A case of acquired reactive perforating collagenosis with diabetes mellitus and renal failure

Reactive perforating collagenosis is a rare disease of elimination of altered collagen through the epidermis. Its synonym is collagenoma perforans verruciforme. The disease exists especially with diabetes mellitus and chronic renal failure and also with hyperparathyroidism, hypothyroidism, lymphoma, malignancy, neurodermatitis, liver disease, atopic dermatitis, scabies, acquired immune deficiency syndrome, pulmonary fibrosis and herpes zoster infection. In the review of literature, we present a case with acquired reactive perforating collagenosis associated with diabetes mellitus and renal failure

Diffusion tensor imaging can discriminate the primary cell type of intracranial metastases for patients with lung cancer

Purpose: Histopathological differentiation of primary lung cancer is clinically important. We aimed to investigate whether diffusion tensor imaging (DTI) parameters of metastatic brain lesions could predict the histopathological types of the primary lung cancer. Methods: In total, 53 patients with 98 solid metastatic brain lesions of lung cancer were included. Lung tumors were subgrouped as non-small cell carcinoma (NSCLC) (n = 34) and small cell carcinoma (SCLC) (n = 19). Apparent diffusion coefficient (ADC) and Fractional anisotropy (FA) values were calculated from solid enhanced part of the brain metastases. The association between FA and ADC values and histopathological subtype of the primary tumor was investigated. Results: The mean ADC and FA values obtained from the solid part of the brain metastases of SCLC were significantly lower than the NSCLC metastases (P 0.909 × 10-3 mm2/s for mean ADC (Sensitivity = 80.3, Specificity = 83.8, PPV = 89.1, NPV = 72.1) and > 0.139 for FA values (Sensitivity = 80.3, Specificity = 54.1, PPV = 74.2, NPV= 62.5) revealed in differentiating NSCLC from NSCLC. Conclusion: DTI parameters of brain metastasis can discriminate SCLC and NSCLC. ADC and FA values of metastatic brain lesions due to the lung cancer may be an important tool to differentiate histopathological subgroups. DTI may guide clinicians for the management of intracranial metastatic lesions of lung cancer