Survival outcomes of patients with oligometastatic non-small cell lung cancer who were treated with radical therapy: A multicenter analysis

Background/aim: Oligometastatic disease for nonsmall cell lung cancer (NSCLC) patients is generally thought to represent a better prognosis with a quieter biology, limited number of disease sites and long-term disease control. In this study, we aimed to determine the efficacy of radical treatment options for patients with oligometastatic NSCLC. Materials and methods: This retrospective trial included totally 134 patients with oligometastatic NSCLC. The presence of oncodriver mutation, tumor stages and nodal status, the number of metastases and involved metastatic site, treatment of primary tumor and oligometastasis, response rate, overall survival (OS) and progression-free survival (PFS) were evaluated. Results: Of 134 patients 66.4% were defined as adenocarcinoma, 26.1% were squamous cell carcinoma and 7.5% of patients were in other histology. Based on the treatment of primary tumor, in 36 patients (26.9%) curative surgery has undergone, in addition, 19 (14.2%) patients were received chemotherapy, 73 (54.5%) were treated with chemoradiotherapy, while immunotherapy and targeted therapy were used in 1 (0.7%) and 2 (1.4%), respectively. The preferred treatment for oligometastatic lesions were SBRT in 72.4% of patients, surgery in 10.5%, and both SBRT and surgery in 17.1% of patients. At the median follow up of 31.3 months (range: 9.5–48.5), the median PFS and OS times were 17 and 24.4 months, respectively. Moreover, OS-2 after progression was also 7.2 months. Conclusion: Based on our real-life experience, we demonstrated a significant correlation between good response to first treatment and survival in oligometastatic disease, we also understand that local ablative treatment modalities prolong and also delay both OS and PFS in oligometastatic NSCLC patients OS-2

Does Providing Clinical Care for Trauma Patients have a Positive Effect on Physicians’ Perspective on Child Passenger Safety?

Introduction: Motor vehicle crashes are the most common cause of the mortality in the pediatric population. Preventive strategies are the best approach to reduce mortality and morbidity due to motor vehicle crashes. Since parents mostly refer to them for guidance, doctors should have a high level of knowledge and awareness to increase the usage of car safety seats. We thought that providing care for trauma patients could have a positive effect on the physicians’ awareness and knowledge level. Based on this, we aimed to assess the awareness and knowledge of pediatricians and emergency physicians and trauma doctors. Methods: An electronic survey consisting of 23 questions was prepared. Demographic features, awareness and knowledge level of the physicians were assessed on three sections. Five suggestions in the guideline of the American Academy of Pediatrics were used to assess physicians’ knowledge level. The respondents were grouped as those providing clinical care for trauma patients and those do not. Results: The questionnaires were sent to 641 physicians and 323 who completed the questionnaire were included in the study. One hundred and fourteen (35.3%) of the respondents were providing clinical care for trauma patients. One hundred ninety (59.2%) respondents had children. Majority of the physicians had a satisfactory level of knowledge about car safety seat (CSS). The number of respondents reported having adequate self-awareness was found statistically significantly higher in the groups of doctors who have children and provide clinical care for trauma patients (p0.05). Interestingly, the knowledge level in physicians who had children was statistically significantly lower than in those with no children (p<0.01). Conclusion: Our survey revealed that physicians who provide clinical care for trauma patients think they have a high level of knowledge about CSS. Unfortunately, their knowledge level was low as other physicians in the study group

Partial-breast irradiation - Current situation with evidence

WOS: 000395502400001PubMed ID: 28331760The implementation of breast-conserving surgery in the management of early breast cancer is one of the most important successes of the modern treatments in the field. Numerous randomized clinical trials initiated more than 30 years ago have reported 20-year durable results documenting that survival is equivalent to mastectomy when the breast is conserved by removal of the index cancer with wide excision followed by whole-breast radiotherapy

Use of MRI fusion for CT based intracranial stereotactic radiosurgery

11th Congress of the European-Association-of-Neuro-Oncology -- OCT 09-12, 2014 -- Turin, ITALYWOS: 000344235700014The aim of this study is to evaluate the reliability of MRI fusion when determining intracranial target volume when performing CT based intracranial stereotactic radiosurgery. Patients treated with CT based intracranial stereotactic radiosurgery with various diagnosis are included in the study. All patients were immobilized using stereotactic thermoplastic masks prior to simulation. The planning CT was obtained both with and without iv contrast with 1mm slice thickness. The images obtained were then fused with 3D, T1 weighted MR images with contrast by two different platforms (Eclipse 10.0, Velocity 3.0 rigid and Velocity 3.0 deformable).European Association of Neuro-Oncolog

Boost volume assessment in breast cancer: Preop tumor volume vs clips used in oncoplastic surgery

WOS: 000463117902107The aim of this study was to compare the volumes obtained with surgical clips during breast conserving surgery of breast cancer patients with volume determined using FDG positive tumor volumes outlined in pre -operative PET-CT imaging and find out the deviations that arise

Feasibility investigation of prone position robotic radiosurgery treatment for dorsal metastasis

WOS: 000467786304100The combination of Adaptive Radiotherapy (ART) and VMAT allows to create more conformal plans for patients with bladder cancer without risk of missing target during changes of bladder volume and shape. Relative position of small bowel is influenced by the volume of treated bladder. Recent reviews demonstrated the advantages of using ART in bowel sparing during bladder irradiation. The aim of this study was to assess feasibility of simultaneous sparing of bone marrow, small bowel and rectum using combination of ART and VMAT