Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis

This study aimed to develop a suitable buccal mucoadhesive nanoparticle (NP) formulation containing fluconazole for the local treatment of oral candidiasis. The suitability of the prepared formulations was assessed by means of particle size (PS), polydispersity index, and zeta potential measurements, morphology analysis, mucoadhesion studies, drug entrapment efficiency (EE), in vitro drug release, and stability studies. Based on the optimum NP formulation, ex vivo drug diffusion and in vitro cytotoxicity studies were performed. Besides, evaluation of the antifungal effect of the optimum formulation was evaluated using agar diffusion method, fungicidal activity-related in vitro release study, and time-dependent fungicidal activity. The effect of the optimum NP formulation on the healing of oral candidiasis was investigated in an animal model, which was employed for the first time in this study. The zeta potential, mucoadhesion, and in vitro drug release studies of various NP formulations revealed that chitosan-coated NP formulation containing EUDRAGIT(®) RS 2.5% had superior properties than other formulations. Concerning the stability study of the selected formulation, the formulation was found to be stable for 6 months. During the ex vivo drug diffusion study, no drug was found in receptor phase, and this is an indication of local effect. The in vitro antifungal activity studies showed the in vitro efficacy of the NP against Candida albicans for an extended period. Also, the formulation had no cytotoxic effect at the tested concentration. For the in vivo experiments, infected rabbits were successfully treated with local administration of the optimum NP formulation once a day. This study has shown that the mucoadhesive NP formulation containing fluconazole is a promising candidate with once-a-day application for the local treatment of oral candidiasis

Beyond national narratives? : centenary histories, the First World War and the Armenian Genocide

In April 2015 the centenary of the Armenian Genocide was commemorated. Just like the First World War centenary, this anniversary has provoked a flurry of academic and public interest in what remains a highly contested history. This article assesses the state of the current historiography on the fate of the Ottoman Armenians. It focuses on the possibilities for moving beyond the national narratives which continue to dominate the field, in particular through connecting the case of the Armenian Genocide to what has been termed a ‘transnational turn’ in the writing of the history of the First World War

Torner (Grandchildren)

Armenian translation of Torunlar (Ayşe Gül Altınay and Fethiye Çetin, Metis, 2009

The grandchildren: the hidden legacy of 'lost' Armenians in Turkey

The Grandchildren is a collection of intimate, harrowing testimonies by grandchildren and great-grandchildren of Turkey’s "forgotten Armenians"—the orphans adopted and Islamized by Muslims after the Armenian genocide. Through them we learn of the tortuous routes by which they came to terms with the painful stories of their grandparents and their own identity. The postscript offers a historical overview of the silence about Islamized Armenians in most histories of the genocide. When Fethiye Çetin first published her groundbreaking memoir in Turkey, My Grandmother, she spoke of her grandmother’s hidden Armenian identity. The book sparked a conversation among Turks about the fate of the Ottoman Armenians in Anatolia in 1915. This resulted in an explosion of debate on Islamized Armenians and their legacy in contemporary Muslim families. The Grandchildren (translated from Turkish) is a follow-up to My Grandmother, and is an important contribution to understanding survival during atrocity. As witnesses to a dark chapter of history, the grandchildren of these survivors cast new light on the workings of memory in coming to terms with difficult pasts

The space between us: feminist conversations on genocide, survival and gender

This chapter is part of a book project, tentatively titled "Mirroring Lives Across the Armenian Turkish Divide: Feminist Conversations on Genocide and Racism" that is based on semi-structured, in-depth, and highly interactive conversations. We borrow the title of our article from one of the pathbreaking works of feminist scholar Cynthia Cockburn (1998), The Space Between Us, that brings forth the powerful stories of women activists who connect across borders and divides. In this article, organized around the keywords of genocide, survival and gender, we share a small portion of how our conversations tackle the “space between us,” the spaces that have formed us, as well as those we have created together across the Turkish Armenian divide, the US and Turkey, academia and activism, as well as our different positionalities as the grandchildren of the survivors, victims and perpetrators of the Armenian genocide. Bringing the personal and the political as well as the academic in intimate conversations, through critical storytelling (Hannah Arendt, see Disch 1994) and affective solidarity (Hemming 2012), our joint work aims to provide an intersectional feminist intervention into the debates about genocide and racism, as well as their complicated legacies in different contexts