa Boerner, Halina Podbielska A8 Cells, animal, SHIME and in silico models for detection and verification of specific biomarkers of non-communicable chronic diseases Alojz Bomba, Viktor O. Petrov, Volodymyr G. Drobnych, Rostyslav V. Bubnov, Oksana M. Bykova, Nadiya V. Boyko A9 INTERACT-chronic care model: Self-treatment by patients with decision support e-Health solution Hans-Peter Brunner-La Rocca, Lutz Fleischhacker, Olga Golubnitschaja, Frank Heemskerk, Thomas Helms, Tiny Jaarsma, Judita Kinkorova, Jan Ramaekers, Peter Ruff, Ivana Schnur, Emilio Vanoli, Jose Verdu A10 PPPM in cardiovascular medicine in 2015 Hans-Peter Brunner-La Rocca A11 Magnetic resonance imaging of nanoparticles in mice, potential for theranostic and contrast media development – pilot results Rostyslav V. Bubnov, Sergiy A. Grabovetskyi, Olena M. Mykhalchenko, Natalia O. Tymoshok, Oleksandr B. Shcherbakov, Igor P. Semeniv, Mykola Y. Spivak A12 Ultrasound diagnosis for diabetic neuropathy - comparative study Rostyslav V. Bubnov, Tetyana V. Ostapenko A13 Ultrasound for stratification patients with diabetic foot ulcers for prevention and personalized treatment - pilot results Rostyslav V. Bubnov, Nazarii M. Kobyliak, Nadiya M. Zholobak, Mykola Ya. Spivak A14 Project ImaGenX – designing and executing a questionnaire on environment and lifestyle risk of breast cancer John Paul Cauchi A15 Genomics – a new structural brand of predictive, preventive and personalized medicine or the new driver as well? Dmitrii Cherepakhin, Marina Bakay, Artem Borovikov, Sergey Suchkov A16 Survey of questionnaires for evaluation of the quality of life in various medical fields Barbara Cieślik, Agnieszka Migasiewicz, Maria-Luiza Podbielska, Markus Pelleter, Agnieszka Giemza, Halina Podbielska A17 Personalized molecular treatment for muscular dystrophies Sebahattin Cirak A18 Secondary mutations in circulating tumour DNA for acquired drug resistance in patients with advanced ALK + NSCLC Marzia Del Re, Paola Bordi, Valentina Citi, Marta Palombi, Carmine Pinto, Marcello Tiseo, Romano Danesi A19 Recombinant species-specific FcεRI alpha proteins for diagnosis of IgE-mediated allergies in dogs, cats and horses Lukas Einhorn, Judit Fazekas, Martina Muhr, Alexandra Schoos, Lucia Panakova, Ina Herrmann, Krisztina Manzano-Szalai, Kumiko Oida, Edda Fiebiger, Josef Singer, Erika Jensen-Jarolim A20 Global methodology for developmental neurotoxicity testing in humans and animals early and chronically exposed to chemical contaminants Arpiné A. Elnar, Nadia Ouamara, Nadiya Boyko, Xavier Coumoul, Jean-Philippe Antignac, Bruno Le Bizec, Gauthier Eppe, Jenny Renaut, Torsten Bonn, Cédric Guignard, Margherita Ferrante, Maria Liusa Chiusano, Salvatore Cuzzocrea, Gerard O'Keeffe, John Cryan, Michelle Bisson, Amina Barakat, Ihsane Hmamouchi, Nasser Zawia, Anumantha Kanthasamy, Glen E. Kisby, Rui Alves, Oscar Villacañas Pérez, Kim Burgard, Peter Spencer, Norbert Bomba, Martin Haranta, Nina Zaitseva, Irina May, Stéphanie Grojean, Mathilde Body-Malapel, Florencia Harari, Raul Harari, Kristina Yeghiazaryan, Olga Golubnitschaja, Vittorio Calabrese, Christophe Nemos, Rachid Soulimani A21 Mental indicators at young people with attributes hypertension and pre-hypertension Maria E. Evsevyeva, Elena A. Mishenko, Zurida V. Kumukova, Evgeniy V. Chudnovsky, Tatyana A. Smirnova A22 On the approaches to the early diagnosis of stress-induced hypertension in young employees of State law enforcement agencies Maria E. Evsevyeva, Ludmila V. Ivanova, Michail V. Eremin, Maria V. Rostovtseva A23 Сentral aortic pressure and indexes of augmentation in young persons in view of risk factors Maria E. Evsevyeva, Michail V. Eremin, Vladimir I. Koshel, Oksana V. Sergeeva, Nadesgda M. Konovalova A24 Breast cancer prediction and prevention: Are reliable biomarkers in