1 research outputs found
Duration of nivolumab for pretreated, advanced nonâsmallâcell lung cancer
Abstract Background A standard of care for pretreated, advanced nonâsmallâcell lung cancers (NSCLCs), nivolumab has demonstrated longâterm benefit when administered for 2 years. We aimed to better discern an optimized administration duration by retrospectively analyzing realâlife longâterm efficacy in a prospective cohort. Methods All nivolumabâtreated adults with advanced NSCLCs (01/09/2015 to 30/09/2016) from nine French centers were eligible. On 31/12/2018, patients who are alive â„ 2 years after starting nivolumab were defined as longâterm survivors (LTSs) and were divided into three nivolumab treatment groups:  2 years. Coâprimary endpoints were LTSsâ progressionâfree survival (PFS) and overall survival (OS). Results The median followâup was 32 months (95% CI, 31.0 to 34.0). The 3âyear OS rate for the 259 cohort patients was 16.6%. Among them, 65 were LTSs: 47 treated  2 years. Their respective characteristics were: median age: 59, 52, and 58 years; smoking history: 92.9, 100, and 100%; adenocarcinomas: 66, 57.1, and 54.5%. LTSsâ median (m)PFS was 28.4 months; mOS was not reached. LTSsâ objective response rate was 61.6%. mOS was 32.7 months for those treated  2âyear group's 3âyear OS was longer. Twentyâeight LTSs experienced no disease progression; 7 had durable complete responses. However, LTSs had more frequent and more severe adverse events. Conclusion In realâlife, prolonged nivolumab use provided longâterm benefit with 16.6% 3âyear OS and 25% LTSs. Survival tended to be prolonged with nivolumab continued beyond 2 years. Prospective randomized trials with adequate design are needed