Analysis of lymphocyte subgroups in Crimean-Congo hemorrhagic fever

SummaryObjectivesThis study examined the association between lymphocyte subgroups and mortality in patients with Crimean-Congo hemorrhagic fever (CCHF) in Turkey.MethodsDuring the spring and summer of 2007, peripheral blood was collected from hospitalized patients with suspected CCHF. Lymphocyte subgroups were characterized by fluorescence-activated cell sorting. CCHF cases were confirmed by detecting viral RNA by PCR and/or IgM antibodies by ELISA. Lymphocyte subgroups were compared between fatal and non-fatal cases. The correlation between lymphocyte subgroups and viral loads was also investigated.ResultsSeventy-seven confirmed cases of CCHF were included in this study (five cases were fatal (6.5 %)). No differences in lymphocyte subgroups were found between fatal and non-fatal cases, except for significantly higher CD3+CD8+ T cells in the fatal cases (p=0.017). A positive correlation between viral load and CD3+CD8+ T cells was also detected (p=0.044). There was no correlation between other lymphocyte subgroups and viral load.ConclusionsHigher levels of CD3+CD8+ T lymphocytes were detected in fatal compared to non-fatal CCHF cases. Despite this cytotoxic immune activation, a fatal outcome could not be prevented. We hypothesize that high viral load and other factors may influence this outcome, although more studies are required to explain the pathogenesis of CCHF

“The Lolelaplap (Marshall Islands) in Us: Sailing West to East (Ralik→Ratak) to These Our Atolls (Aelon Kein Ad) Ad Jolet Jen Anij (Our Blessed Inheritance from God)”

This paper discusses the expansion of Oceania through a Marshallese indigenous lens as a focal point. It explains that decolonizing methodologies allows reclaiming of space for mental liberation and reassurement of constitutional rights. It highlights similar occurrences of decolonization practices meeting resistance in the 21st century all while strengthening the human right argument that no human deserves any less than their fellow human brothers and sisters. It argues that an indigenous imagery can only be viewed through an indigenous lens where the researches’ level of purity is retained and unfiltered. It nevertheless argues that Marshallese ethnolinguistics reveal the same cultural practices in America, Judeo-Christianity, and Oceania thus dictating the reality that “we are the same not withstanding one stays here and one there (Bedbedjin Bedbedjen, Bedbedjinma wot Kwe)”. It further explains the importance in these similarities and how Marshallese spirituality predates introduced American Judeo-Christianity despite the latter attempting to marginalize the former. It concludes by stating that Marshallese contributions on the global stage are rooted in that culture of love (IaKwe) which is echoed by the custom(s) revealing the significance of Marshallese validation academically, spiritually, economically, & socially to prevent institutionalized discrimination. This paper ends stating that the agency to know one’s self and how one should fit in the world, is a human right in itself and Marshallese are entitled to this sense of self worth through knowing thy self by thy self where real thinking takes place in one’s own mind as we all live our own lives

The assesment of the stem cell mobilization in lymphoma patients: a single center experience

European Hematol Asso

The Role of CD200 and CD43 Expression in Differential Diagnosis between Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma

Objective: Atypical chronic lymphocytic leukemia (CLL) is most frequently confused with mantle cell lymphoma (MCL). Several markers may contribute to the diagnosis of CLL. However, there is no consensus on which markers are needed to be used in flow cytometry for the diagnosis of CLL. The aim of the present study was to investigate the role of CD43 and CD200 markers in the differential diagnosis between CLL and MCL. Materials and Methods: To address this issue, 339 consecutive patients with CLL and MCL were included in the flow cytometry lymphoproliferative disease panel for evaluation of CD43 and CD200 expressions, but not in the Matutes scoring system. Results: CD200 was expressed in 97.3% of atypical CLL cases, whereas it was dimly expressed in only 6.1% of MCL cases. CD43 expression was 95.7% in atypical CLL cases. In the MCL cases, its expression rate was 39.4%. Conclusion: CD43 and CD200 were found to be more valuable markers than CD22, CD79b, and FMC7. CD43 and CD200 could also be considered as definitive markers in atypical CLL patients, for whom the Matutes scoring system remains ineffective

The use of complementary and alternative medicine by the stem cell transplantation patients

Çalışma 2006 yılında 32. Ulusal Türk Hematoloji Kongresi’ nde sözel bildiri olarak sunulmuş olup, ‘Genç Katılımcı Ödülü’ almıştır.Bu çalışma kök hücre nakli yapılan hastaların nakil öncesi ya da nakil sonrası TAT uygulamalarının değerlendirilmesi amacıyla tanımlayıcı olarak yapılmıştır. Veriler Ankara’da bulunan 5 hastanede tedavi gören 153 hastadan toplanmıştır. Veri toplama formu sosyo-demografik özellikler ve geçen ve bir önceki yıllardaki ilik nakillerinde TAT kullanımına ilişkin bilgileri kapsamaktadır. Hastaların TAT rak %48.4’ünün şifalı bitkisel ürünleri, %28.1’inin dini aktiviteleri (dualar) kullandığı belirlenmiştir. Hastaların sıklıkla bitkisel ürün olarak ısırgan otunu (%69.0) ,hayvansal ürün olarak ise kaplumbağa kanını kullandığı saptandı. Hastalar çoğunlukla tedavi edici, gevşetici ve manevi güç olarak TAT kullandığını belirtmiştir. Hastaların %79.0’u doktorları ile TAT kullanımlarına ilişkin tartışmadıklarını/danışmadıklarını belirtmiştir. Bu çalışmanın bulgularının diğer çalışmalardakilerle benzer olduğu saptanmıştır.The aim of this descriptive study was to investigate the types and prevalence of complementary and alternative medicine (CAM) use among patients with malignancy who have undergone bone marrow transplantation (before and after). A demographic questionnaire was completed with 153 patients at five hospitals located in Ankara. Data has been collected from a face-to-face interview performed by a nurse. The most common types of CAM used were herbs (%48.4) and pray (%28.1). The most frequently used herb was stinging nettle (%69.0) and animal product was blood of turtle. Common reasons for using CAM were that it is “curative", it gives "relaxation" and evokes "spiritual wellbeing”. Majority of the patients using CAM (%79.0) did not discuss the use of these therapies with their primary physicians. This study revealed that most findings in this study are similar to the results of other studies