horizon? Shantanu Girotra, Olga Golubnitschaja A25 Flammer Syndrome and potential formation of pre-metastatic niches: A multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease Olga Golubnitschaja, Manuel Debald, Walther Kuhn, Kristina Yeghiazaryan, Rostyslav V. Bubnov, Vadym M. Goncharenko, Ulyana Lushchyk, Godfrey Grech, Katarzyna Konieczka A26 Innovative tools for prenatal diagnostics and monitoring: improving individual pregnancy outcomes and health-economy in EU Olga Golubnitschaja, Jan Jaap Erwich, Vincenzo Costigliola, Kristina Yeghiazaryan, Ulrich Gembruch A27 Immunohistochemical assessment of APUD cells in endometriosis Vadym M. Goncharenko, Vasyl O. Beniuk, Olga V. Kalenska, Rostyslav V. Bubnov A28 Updating personalized management algorithm of endometrial hyperplasia in pre-menopause women Vadym M. Goncharenko, Vasyl O. Beniuk, Rostyslav V. Bubnov, Olga Melnychuk A29 The personified treatment approach of polimorbid patients with periodontal inflammatory diseases Irina A. Gorbacheva, Lyudmila Y. Orekhova, Vadim V. Tachalov A30 Ukrainian experience in hybrid war – the challenge to update algorithms for personalized care and early prevention of different military injuries Olena I. Grechanyk, Rizvan Ya. Abdullaiev, Rostyslav V. Bubnov A31 Tear fluid biomarkers: a comparison of tear fluid sampling and storage protocols Suzanne Hagan, Eilidh Martin, Ian Pearce, Katherine Oliver A32 The correlation of dietary habits with gingival problems during menstruation Cenk Haytac, Fariz Salimov, Servin Yoksul, Anatoly A. Kunin, Natalia S. Moiseeva A33 Genomic medicine in a contemporary Spanish population of prostate cancer: our experience Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara, Antonia Angulo, Francisco Javier Machuca Santa-Cruz A34 Challenges, opportunities and collaborations for personalized medicine applicability in uro-oncological disease Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara A35 Metabolic hallmarks of cancer as targets for a personalized therapy John Ionescu A36 Influence of genetic polymorphism as a predictor of the development of periodontal disease in patients with gastric ulcer and 12 duodenal ulcer Alfiya Z. Isamulaeva, Anatoly A. Kunin, Shamil Sh. Magomedov, Aida I. Isamulaeva A37 Challenges in diabetic macular edema Tatjana Josifova A38 Overview of the EPMA strategies in laboratory medicine relevant for PPPM Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja, Vincenzo Costigliola A39 EPMA initiative for effective organization of medical travel: European concepts and criteria Vincenzo Costigliola, Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja A40 Design and innovation in e-textiles: implications for PPPM Anthony Kent, Tom Fisher, Tilak Dias A41 Biobank in Pilsen as a member of national node BBMRI_CZ Judita Kinkorová, Ondřej Topolčan A42 Big data in personalized medicine: hype and hope Matthias Kohl A43 The 3P approach as the platform of the European Dentistry Department (DPPPD) Anatoly A. Kunin, Natalia S. Moiseeva A44 The endometrium cytokine patterns for predictive diagnosis of proliferation severity and cancer prevention Andrii I. Kurchenko, Vasyl A. Beniuk, Vadym M. Goncharenko, Rostyslav V. Bubnov, Nadiya V. Boyko, Andriy M. Strokan A45 A monocyte-based in-vitro system for testing individual responses to the implanted material: future for personalized implant construction Julia Kzhyshkowska, Alexandru Gudima, Ksenia S. Stankevich, Victor D. Filimonov4, Harald Klüter, Evgeniya M. Mamontova, Sergei I. Tverdokhlebov A46 Prediction and prevention of adverse health effects by meteorological factors: Biomarker patterns and creation of a device for self-monitoring and integrated care Ulyana B. Lushchyk, Viktor V. Novytskyy, Igor P. Babii, Nadiya G. Lushchyk, Lyudmyla S. Riabets, Ivanna I. Legka A47 Targeting "disease signatures" towards personalized healthcare Mira Marcus-Kalish, Alexis Mitelpunkt, Tal Galili, Neta Shachar, Yoav Benjamini A48 Influence of the skin imperfection on the personal quality of life and possible tools for objective diagnosis Agnieszka Migasiewicz, Markus Pelleter, Joanna Bauer, Ewelina Dereń, Halina Podbielska A49 The new direction in caries prevention based on the ultrastructure of dental hard tissues and filling materials Natalia S. Moiseeva, Anatoly A. Kunin, Dmitry A. Kunin A50 The use of LED radiation in prevention of dental diseases Natalia S. Moiseeva, Yury A. Ippolitov, Dmitry A. Kunin, Alexei N. Morozov, Natalia V. Chirkova, Nakhid T. Aliev A51 Status of endothelial progenitor cells in diabetic nephropathy: predictive and preventive potentials Mahmood S. Mozaffari, Jun Yao Liu, Babak Baban A52 The status of glucocorticoid-induced leucine zipper protein in salivary gland in Sjögren’s syndrome: predictive and personalized treatment potentials Mahmood S. Mozaffari, Jun Yao Liu, Rafik Abdelsayed, Xing-Ming Shi, Babak Baban A53 Maximal aerobic capacity - important quality marker of health Jaroslav Novák, Milan Štork, Václav Zeman A54 The EMPOWER project: laboratory medicine and Horizon 2020 Wytze P. Oosterhuis, Elvar Theodorsson A55 Personality profile manifestations in patient’s attitude to oral care and adherence to doctor’s prescriptions Lyudmila Y. Orekhova, Tatyana V. Kudryavtseva, Elena R. Isaeva, Vadim V. Tachalov, Ekaterina S. Loboda A56 Results of an European survey on personalized medicine addressed to directions of laboratory medicine Mario Pazzagli, Francesca Malentacchi, Irene Mancini, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc, Ron H.N. van Schaik, Gerard Siest, Elvar Theodorsson, Chiara Di Resta A57 MCI or early dementia predictive speech based diagnosis techniques Matus Pleva, Jozef Juhar A58 Personalized speech based mobile application for eHealth Matus Pleva, Jozef Juhar A59 Circulating tumor cell-free DNA as the biomarker in the management of cancer patients Jiří Polívka jr., Filip Janků, Martin Pešta, Jan Doležal, Milena Králíčková, Jiří Polívka A60 Complex stroke care – educational programme in Stroke Centre University Hospital Plzen Jiří Polívka, Alena Lukešová, Nina Müllerová, Petr Ševčík, Vladimír Rohan A61 Sleep apnea and sleep fragmentation contribute to brain aging Kneginja Richter, Lence Miloseva, Günter Niklewski A62 Personalised approach for sleep disturbances in shift workers Kneginja Richter, Jens Acker, Guenter Niklewski A63 Medical travel and innovative PPPM clusters: new concept of integration Olga Safonicheva, Vincenzo Costigliola A64 Medical travel and women health Olga Safonicheva A65 Continuity of generations in the training of specialists in the field of reconstructive microsurgery Maxim Sautin, Janna Sinelnikova, Sergey Suchkov A66 Telemonitoring of stroke patients – empirical evidence of individual risk management results from an observational study in Germany Songül Secer, Stephan von Bandemer A67 Women’s increasing breast cancer risk with n-6 fatty acid intake explained by estrogen-fatty acid interactive effect on DNA damage: implications for gender-specific nutrition within personalized medicine Niva Shapira A68 Cytobacterioscopy of the gingival crevicular fluid as a method for preventive diagnosis of periodontal diseases Aleksandr Shcherbakov, Anatoly A. Kunin, Natalia S. Moiseeva A69 Use of specially treated composites in dentistry to avoid violations of aesthetics Bogdan R. Shumilovich, Zhanna Lipkind, Yulia Vorobieva, Dmitry A. Kunin, Anastasiia V. Sudareva A70 National eHealth system – platform for preventive, predictive and personalized diabetes care Ivica Smokovski, Tatjana Milenkovic A72 The common energy levels of Prof. Szent-Györgyi, the intrinsic chemistry of melanin, and the muscle physiopathology. Implications in the context of Preventive, Predictive, and Personalized Medicine Arturo Solís-Herrera, María del Carmen Arias-Esparza, Sergey Suchkov A73 Plurality and individuality of hepatocellular carcinoma: PPPM perspectives Krishna Chander Sridhar, Olga Golubnitschaja A74 Strategic aspects of higher medical education reforms to secure newer educational platforms for getting biopharma professionals matures Maria Studneva, Sihong Song, James Creeden, Мark Мandrik, Sergey Suchkov A75 Overview of the strategies and activities of the European Federation of Clinical Chemistry and Laboratory Medicine, (EFLM) Elvar Theodorsson, EFLM A76 New spectroscopic techniques for point of care label free diagnostics Syed A. M. Tofail A77 Tumor markers for personalized medicine and oncology - the role of Laboratory Medicine Ondřej Topolčan, Judita Kinkorová, Ondřej Fiala, Marie Karlíková, Šárka Svobodová, Radek Kučera, Radka Fuchsová, Vladislav Třeška, Václav Šimánek, Ladislav Pecen, Jan Šoupal, Štěpán Svačina2 A78 Modern medical terminology (MMT) as a driver of the global educational reforms Evgeniya Tretyak, Maria Studneva, Sergey Suchkov A79 Juvenile hypertension; the relevance of novel predictive, preventive and personalized assessment of its determinants Francesca M. Trovato, G. Fabio Martines, Daniela Brischetto, Daniela Catalano, Giuseppe Musumeci, Guglielmo M. Trovato A80 Proteomarkers Biotech George Th. Tsangaris, Athanasios K. Anagnostopoulos A81 Proteomics and mass spectrometry based non-invasive prenatal testing of fetal health and pregnancy complications George Th. Tsangaris, Athanasios K. Anagnostopoulos A82 Integrated Ecosystem for an Integrated Care model for Heart Failure (HF) patients including related comorbidities (ZENITH) José Verdú, German Gutiérrez, Jordi Rovira, Marta Martinez, Lutz Fleischhacker, Donna Green, Arthur Garson, Elena Tamburini, Stefano Cuomo, Juan Martinez-Leon, Teresa Abrisqueta, Hans-Peter Brunner-La Rocca, Tiny Jaarsma, Teresa Arredondo, Cecilia Vera, Giuseppe Fico, Olga Golubnitschaja, Fernando Arribas, Martina Onderco, Isabel Vara, on behalf of ZENITH consortium A83 Predictive, preventive and personalized medicine in diabetes onset and complication (MOSAIC project) José Verdú, Francesco Sambo, Barbara Di Camillo, Claudio Cobelli, Andrea Facchinetti, Giuseppe Fico, Riccardo Bellazzi, Lucia Sacchi, Arianna Dagliati, Daniele Segnani, Valentina Tibollo, Manuel Ottaviano, Rafael Gabriel, Leif Groop, Jacqueline Postma, Antonio Martinez, Liisa Hakaste, Tiinamaija Tuomi, Konstantia Zarkogianni, on behalf of MOSAIC consortium A84 Possibilities for personalized therapy of diabetes using in vitro screening of insulin and oral hypoglycemic agents Igor Volchek, Nina Pototskaya, Andrey Petrov A85 The innovative technology for personalized therapy of human diseases based on in vitro drug screening Igor Volchek, Nadezhda Pototskaya, Andrey Petrov A86 Bone destruction and temporomandibular joint: predictive markers, pathogenetic aspects and quality of life Ülle Voog-Oras, Oksana Jagur, Edvitar Leibur, Priit Niibo, Triin Jagomägi, Minh Son Nguyen, Chris Pruunsild, Dagmar Piikov, Mare Saag A87 Sub-optimal health management – global vision for concepts in medical travel Wei Wang A88 Sub-optimal health management: synergic PPPM-TCAM approach Wei Wang A89 Innovative technologies for minimal invasive diagnostics Andreas Weinhäusel, Walter Pulverer, Matthias Wielscher, Manuela Hofner, Christa Noehammer, Regina Soldo, Peter Hettegger, Istvan Gyurjan, Ronald Kulovics, Silvia Schönthaler, Gabriel Beikircher, Albert Kriegner, Stephan Pabinger, Klemens Vierlinger A90 Rare disease diobanks for personalized medicine Ayşe Yüzbaşıoğlu, Meral Özgüç, Member of EuroBioBank - European Network of DNA, Cell and Tissue Banks for Rare Disease